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Hotels in South San Francisco

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Last Minute Hot Rate® Hotel Deals in South San Francisco

We Hide Hotel Names So You Can Find 4-Star Hotels At 2-Star Prices. Choose the Location, Star Rating & Amenities. Let Hotwire Find You the Best Deal. Book Today!

Choose from 5176 South San Francisco Hotel Deals

Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2 out of 5
326 S Airport Blvd, South San Francisco, CA
  • 4 min walk from South San Francisco Convention Center
The price is $67 per night from May 27 to May 28
$67
per night
May 27 - May 28
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
6/10 (1,923 reviews)
"Great Value Super clean room and easy access"

Reviewed on May 12, 2024

Travelodge by Wyndham San Francisco Airport North
Best Western Plus Grosvenor Airport Hotel
Best Western Plus Grosvenor Airport Hotel
3 out of 5
380 S Airport Boulevard, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
The price is $83 per night from May 26 to May 27
$83
per night
May 26 - May 27
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast ...
8.2/10 Very Good! (1,206 reviews)
"The property is older, but with some upgrades. It is clean and quiet. Convenient to the airport."

Reviewed on May 12, 2024

Best Western Plus Grosvenor Airport Hotel
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
The price is $125 per night from Jun 8 to Jun 9
$125
per night
Jun 8 - Jun 9
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.2/10 Very Good! (1,566 reviews)
I’d stay there again
"Very comfortable room, very impressed. The hotel restaurant is fantastic—great food and wonderful service."

Reviewed on May 9, 2024

DoubleTree by Hilton San Francisco South Airport Blvd
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
2.5 out of 5
20 Airport Blvd, South San Francisco, CA
  • 6 min walk from South San Francisco Convention Center
The price is $90 per night from May 19 to May 20
$90
per night
May 19 - May 20
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
7.8/10 Good! (1,900 reviews)
"Hotel was good however it is right by the train tracks and the hotel is split into 2 buildings"

Reviewed on May 12, 2024

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Home2 Suites by Hilton San Francisco Airport North
Home2 Suites by Hilton San Francisco Airport North
3 out of 5
550 Gateway Blvd, South San Francisco, CA
  • 16 min walk from South San Francisco Convention Center
The price is $122 per night from Jun 1 to Jun 2
$122
per night
Jun 1 - Jun 2
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (881 reviews)
"The included continental breakfast was a great convenience, offering a variety of options to start the day. Additionally, the presence of electric car charging ports made it easy for me to charge my EV rental right on the property. The onsite laundry room was another appreciated feature. Overall, ..."

Reviewed on May 8, 2024

Home2 Suites by Hilton San Francisco Airport North
Holiday Inn Golden Gateway, an IHG Hotel
Holiday Inn Golden Gateway, an IHG Hotel
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $130 per night from May 27 to May 28
$130
per night
May 27 - May 28
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the pool ...
8.6/10 Excellent! (2,526 reviews)
"Gre"

Reviewed on May 12, 2024

Holiday Inn Golden Gateway, an IHG Hotel
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $135 per night from May 21 to May 22
$135
per night
May 21 - May 22
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (6,183 reviews)
I would recommend
"The hotel felt very safe for the area. The staff was very accommodating and the free buffet breakfast was over the top."

Reviewed on May 11, 2024

Hotel Riu Plaza Fisherman's Wharf
Club Quarters Hotel in San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
424 Clay St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
The price is $127 per night from May 26 to May 27
$127
per night
May 26 - May 27
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and ...
8.6/10 Excellent! (1,596 reviews)
Awsome
"Were accommodating and helpful with all aspects of our trip and needs!"

Reviewed on May 10, 2024

Club Quarters Hotel in San Francisco
The Westin St. Francis San Francisco on Union Square
The Westin St. Francis San Francisco on Union Square
4.5 out of 5
335 Powell Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $157 per night from May 27 to May 28
$157
per night
May 27 - May 28
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the ...
8.8/10 Excellent! (2,693 reviews)
"Big fan of Westin in general"

Reviewed on May 10, 2024

The Westin St. Francis San Francisco on Union Square
Hotel Zephyr San Francisco
Hotel Zephyr San Francisco
4 out of 5
250 Beach Street, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $174 per night from May 20 to May 21
$174
per night
May 20 - May 21
Stay at this 4-star boutique hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (1,497 reviews)
"Great location on Fisherman's wharf. Good to have gaming area and fireside seating in court yard"

Reviewed on May 9, 2024

Hotel Zephyr San Francisco
Handlery Union Square Hotel
Handlery Union Square Hotel
3.5 out of 5
351 Geary St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $139 per night from May 20 to May 21
$139
per night
May 20 - May 21
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.6/10 Excellent! (1,857 reviews)
"Was able to check in early was a live saver. Staff was great and nice my room was nice and organized. While everything was a little hilly, it’s around everything you would want."

Reviewed on May 9, 2024

Handlery Union Square Hotel
DoubleTree by Hilton Hotel Berkeley Marina
DoubleTree by Hilton Hotel Berkeley Marina
4 out of 5
200 Marina Blvd, Berkeley, CA
  • 40 min drive from South San Francisco Convention Center
The price is $140 per night from May 19 to May 20
$140
per night
May 19 - May 20
Stay at this 4-star business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8/10 Very Good! (2,096 reviews)
"Lovely property on the bay!"

Reviewed on May 10, 2024

DoubleTree by Hilton Hotel Berkeley Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in South San Francisco

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your South San Francisco hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 5,176 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $60.

How many hotels are there in South San Francisco?

With over 5,176 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to South San Francisco now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to South San Francisco right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.