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Hotels in South San Francisco

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Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2 out of 5
326 S Airport Blvd South San Francisco CA
  • 3 min walk from South San Francisco Convention Center
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
6/10 (3,471 reviews)
Overall a poor accommodation, would not stay there again. They don’t answer the phone!!!! I tried multiple times. 3 different phone numbers. We requested early check-in months earlier because our over-night flight arrived 8:10 am. Tried phoning to confirm early check-in before we left airport but ...

Reviewed on Apr 15, 2026

Travelodge by Wyndham San Francisco Airport North
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

3 out of 5
380 S Airport Boulevard South San Francisco CA
  • 6 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,765 reviews)
There is no shuttle during the day . The hotel is 3 miles from airport and you will be charged $30 minimum by uber. Don’t get there early, 30 minutes before check in and if I did not wait it was a $34 surcharge. Never again…

Reviewed on Apr 14, 2026

Best Western Plus Grosvenor Airport Hotel
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

4 out of 5
275 S Airport Blvd South San Francisco CA
  • 2 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (2,234 reviews)
G

Reviewed on Apr 15, 2026

DoubleTree by Hilton San Francisco South Airport Blvd
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 out of 5
250 Gateway Blvd South San Francisco CA
  • 12 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise ...
8.6/10 Excellent! (1,356 reviews)
Am so glad l chose Embassy suit I really enjoyed it very much

Reviewed on Apr 15, 2026

Embassy Suites by Hilton San Francisco Airport Oyster Point
Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront

3 out of 5
1300 Veterans Blvd South San Francisco CA
  • 29 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.8/10 Excellent! (2,037 reviews)
It was a very nice stay.

Reviewed on Apr 15, 2026

Sonesta Select San Francisco Airport Oyster Point Waterfront
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
  • 7 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
8.2/10 Very Good! (1,988 reviews)
They are a bunch of thieves I called and let them know I forgot my granddaughter favorite blanket on the bed, both front desk associates answers were about the same “if We find it we call you. It’s been 2 days now and no call received.

Reviewed on Apr 14, 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

3 out of 5
1350 Veterans Boulevard South San Francisco CA
  • 4 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,063 reviews)
I noted several health violations at this property. Asked to see management several times with no luck.

Reviewed on Apr 14, 2026

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (5,561 reviews)
Lovely view, friendly staff, comfortable bed and pillows

Reviewed on Apr 15, 2026

Holiday Inn Golden Gateway by IHG
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
  • 23 min drive from South San Francisco Convention Center
Book a stay at this family-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.8/10 Excellent! (3,016 reviews)
Pool was clean, Staff is polite and helpful and the rooms are comfortable and clean.

Reviewed on Apr 15, 2026

Handlery Union Square Hotel
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
  • 27 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,381 reviews)
We basically just slept at the hotel one night, ate breakfast the next morning, and caught our flight home. We had no complaints! Rooms are spacious and comfortable and the breakfast was impressive. Would stay here again!

Reviewed on Apr 15, 2026

Hotel Riu Plaza Fisherman's Wharf
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
  • 25 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,060 reviews)
Room was immaculate and quiet, and everything worked as expected.

Reviewed on Apr 14, 2026

Club Quarters Hotel in San Francisco
YOTEL San Francisco

YOTEL San Francisco

3 out of 5
1095 Market St San Francisco CA
  • 22 min drive from South San Francisco Convention Center
Stay at this hotel in San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.2/10 Very Good! (1,008 reviews)
Great location if you need to be downtown. We were there for two nights for a show at Bill Graham and it was great walking to everywhere. Only thing I would have changed is that the “view” that I paid extra for was not viewable from anywhere in the room except the bathroom. Plus the room was quite ...

Reviewed on Apr 15, 2026

YOTEL San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 5,075 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $72. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $72.

How many hotels are there in South San Francisco?

With over 5,075 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $72.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.