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Hotels in South San Francisco

Choose from 5046 South San Francisco Hotel Deals

Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta Select San Francisco Airport Oyster Point Waterfront
3 out of 5
1300 Veterans Blvd, South San Francisco, CA
  • 29 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.4/10 Very Good! (1,540 reviews)
"Everything was great."

Reviewed on May 27, 2025

Sonesta Select San Francisco Airport Oyster Point Waterfront
Best Western Plus Grosvenor Airport Hotel
Best Western Plus Grosvenor Airport Hotel
3 out of 5
380 S Airport Boulevard, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
8.2/10 Very Good! (1,480 reviews)
"Breakfast food is below average. No shuttle bus after midnight"

Reviewed on May 23, 2025

Best Western Plus Grosvenor Airport Hotel
Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2 out of 5
326 S Airport Blvd, South San Francisco, CA
  • 4 min walk from South San Francisco Convention Center
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
5.8/10 (2,349 reviews)
"Quick service"

Reviewed on May 21, 2025

Travelodge by Wyndham San Francisco Airport North
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (1,678 reviews)
"Staff member who helped me check in, was very helpful and understanding when I requested a specific room. Due to my grandson's autism. Very thankful"

Reviewed on May 26, 2025

DoubleTree by Hilton San Francisco South Airport Blvd
Holiday Inn Golden Gateway by IHG
Holiday Inn Golden Gateway by IHG
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (4,005 reviews)
"Well designed. Very organized. Friendly staff."

Reviewed on May 27, 2025

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (6,443 reviews)
"the location of the hotel is perfect, close to everything, very safe, we made this trip as a family and we loved it, we would definitely stay there again."

Reviewed on May 27, 2025

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel
Handlery Union Square Hotel
3.5 out of 5
351 Geary St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.6/10 Excellent! (2,413 reviews)
Good location!
"I booked the intermediate room with a queen-size bed, but our room was too small and wasn't very clean. Luckily, the attendant at the front desk was very kind and efficient and changed our room for free. I had a service dog in my reservation, and I have the impression that the hotels always give ..."

Reviewed on May 27, 2025

Handlery Union Square Hotel
Club Quarters Hotel in San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
424 Clay St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.8/10 Excellent! (2,334 reviews)
"It was easy to get to. It was clean nice size room. Bed is comfortable. Liked that they don’t charge a pet fee. You have to park on a parking lot nearby I paid $37 for a day. You could walk to china town from there. The only things I didn’t like it had some carpet stains, the wall was a bit cracked ..."

Reviewed on May 27, 2025

Club Quarters Hotel in San Francisco
Hotel Julian
Hotel Julian
3 out of 5
940 Sutter Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Stay at this 3-star hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Popular attractions Lombard Street and Pier 39 are ...
8.6/10 Excellent! (237 reviews)
Loved it
"Perfect stay, room was clean, quiet, spacious. I was upgraded. Appreciated the bar downstairs and ease. Highly recommend hotel"

Reviewed on May 21, 2025

Hotel Julian
Chancellor Hotel on Union Square
Chancellor Hotel on Union Square
3.5 out of 5
433 Powell St, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Stay at this 3.5-star hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (2,725 reviews)
"Great! Thanks."

Reviewed on May 27, 2025

Chancellor Hotel on Union Square
Hotel Caza Fisherman's Wharf
Hotel Caza Fisherman's Wharf
4 out of 5
1300 Columbus Avenue, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (3,583 reviews)
"Great Spot near so much; Fisherman's Wharf, Trolley Car's, Bus Tour's, Pier 39, Pier 33. Was there 5 days; didn't have to rent car; just did Uber to and from airport, otherwise didn't need a vehicle. Wish Hotel Caza offered complimentary coffee all night long. Evenings are chilly and would of been ..."

Reviewed on May 27, 2025

Hotel Caza Fisherman's Wharf
Hotel Nikko San Francisco
Hotel Nikko San Francisco
4.5 out of 5
222 Mason St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
Stay at this 4.5-star luxury hotel in San Francisco. Enjoy free WiFi, a nightclub, and a rooftop terrace. Our guests praise the breakfast and the pool in our ...
9.2/10 Wonderful! (2,375 reviews)
Awesome
"Super Hteat Experience, definitely coming back"

Reviewed on May 26, 2025

Hotel Nikko San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 5,046 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $76. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $76.

How many hotels are there in South San Francisco?

With over 5,046 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $76.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.