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Hotels in South San Francisco

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Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2 out of 5
326 S Airport Blvd South San Francisco CA
  • 4 min walk from South San Francisco Convention Center
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
5.8/10 (2,958 reviews)
Friendly Stuff.

Reviewed on Dec 24, 2025

Travelodge by Wyndham San Francisco Airport North
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

3 out of 5
380 S Airport Boulevard South San Francisco CA
  • 6 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
8.4/10 Very Good! (1,710 reviews)
Good hotel

Reviewed on Dec 23, 2025

Best Western Plus Grosvenor Airport Hotel
Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront

3 out of 5
1300 Veterans Blvd South San Francisco CA
  • 29 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the ...
8.6/10 Excellent! (1,908 reviews)
Staff

Reviewed on Dec 24, 2025

Sonesta Select San Francisco Airport Oyster Point Waterfront
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

4 out of 5
275 S Airport Blvd South San Francisco CA
  • 1 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and a fitness center. Our guests praise the restaurant ...
8.4/10 Very Good! (2,050 reviews)
Yes

Reviewed on Dec 24, 2025

DoubleTree by Hilton San Francisco South Airport Blvd
Hotel Focus SFO

Hotel Focus SFO

3 out of 5
111 Mitchell Ave South San Francisco CA
  • 4 min walk from South San Francisco Convention Center
Stay at this hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the helpful staff ...
7.4/10 Good! (1,529 reviews)
That’s good!

Reviewed on Dec 16, 2025

Hotel Focus SFO
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 out of 5
250 Gateway Blvd South San Francisco CA
  • 12 min walk from South San Francisco Convention Center
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise ...
8.4/10 Very Good! (1,240 reviews)
Room and hotel was worth the price. They do have free drink/snack hour in the late afternoon which is great.

Reviewed on Dec 19, 2025

Embassy Suites by Hilton San Francisco Airport Oyster Point
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
  • 27 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.8/10 Excellent! (7,226 reviews)
Very nice lobby. Very clean throughout. Nice decor.Employee handing out review cards on Tuesday morning in the breakfast room was not very nice. Everything else was great!

Reviewed on Dec 23, 2025

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
  • 25 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (2,184 reviews)
Pacifico our bellman was amazing! The room was great and all super easy.

Reviewed on Dec 27, 2025

Hilton San Francisco Financial District
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill San Francisco CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,435 reviews)
Architecture, Christmas decorations are magical. Staff was exceptional. Food at restaurant and cafe was delicious, savory, fresh. Vallet workers deserve a huge applause and recognition. It was so busy yet they werent only efficient, they were so kind, patient and happy vibes. That's the magic of ...

Reviewed on Dec 24, 2025

Fairmont San Francisco
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd Berkeley CA
  • 40 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
8.2/10 Very Good! (4,015 reviews)
Y ivivivi

Reviewed on Dec 26, 2025

DoubleTree by Hilton Hotel Berkeley Marina
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

3 out of 5
701 3rd St San Francisco CA
  • 22 min drive from South San Francisco Convention Center
Stay at this hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (1,883 reviews)
Great hotel!

Reviewed on Dec 25, 2025

Hyatt Place San Francisco Downtown
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
  • 24 min drive from South San Francisco Convention Center
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (5,035 reviews)
The room was great, location was good. Food was just ok. We would stay here again.

Reviewed on Dec 27, 2025

Holiday Inn Golden Gateway by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Francisco

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 5,154 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $72. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $72.

How many hotels are there in South San Francisco?

With over 5,154 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $72.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.