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Featured Upstate South Carolina Resorts & Hotels with Spas
Drury Inn & Suites Greenville
10 Carolina Point Pkwy, Greenville, SC
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
Holiday Inn Express & Suites Greenville-Spartanburg (Duncan), an IHG Hotel
275 Frontage Road, Duncan, SC
Fully refundable
Book a stay at this business-friendly hotel in Duncan. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Suites Greenville South
10 Kalyns Way, Piedmont, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Piedmont. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Budget Inn
224 Bruce Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this motel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Falls Park on the Reedy and Bon Secours Wellness Arena ...
Courtyard Greenville-Spartanburg by Marriott
115 The Pkwy, Greer, SC
Stay at this 3-star business-friendly hotel in Greer. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Courtyard Marriott Clemson
201 Canoy Ln, Clemson, SC
Stay at this 3-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Clemson Area African American ...
Days Inn by Wyndham Greenville South/Mauldin
360 W Butler Rd, Mauldin, SC
Book a stay at this business-friendly hotel in Mauldin. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Fairfield Inn by Marriott Greenville-Spartanburg Airport
48 Fisherman Ln, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff in our ...
Greenville Marriott
One Parkway E, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn Easley
8 Southern Center Ct, Easley, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Easley. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Upstate South Carolina
- Hotels with Free Parking in Upstate South Carolina
- Family Hotels in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Apartment Hotel in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
Upstate South Carolina Neighborhoods
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near Haywood Mall
- Hotels near Falls Park on the Reedy
- Hotels near Bon Secours Wellness Arena
- Hotels near The Peace Center
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Greenville Convention Center
- Hotels near Lake Jocassee
- Hotels near BMW Performance Center
- Hotels near Fred W. Symmes Chapel
- Hotels near Memorial Stadium
- Hotels near Bob Jones University
- Hotels near Spartanburg Memorial Auditorium
- Hotels near Table Rock State Park
- Hotels near Anderson University
- Hotels near WestGate Mall
- Hotels near T. Ed Garrison Arena
- Hotels near Wofford College
- Hotels near University of South Carolina Upstate
- Hotels near Converse College
Cities near Upstate South Carolina
- Greenville Hotels (8.73 mi)
- Highlands Hotels (55.49 mi)
- Franklin Hotels (68.54 mi)
- Hendersonville Hotels (39.13 mi)
- Clemson Hotels (32.31 mi)
- Rock Hill Hotels (71.73 mi)
- Spartanburg Hotels (23.13 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Anderson Hotels (28.12 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Seneca Hotels (38.76 mi)
- Black Mountain Hotels (58.45 mi)
- Brevard Hotels (40.98 mi)
- Gastonia Hotels (70.54 mi)
- Clayton Hotels (64.05 mi)
- Cashiers Hotels (52.06 mi)
- Greer Hotels (11.86 mi)
- Kings Mountain Hotels (62.26 mi)
- Lake Lure Hotels (45.56 mi)
- Shelby Hotels (55.26 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Greenville
- Car rentals in Highlands
- Car rentals in Franklin
- Car rentals in Hendersonville
- Car rentals in Clemson
- Car rentals in Rock Hill
- Car rentals in Spartanburg
- Car rentals in Blue Ridge Mountains
- Car rentals in Anderson
- Car rentals in North Carolina Mountains
- Car rentals in Seneca
- Car rentals in Black Mountain
- Car rentals in Brevard
- Car rentals in Gastonia
- Car rentals in Clayton
- Car rentals in Cashiers
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels
Top Booked Hotels in Upstate South Carolina
- Hilton Greenville
- Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
- Best Western Plus Greenville I-385 Inn & Suites
- Embassy Suites Greenville Golf Resort & Conference Center
- La Quinta Inn & Suites by Wyndham Greenville Haywood
- Hyatt Regency Greenville
- Midtown Suites-Greenville
- Days Inn by Wyndham Greenville
- Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd