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4 Star Hotels in South San Francisco

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Featured 4 Star South San Francisco Hotels

Hotel Riu Plaza Fisherman's Wharf
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min drive from South San Francisco Convention Center
The price is $228 per night from Nov 26 to Nov 27
$228
includes taxes & fees
Nov 26 - Nov 27
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $118 per night from Dec 15 to Dec 16
$118
includes taxes & fees
Dec 15 - Dec 16
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
Hilton San Francisco Financial District
Kimpton Alton Fisherman's Wharf, an IHG Hotel
4.5 out of 5
Fully refundable
  • 27 min drive from South San Francisco Convention Center
The price is $186 per night from Nov 26 to Nov 27
$186
includes taxes & fees
Nov 26 - Nov 27
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Kimpton Alton Fisherman's Wharf, an IHG Hotel
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DoubleTree by Hilton Hotel Berkeley Marina
4 out of 5
Fully refundableReserve now, pay when you stay
  • 40 min drive from South San Francisco Convention Center
The price is $127 per night from Dec 1 to Dec 2
$127
includes taxes & fees
Dec 1 - Dec 2
Stay at this 4-star business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
DoubleTree by Hilton Hotel Berkeley Marina
Hyatt Centric Fisherman's Wharf San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min drive from South San Francisco Convention Center
The price is $191 per night from Nov 27 to Nov 28
$191
includes taxes & fees
Nov 27 - Nov 28
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
Hyatt Centric Fisherman's Wharf San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $129 per night from Nov 26 to Nov 27
$129
includes taxes & fees
Nov 26 - Nov 27
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Club Quarters Hotel in San Francisco
The Westin St. Francis San Francisco on Union Square
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $221 per night from Dec 15 to Dec 16
$221
includes taxes & fees
Dec 15 - Dec 16
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the ...
The Westin St. Francis San Francisco on Union Square
Hotel Nikko San Francisco
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $221 per night from Nov 26 to Nov 27
$221
includes taxes & fees
Nov 26 - Nov 27
Stay at this 4.5-star luxury hotel in San Francisco. Enjoy free WiFi, a nightclub, and a rooftop terrace. Our guests praise the breakfast and the pool in our ...
Hotel Nikko San Francisco
Beacon Grand, A Union Square Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $218 per night from Dec 24 to Dec 25
$218
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this historic hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Beacon Grand, A Union Square Hotel
Grand Hyatt San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $202 per night from Nov 27 to Nov 28
$202
includes taxes & fees
Nov 27 - Nov 28
Book a stay at this eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Grand Hyatt San Francisco
The Clift Royal Sonesta San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $226 per night from Dec 13 to Dec 14
$226
includes taxes & fees
Dec 13 - Dec 14
Book a stay at this historic hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the bar and the ...
The Clift Royal Sonesta San Francisco
Grand Hyatt at SFO
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from South San Francisco Convention Center
The price is $334 per night from Nov 29 to Nov 30
$334
includes taxes & fees
Nov 29 - Nov 30
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
Grand Hyatt at SFO
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4-star hotels in South San Francisco

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in South San Francisco for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in South San Francisco as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag South San Francisco 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in South San Francisco starting at $118 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded South San Francisco 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.