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Featured Upstate South Carolina Historic Hotels
The Westin Poinsett Greenville
120 South Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
Holiday Inn Express & Suites Clemson, an IHG Hotel
1381 Tiger Blvd, Clemson, SC
Fully refundable
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
The Bleckley Inn
151 E Church St, Anderson, SC
Stay at this 3.5-star business-friendly hotel in Anderson. Enjoy free parking, a rooftop terrace, and a fitness center. Popular attractions Church Street Heritage ...
Hampton Inn & Suites Greenville-Downtown-RiverPlace
171 Riverplace, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the clean ...
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
Holiday Inn Express & Suites Greenville - Downtown, an IHG Hotel
407 North Main Street, Greenville, SC
Fully refundable
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
Pettigru Place Bed & Breakfast
302 Pettigru Street, Greenville, SC
Stay at this 3.5-star B&B in Greenville. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
Aloft Greenville Downtown
5 North Laurens Street, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
Courtyard by Marriott Greenville Downtown
50 W Broad St, Greenville, SC
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, 3 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the clean ...
Swamp Rabbit Inn
1 Logan Street, Greenville, SC
Fully refundable
Stay at this 3-star business-friendly B&B in Greenville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fluor Field at the West End and ...
Quality Inn & Suites Greenville near downtown
10 Mills Ave, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Upstate South Carolina
- Hotels with Free Parking in Upstate South Carolina
- Family Hotels in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Apartment Hotel in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Resorts & Hotels with Spas in Upstate South Carolina
Upstate South Carolina Neighborhoods
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near Haywood Mall
- Hotels near BMW Performance Center
- Hotels near Bon Secours Wellness Arena
- Hotels near Falls Park on the Reedy
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near The Peace Center
- Hotels near Lake Jocassee
- Hotels near Greenville Convention Center
- Hotels near Fred W. Symmes Chapel
- Hotels near Wofford College
- Hotels near Bob Jones University
- Hotels near Table Rock State Park
- Hotels near Devils Fork State Park
- Hotels near WestGate Mall
- Hotels near Anderson University
- Hotels near Fluor Field at the West End
- Hotels near Memorial Stadium
- Hotels near Spartanburg Memorial Auditorium
- Hotels near University of South Carolina Upstate
Cities near Upstate South Carolina
- Highlands Hotels (55.49 mi)
- Greenville Hotels (8.73 mi)
- Franklin Hotels (68.54 mi)
- Hendersonville Hotels (39.13 mi)
- Clemson Hotels (32.31 mi)
- Rock Hill Hotels (71.73 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Spartanburg Hotels (23.13 mi)
- Black Mountain Hotels (58.45 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Seneca Hotels (38.76 mi)
- Brevard Hotels (40.98 mi)
- Anderson Hotels (28.12 mi)
- Lake Lure Hotels (45.56 mi)
- Cashiers Hotels (52.06 mi)
- Ninety Six Hotels (43.69 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Highlands
- Car rentals in Greenville
- Car rentals in Franklin
- Car rentals in Hendersonville
- Car rentals in Clemson
- Car rentals in Rock Hill
- Car rentals in North Carolina Mountains
- Car rentals in Spartanburg
- Car rentals in Black Mountain
- Car rentals in Blue Ridge Mountains
- Car rentals in Seneca
- Car rentals in Brevard
- Car rentals in Anderson
- Car rentals in Lake Lure
- Car rentals in Cashiers
- Car rentals in Ninety Six
Top Historic Hotel Destinations
- Pasadena Historic Hotel
- Downtown Minneapolis Historic Hotel
- Downtown Boise Historic Hotel
- Brooklyn Historic Hotel
- Downtown Seattle Historic Hotel
- Downtown St Louis Historic Hotel
- Detroit Historic Hotel
- Downtown Nashville Historic Hotel
- Minnesota Historic Hotel
- Downtown Dallas Historic Hotel
- Downtown Edmonton Historic Hotel
- Oklahoma Historic Hotel
- Downtown Omaha Historic Hotel
- Downtown Kansas City Historic Hotel
- Downtown Salt Lake City Historic Hotel
- Raleigh Historic Hotel
- Downtown Reno Historic Hotel
- Baltimore Historic Hotel
- Tampa Historic Hotel
- Atlanta Historic Hotel
Top Booked Hotels in Upstate South Carolina
- Hyatt Place Greenville/Haywood
- Hyatt Place Greenville/Downtown
- Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
- Best Western Plus Clemson Hotel & Conference Center
- Best Western Plus Greenville I-385 Inn & Suites
- Hilton Greenville
- Courtyard by Marriott Greenville Haywood Mall
- La Quinta Inn & Suites by Wyndham Greenville Haywood
- Hyatt Regency Greenville
- Aloft Greenville Downtown