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Hotels in Sikeston

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Choose from 267 Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
"Best hotel ever loved it"

Reviewed on Jun 7, 2025

Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
"Curtains needed replaced. TV did not work at all (Dish Network) the entire night we were there. Well, the TV worked, but Dish did not, so we were not able to watch anything. Breakfast was just ok."

Reviewed on Jun 14, 2025

Best Western Plus Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"We were there to get a good nights sleep and we did."

Reviewed on Jun 2, 2025

Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
"Relaxing"

Reviewed on Jun 11, 2025

Pear Tree Inn Sikeston
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 27 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (354 reviews)
"R"

Reviewed on Jun 2, 2025

Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 26 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (408 reviews)
"We pulled in late one evening. The ladies at the front desk were extremely nice and so helpful."

Reviewed on May 26, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
7/10 Good! (93 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2 out of 5
2609 E Malone Ave, Sikeston, MO
  • 6 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
6.6/10 (537 reviews)
"The staff here is always so nice."

Reviewed on Jun 8, 2025

Super 8 by Wyndham Sikeston/Miner Area
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (261 reviews)
"Clean"

Reviewed on Jun 7, 2025

Comfort Inn & Suites Sikeston I-55
Fairfield by Marriott Inn & Suites Sikeston
Fairfield by Marriott Inn & Suites Sikeston
2.5 out of 5
1239 Commerce Drive, Sikeston, MO
  • 29 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
9.4/10 Exceptional! (3 reviews)
"New hotel. Very nice. Everything was clean, and breakfast was great!"

Reviewed on Jun 2, 2025

Fairfield by Marriott Inn & Suites Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 1 hour drive from Sikeston Depot Museum
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
Excellent seevice
"The staff was amazing! Always smiling!!"

Reviewed on Jun 16, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
  • 1 hour drive from Sikeston Depot Museum
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (296 reviews)
"Clean, average hotel. Bring earplugs, lots of outdoor noise (traffic, river dredging noise etc) We would not stay again due to the noise."

Reviewed on Jun 14, 2025

The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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