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Hotels in South San Francisco

Choose from 4992 South San Francisco Hotel Deals

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

3 out of 5
380 S Airport Boulevard, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
8.2/10 Very Good! (1,490 reviews)
"Closer to airport"

Reviewed on Jul 20, 2025

Best Western Plus Grosvenor Airport Hotel
Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront

3 out of 5
1300 Veterans Blvd, South San Francisco, CA
  • 29 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.4/10 Very Good! (1,579 reviews)
"Great staff and very clean. The room was big and spacious. The only odd thing I would change is the TV was on the side wall not facing the bed so it was at an awkward angle to watch."

Reviewed on Jul 19, 2025

Sonesta Select San Francisco Airport Oyster Point Waterfront
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (1,755 reviews)
"Very clean."

Reviewed on Jul 19, 2025

DoubleTree by Hilton San Francisco South Airport Blvd
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
8/10 Very Good! (2,017 reviews)
"Check in was easy, staff were nice. Rooms were clean, parking was bearable and theres a Dennys right in front."

Reviewed on Jul 18, 2025

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (4,330 reviews)
"Lovely stay. Bed was confortable. I really liked the parking option as is cheaper to buy here than at the property."

Reviewed on Jul 19, 2025

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (6,593 reviews)
"Excellent"

Reviewed on Jul 20, 2025

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (1,495 reviews)
"Great location! Right next to china town and the financial district! Walk right out into the entrances of these cool areas. Very fun building. Room was amazing. Clean bright, huge window, spacious, especially compared to surrounding hotel options. Will definitely be back"

Reviewed on Jul 19, 2025

Hilton San Francisco Financial District
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
Stay at this 4-star eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,755 reviews)
"Pro: Nice king-bed room on 11th floor with outdoor balcony Con: long walk from room to single bank of elevators"

Reviewed on Jul 19, 2025

Hyatt Regency San Francisco
InterContinental Mark Hopkins by IHG

InterContinental Mark Hopkins by IHG

4 out of 5
999 California Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
Stay at this 4-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,042 reviews)
"Best customer service, amazing views, great location!"

Reviewed on Jul 18, 2025

InterContinental Mark Hopkins by IHG
Crowne Plaza San Francisco Airport by IHG

Crowne Plaza San Francisco Airport by IHG

3.5 out of 5
1177 Airport Blvd, Burlingame, CA
  • 12 min drive from South San Francisco Convention Center
Stay at this 3.5-star business-friendly hotel in Burlingame. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,915 reviews)
"Friendly staff and service"

Reviewed on Jul 18, 2025

Crowne Plaza San Francisco Airport by IHG
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

4 out of 5
1300 Columbus Avenue, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (3,660 reviews)
"It was a fun place!"

Reviewed on Jul 19, 2025

Hotel Caza Fisherman's Wharf
Soma House

Soma House

3.5 out of 5
121 7th Street, San Francisco, CA
  • 22 min drive from South San Francisco Convention Center
Stay at this 3.5-star hotel in San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms ...
7.4/10 Good! (606 reviews)
"Staff was superior and parking was only $50.00 a nite compared to 75.00 all over and 24 hr valet. 24 hr door dash where frt desk accepts for you. Parts of hotel NOT involving common area under construction but totally ok. Price was amazing"

Reviewed on Jul 19, 2025

Soma House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 4,992 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $116. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $116.

How many hotels are there in South San Francisco?

With over 4,992 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $116.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.