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Hotels in South San Francisco

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Tonight Apr 26 - Apr 27Next weekend May 2 - May 4

Choose from 4997 South San Francisco Hotel Deals

Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta Select San Francisco Airport Oyster Point Waterfront
3 out of 5
1300 Veterans Blvd, South San Francisco, CA
  • 29 min walk from South San Francisco Convention Center
The price is $121 per night from May 4 to May 5
$121
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.4/10 Very Good! (1,438 reviews)
"Beautiful and comfy rooms. I would definitely stay there again."

Reviewed on Apr 24, 2025

Sonesta Select San Francisco Airport Oyster Point Waterfront
Best Western Plus Grosvenor Airport Hotel
Best Western Plus Grosvenor Airport Hotel
3 out of 5
380 S Airport Boulevard, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
The price is $113 per night from May 9 to May 10
$113
includes taxes & fees
May 9 - May 10
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
8.2/10 Very Good! (1,486 reviews)
"good"

Reviewed on Apr 25, 2025

Best Western Plus Grosvenor Airport Hotel
Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2 out of 5
326 S Airport Blvd, South San Francisco, CA
  • 4 min walk from South San Francisco Convention Center
The price is $69 per night from May 11 to May 12
$69
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
5.8/10 (2,293 reviews)
"Great freindly front desk. Easy in and out to room. Agent worked well with my needs.."

Reviewed on Apr 23, 2025

Travelodge by Wyndham San Francisco Airport North
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
The price is $140 per night from May 11 to May 12
$140
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (1,678 reviews)
"Will stay again!"

Reviewed on Apr 24, 2025

DoubleTree by Hilton San Francisco South Airport Blvd
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
2.5 out of 5
20 Airport Blvd, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
The price is $133 per night from May 11 to May 12
$133
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
8/10 Very Good! (2,042 reviews)
"Great 2 bedroom! Staff was amazing, and a Denny’s restaurant right in the from of the parking lot! No other restaurants close. The hotel is in an industrial area."

Reviewed on Apr 23, 2025

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG
Holiday Inn Golden Gateway by IHG
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $155 per night from May 26 to May 27
$155
includes taxes & fees
May 26 - May 27
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (3,882 reviews)
"I liked the size of the parking garage. There were plenty of parking spaces to choose. I think the price of parking could improve. Overall with everything else, I thought services and room were great!"

Reviewed on Apr 23, 2025

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $193 per night from May 2 to May 3
$193
includes taxes & fees
May 2 - May 3
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (6,368 reviews)
"I really enjoyed my stay here! Wonderful staff and nice accommodations. Pier 39 is very close and easy to walk to. The buffet breakfast was outstanding. The amount of food offered and the huge variety of options was above most hotels I’ve stayed at. I will definitely be staying at this hotel ..."

Reviewed on Apr 24, 2025

Hotel Riu Plaza Fisherman's Wharf
Bay Landing San Francisco Airport Hotel
Bay Landing San Francisco Airport Hotel
3 out of 5
1550 Bayshore Hwy, Burlingame, CA
  • 11 min drive from South San Francisco Convention Center
The price is $154 per night from May 11 to May 12
$154
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (4,116 reviews)
"Loved the waterway walk and view of watching airplanes land/take off from SFO, but without it being “noisy”. Front desk staff were exceptionally pleasant and friendly, and the breakfast staff were very busy, keeping everything stocked and the dining area clean. Looking forward to our next stay!"

Reviewed on Apr 25, 2025

Bay Landing San Francisco Airport Hotel
Beacon Grand, A Union Square Hotel
Beacon Grand, A Union Square Hotel
4 out of 5
450 Powell Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $216 per night from May 25 to May 26
$216
includes taxes & fees
May 25 - May 26
Stay at this 4-star historic hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,414 reviews)
"The styling was outdated"

Reviewed on Apr 26, 2025

Beacon Grand, A Union Square Hotel
Chancellor Hotel on Union Square
Chancellor Hotel on Union Square
3.5 out of 5
433 Powell St, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $116 per night from May 4 to May 5
$116
includes taxes & fees
May 4 - May 5
Stay at this 3.5-star hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (2,691 reviews)
"Everything great."

Reviewed on Apr 24, 2025

Chancellor Hotel on Union Square
Handlery Union Square Hotel
Handlery Union Square Hotel
3.5 out of 5
351 Geary St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $158 per night from May 2 to May 3
$158
includes taxes & fees
May 2 - May 3
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.6/10 Excellent! (2,343 reviews)
"Not your standard, cookie cutter room, which I really liked. Bathroom a bit smaller, but fine for us and nice to have a room with character. The historic building is beautiful, the location is great, and everything was walkable and/or near major public transit. Staff was also fabulous! I would definitely ..."

Reviewed on Apr 24, 2025

Handlery Union Square Hotel
Parc 55 San Francisco - A Hilton Hotel
Parc 55 San Francisco - A Hilton Hotel
4 out of 5
55 Cyril Magnin St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $171 per night from May 22 to May 23
$171
includes taxes & fees
May 22 - May 23
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
8.6/10 Excellent! (1,325 reviews)
"My room was nice with the exception of my pillows on the bed was musty. Two out of the four pillows had a very bad musty odor."

Reviewed on Apr 22, 2025

Parc 55 San Francisco - A Hilton Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 4,997 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $69.

How many hotels are there in South San Francisco?

With over 4,997 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.