Hotels Near
Mission District

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Featured Mission District Hotels

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (5,245 reviews)
Perfect location. Clean. Beautiful.

Reviewed on Feb 7, 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.8/10 Excellent! (7,288 reviews)
My room was spotless, the bed sooo comfy and the room was so quiet, I slept like a baby. The entire hotel staff was attentive, professional and eager to make guests feel comfortable. The breakfast buffet was top notch! It is rare to see this variety of breakfast items. There surely was something ...

Reviewed on Feb 4, 2026

Hotel Riu Plaza Fisherman's Wharf
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

3 out of 5
701 3rd St San Francisco CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (1,981 reviews)
Rumor's clean and comfortable. This part of SF is desamp without much homelessness

Reviewed on Feb 5, 2026

Hyatt Place San Francisco Downtown
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (2,375 reviews)
Room was clean and staff was nice! They answered all questions I had and were really helpful overall!

Reviewed on Feb 6, 2026

Hilton San Francisco Financial District
Comfort Inn by the Bay

Comfort Inn by the Bay

2.5 out of 5
2775 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the ...
8.2/10 Very Good! (1,304 reviews)
Excellent Guest Service

Reviewed on Feb 4, 2026

Comfort Inn by the Bay
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.8/10 Excellent! (2,948 reviews)
Large spot on floor, wall dirty or scuffed up, very far from elevator for being an accessible room.

Reviewed on Feb 6, 2026

Club Quarters Hotel in San Francisco
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (2,062 reviews)
Clean

Reviewed on Jan 28, 2026

Hyatt Regency San Francisco
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

3 out of 5
1550 Bayshore Hwy Burlingame CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (4,817 reviews)
Staff, room, bonus add-ons, excellent breakfast, lovely setting by the bay for morning wakeup coffee outside.

Reviewed on Feb 4, 2026

Bay Landing San Francisco Airport Hotel
YOTEL San Francisco

YOTEL San Francisco

3 out of 5
1095 Market St San Francisco CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,005 reviews)
Clean, modern, easy check in/out, affordable for a good location

Reviewed on Feb 5, 2026

YOTEL San Francisco
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.8/10 Excellent! (2,844 reviews)
Location and reasonable rates

Reviewed on Feb 1, 2026

Handlery Union Square Hotel
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (4,256 reviews)
Easy check in, clean rooms, helpful staff, great location with bay views, park access, and good on-site restaurant service. I enjoyed my stay.

Reviewed on Feb 6, 2026

DoubleTree by Hilton Hotel Berkeley Marina
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

4 out of 5
1300 Columbus Avenue San Francisco CA
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (3,830 reviews)
Location was perfect, hotel checking was a breeze, staff was very helpful. Will stay here again!

Reviewed on Feb 1, 2026

Hotel Caza Fisherman's Wharf
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Mission District

San Francisco is a city that has a lot going on, but you have your sights set on Mission District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Mission District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Mission District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Francisco so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Mission District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Mission District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Mission District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Mission District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $121
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Mission District hotel you want, book it, and never look back. Because your great escape is ahead of you.