Search for Cheap Deals on
Hotels in South San Francisco

Choose from 4981 South San Francisco Hotel Deals

Best Western Plus Grosvenor Airport Hotel
Best Western Plus Grosvenor Airport Hotel
3 out of 5
380 S Airport Boulevard, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
8.2/10 Very Good! (1,480 reviews)
"Convince location, close to airport. Old, small room. Great breakfast. Old , small room."

Reviewed on Jul 7, 2025

Best Western Plus Grosvenor Airport Hotel
Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta Select San Francisco Airport Oyster Point Waterfront
3 out of 5
1300 Veterans Blvd, South San Francisco, CA
  • 29 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.4/10 Very Good! (1,574 reviews)
"Very clean and friendly, convenient location for Oyster Point offices"

Reviewed on Jul 9, 2025

Sonesta Select San Francisco Airport Oyster Point Waterfront
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (1,724 reviews)
"Great stay!"

Reviewed on Jul 6, 2025

DoubleTree by Hilton San Francisco South Airport Blvd
Holiday Inn Golden Gateway by IHG
Holiday Inn Golden Gateway by IHG
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (4,246 reviews)
"Everything Was Great. Thank you very much. I hope coming very soon so I can enjoy the aria."

Reviewed on Jul 7, 2025

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (6,542 reviews)
"Had one of the best hotel staycations ever! The breakfast buffet was super hearty and delicious. Stayed with friends over the weekend, but I’m already planning to come back with family next time. The location’s great too—just a short walk to all the tourist spots, so totally worth the price."

Reviewed on Jul 8, 2025

Hotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco
Hyatt Regency San Francisco
4 out of 5
5 Embarcadero Center, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
Stay at this 4-star eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,736 reviews)
"My only criticism is that the shower didn't have enough water pressure which made it difficult for me to get the shampoo out of my hair. Other than that, this property is a win!"

Reviewed on Jul 7, 2025

Hyatt Regency San Francisco
InterContinental Mark Hopkins by IHG
InterContinental Mark Hopkins by IHG
4 out of 5
999 California Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Stay at this 4-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,028 reviews)
"Easy-peasy check-in, great front-of-the-house staff, start to finish"

Reviewed on Jul 8, 2025

InterContinental Mark Hopkins by IHG
Crowne Plaza San Francisco Airport by IHG
Crowne Plaza San Francisco Airport by IHG
3.5 out of 5
1177 Airport Blvd, Burlingame, CA
  • 12 min drive from South San Francisco Convention Center
Stay at this 3.5-star business-friendly hotel in Burlingame. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,872 reviews)
"Overall the property is safe, quiet, and has friendly staff. The bar/restaurant, while not well-attended, is great for having food and a beverage. The hotel is old and needs updates. The flooring, room doors, walls, ect all all very old and is indicative of the hotel's age. That said, I enjoyed my ..."

Reviewed on Jul 8, 2025

Crowne Plaza San Francisco Airport by IHG
Hotel Caza Fisherman's Wharf
Hotel Caza Fisherman's Wharf
4 out of 5
1300 Columbus Avenue, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (3,639 reviews)
"Excellent stay!"

Reviewed on Jul 7, 2025

Hotel Caza Fisherman's Wharf
Soma House
Soma House
3.5 out of 5
121 7th Street, San Francisco, CA
  • 22 min drive from South San Francisco Convention Center
Stay at this 3.5-star hotel in San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms ...
7.4/10 Good! (573 reviews)
"It was an amazing experience but the only thing I wish the rooms had is a mini fridge"

Reviewed on Jul 5, 2025

Soma House
Hilton San Francisco Financial District
Hilton San Francisco Financial District
4 out of 5
750 Kearny St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (1,429 reviews)
"Staff was very nice and property was very clean"

Reviewed on Jul 7, 2025

Hilton San Francisco Financial District
Hotel Julian
Hotel Julian
3 out of 5
940 Sutter Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Stay at this 3-star hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Popular attractions Lombard Street and Pier 39 are ...
8.6/10 Excellent! (322 reviews)
"It was a great location and very helpful staff."

Reviewed on Jul 9, 2025

Hotel Julian
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your South San Francisco hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 4,981 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $104. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $104.

How many hotels are there in South San Francisco?

With over 4,981 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $104.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.