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Hotels in South San Francisco

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Last Minute Hot Rate® Hotel Deals in South San Francisco

We Hide Hotel Names So You Can Find 4-Star Hotels At 2-Star Prices. Choose the Location, Star Rating & Amenities. Let Hotwire Find You the Best Deal. Book Today!

Choose from 5242 South San Francisco Hotel Deals

Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2 out of 5
326 S Airport Blvd, South San Francisco, CA
  • 4 min walk from South San Francisco Convention Center
The price is $59 per night from May 5 to May 6
$59
per night
May 5 - May 6
Stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, onsite parking, and a 24-hour front desk. Our guests praise the clean rooms in ...
6/10 (1,885 reviews)
"Absolutely great value"

Reviewed on Apr 29, 2024

Travelodge by Wyndham San Francisco Airport North
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
The price is $127 per night from May 19 to May 20
$127
per night
May 19 - May 20
Stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.2/10 Very Good! (1,551 reviews)
"We only stayed a few hours between flights. Shuttle worked out well. Very nice hotel and convenient to airport"

Reviewed on Apr 27, 2024

DoubleTree by Hilton San Francisco South Airport Blvd
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
2.5 out of 5
20 Airport Blvd, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
The price is $93 per night from May 11 to May 12
$93
per night
May 11 - May 12
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
7.8/10 Good! (1,890 reviews)
"Needed a place to park a 2 car trailer and it was just what I needed . Close to the airport for friend to meet us at Hotel."

Reviewed on Apr 29, 2024

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Home2 Suites by Hilton San Francisco Airport North
Home2 Suites by Hilton San Francisco Airport North
3 out of 5
550 Gateway Blvd, South San Francisco, CA
  • 16 min walk from South San Francisco Convention Center
The price is $108 per night from May 12 to May 13
$108
per night
May 12 - May 13
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (871 reviews)
"I liked that the rooms had 2 beds with a pull out couch."

Reviewed on Apr 26, 2024

Home2 Suites by Hilton San Francisco Airport North
Holiday Inn Golden Gateway, an IHG Hotel
Holiday Inn Golden Gateway, an IHG Hotel
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $130 per night from May 27 to May 28
$130
per night
May 27 - May 28
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and onsite parking. Our guests praise the pool and the helpful ...
8.6/10 Excellent! (2,485 reviews)
"Perfect location as its steps from the trolly line. Amazing views and friendly staff. Would stay again for sure."

Reviewed on Apr 30, 2024

Holiday Inn Golden Gateway, an IHG Hotel
Hyatt Regency San Francisco
Hyatt Regency San Francisco
4 out of 5
5 Embarcadero Center, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
The price is $179 per night from May 3 to May 4
$179
per night
May 3 - May 4
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and room service. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,857 reviews)
"Beautiful facility with nice staff, beautiful area clean rooms, nice stay!"

Reviewed on Apr 30, 2024

Hyatt Regency San Francisco
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $148 per night from May 27 to May 28
$148
per night
May 27 - May 28
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.6/10 Excellent! (6,153 reviews)
"Older hotel, but reasonably well maintained & comfortable. Check in process took *way* too long. “Resort Fees” of $40/day are added (& have recently increased) to justify things that are normally included by default - such as room cleaning… Breakfast was very decent, but eating area placed tables ..."

Reviewed on Apr 29, 2024

Hotel Riu Plaza Fisherman's Wharf
Club Quarters Hotel in San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
424 Clay St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
The price is $120 per night from Jun 1 to Jun 2
$120
per night
Jun 1 - Jun 2
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and room service. Our guests praise the restaurant and the helpful ...
8.6/10 Excellent! (1,607 reviews)
"For the price, you get what you paid for. But for minor inconveniences like a bathroom bidet or free breakfast included from payment, it may be what you'd want for your hotel stay here. Still a good stay overall."

Reviewed on Apr 28, 2024

Club Quarters Hotel in San Francisco
King George Hotel
King George Hotel
3 out of 5
334 Mason Street, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $85 per night from May 30 to May 31
$85
per night
May 30 - May 31
Stay at this hotel in San Francisco. Enjoy WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our ...
8.4/10 Very Good! (1,491 reviews)
Heart of the Loin
"Excellent location for food, shows, and the tour bus."

Reviewed on Apr 29, 2024

King George Hotel
The Marker San Francisco
The Marker San Francisco
4 out of 5
501 Geary St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $110 per night from May 10 to May 11
$110
per night
May 10 - May 11
Stay at this boutique hotel in San Francisco. Enjoy breakfast, a 24-hour fitness center, and valet parking. Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (1,000 reviews)
"Enjoyed our stay. The large deep tub was amazing."

Reviewed on Apr 29, 2024

The Marker San Francisco
Hotel Caza Fisherman's Wharf
Hotel Caza Fisherman's Wharf
4 out of 5
1300 Columbus Avenue, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $169 per night from May 2 to May 3
$169
per night
May 2 - May 3
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (3,547 reviews)
"It was good, we got early and they let us check in early. the only thing is that our view was to an alley that was ugly and dirty. The trash container was there. But everything else was good."

Reviewed on May 1, 2024

Hotel Caza Fisherman's Wharf
Chancellor Hotel on Union Square
Chancellor Hotel on Union Square
3.5 out of 5
433 Powell St, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $134 per night from May 10 to May 11
$134
per night
May 10 - May 11
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and a business center. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (1,805 reviews)
"Clean, walkable, and quaint. Loved it and would stay again in the future!"

Reviewed on May 1, 2024

Chancellor Hotel on Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in South San Francisco

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your South San Francisco hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 5,242 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $59. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $59.

How many hotels are there in South San Francisco?

With over 5,242 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to South San Francisco now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to South San Francisco right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.