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Featured Upstate South Carolina Resorts & Hotels with Spas
Drury Inn & Suites Greenville
10 Carolina Point Pkwy, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG
275 Frontage Road, Duncan, SC
Fully refundable
Book a stay at this business-friendly hotel in Duncan. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Suites Greenville South
10 Kalyns Way, Piedmont, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Piedmont. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Budget Inn
224 Bruce Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this motel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Bon Secours Wellness Arena and Haywood Mall are located ...
Courtyard Greenville-Spartanburg by Marriott
115 The Pkwy, Greer, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greer. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Courtyard Marriott Clemson
201 Canoy Ln, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Clemson Area African American ...
Days Inn by Wyndham Greenville South/Mauldin
360 W Butler Rd, Mauldin, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Mauldin. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Fairfield Inn by Marriott Greenville-Spartanburg Airport
48 Fisherman Ln, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff in our ...
Greenville Marriott
One Parkway E, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn Easley
8 Southern Center Ct, Easley, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Easley. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Upstate South Carolina
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- Hotel Wedding Venues in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Apartment Hotel in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
Upstate South Carolina Neighborhoods
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near BMW Performance Center
- Hotels near Haywood Mall
- Hotels near Falls Park on the Reedy
- Hotels near Lake Jocassee
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Greenville Convention Center
- Hotels near Bon Secours Wellness Arena
- Hotels near Bob Jones University
- Hotels near The Peace Center
- Hotels near Devils Fork State Park
- Hotels near Wofford College
- Hotels near Memorial Stadium
- Hotels near Anderson University
- Hotels near Fred W. Symmes Chapel
- Hotels near WestGate Mall
- Hotels near Fluor Field at the West End
- Hotels near Table Rock State Park
- Hotels near Frankie's Fun Park
- Hotels near University of South Carolina Upstate
Cities near Upstate South Carolina
- Greenville Hotels (8.73 mi)
- Highlands Hotels (55.49 mi)
- Rock Hill Hotels (71.73 mi)
- Clemson Hotels (32.31 mi)
- Hendersonville Hotels (39.13 mi)
- Franklin Hotels (68.54 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Spartanburg Hotels (23.13 mi)
- Anderson Hotels (28.12 mi)
- Seneca Hotels (38.76 mi)
- Brevard Hotels (40.98 mi)
- Lake Lure Hotels (45.56 mi)
- Black Mountain Hotels (58.45 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Cashiers Hotels (52.06 mi)
- Gastonia Hotels (70.54 mi)
- Clayton Hotels (64.05 mi)
- Greer Hotels (11.86 mi)
- Shelby Hotels (55.26 mi)
- Central Hotels (28.72 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Greenville
- Car rentals in Highlands
- Car rentals in Rock Hill
- Car rentals in Clemson
- Car rentals in Hendersonville
- Car rentals in Franklin
- Car rentals in North Carolina Mountains
- Car rentals in Spartanburg
- Car rentals in Anderson
- Car rentals in Seneca
- Car rentals in Brevard
- Car rentals in Lake Lure
- Car rentals in Black Mountain
- Car rentals in Blue Ridge Mountains
- Car rentals in Cashiers
- Car rentals in Gastonia
Top Spa Resort Destinations
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