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Featured Upstate South Carolina Resorts & Hotels with Spas
Days Inn by Wyndham Greenville South/Mauldin
360 W Butler Rd, Mauldin, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Mauldin. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Drury Inn & Suites Greenville
10 Carolina Point Pkwy, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
Holiday Inn Express & Suites Greenville-Spartanburg (Duncan), an IHG Hotel
275 Frontage Road, Startex, SC
Fully refundable
Book a stay at this business-friendly hotel in Startex. Enjoy free breakfast, free WiFi, and free parking. Popular attractions River Falls Golf Course and Shipwreck ...
Comfort Suites Greenville South
10 Kalyns Way, Piedmont, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Piedmont. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Budget Inn
224 Bruce Rd, Greenville, SC
Book a stay at this family-friendly motel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Falls Park on the Reedy and ...
Courtyard Greenville-Spartanburg by Marriott
115 The Pkwy, Greer, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greer. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Haywood Mall and Topgolf ...
Courtyard Marriott Clemson
201 Canoy Ln, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the clean rooms in our reviews. ...
Fairfield Inn by Marriott Greenville-Spartanburg Airport
48 Fisherman Ln, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Greenville Marriott
One Parkway E, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hampton Inn Easley
8 Southern Center Ct, Easley, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Easley. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
Upstate South Carolina Neighborhoods
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near Lake Jocassee
- Hotels near Falls Park on the Reedy
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Bon Secours Wellness Arena
- Hotels near Haywood Mall
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Wofford College
- Hotels near Devils Fork State Park
- Hotels near Anderson University
- Hotels near BMW Performance Center
- Hotels near Bob Jones University
- Hotels near Fluor Field at the West End
- Hotels near Fred W. Symmes Chapel
- Hotels near Memorial Stadium
- Hotels near Heritage Park
- Hotels near Table Rock State Park
- Hotels near WestGate Mall
- Hotels near University of South Carolina Upstate
Cities near Upstate South Carolina
- Greenville Hotels (8.73 mi)
- Lake Lure Hotels (45.56 mi)
- Highlands Hotels (55.49 mi)
- Hendersonville Hotels (39.13 mi)
- Black Mountain Hotels (58.45 mi)
- Franklin Hotels (68.54 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Rock Hill Hotels (71.73 mi)
- Brevard Hotels (40.98 mi)
- Anderson Hotels (28.12 mi)
- Spartanburg Hotels (23.13 mi)
- Cashiers Hotels (52.06 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Clemson Hotels (32.31 mi)
- Seneca Hotels (38.76 mi)
- Tuckasegee Hotels (58.84 mi)
- Clayton Hotels (64.05 mi)
- Gastonia Hotels (70.54 mi)
- Arden Hotels (49.77 mi)
- Flat Rock Hotels (35.68 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Greenville
- Car rentals in Lake Lure
- Car rentals in Highlands
- Car rentals in Hendersonville
- Car rentals in Black Mountain
- Car rentals in Franklin
- Car rentals in North Carolina Mountains
- Car rentals in Rock Hill
- Car rentals in Brevard
- Car rentals in Anderson
- Car rentals in Spartanburg
- Car rentals in Cashiers
- Car rentals in Blue Ridge Mountains
- Car rentals in Clemson
- Car rentals in Seneca
- Car rentals in Tuckasegee
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels