Search for Cheap Deals on
4 Star Hotels in South San Francisco

Check Last Minute South San Francisco Hotel Deals

Tonight Jul 27 - Jul 28Next weekend Aug 2 - Aug 4

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured 4 Star South San Francisco Hotels

InterContinental Mark Hopkins, an IHG Hotel
4 out of 5
Fully refundable
  • 24 min drive from South San Francisco Convention Center
The price is $201 per night from Aug 25 to Aug 26
$201
includes taxes & fees
Aug 25 - Aug 26
Book a stay at this historic hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the comfy rooms and the ...
InterContinental Mark Hopkins, an IHG Hotel
The Westin St. Francis San Francisco on Union Square
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $224 per night from Aug 24 to Aug 25
$224
includes taxes & fees
Aug 24 - Aug 25
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the ...
The Westin St. Francis San Francisco on Union Square
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min drive from South San Francisco Convention Center
The price is $243 per night from Aug 26 to Aug 27
$243
includes taxes & fees
Aug 26 - Aug 27
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the comfy rooms and ...
Hotel Riu Plaza Fisherman's Wharf
Save an average of 15% on thousands of hotels when you're signed in
DoubleTree by Hilton Hotel Berkeley Marina
4 out of 5
Fully refundableReserve now, pay when you stay
  • 40 min drive from South San Francisco Convention Center
The price is $181 per night from Aug 1 to Aug 2
$181
includes taxes & fees
Aug 1 - Aug 2
Stay at this 4-star business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the comfy rooms in our reviews. ...
DoubleTree by Hilton Hotel Berkeley Marina
Club Quarters Hotel in San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $148 per night from Aug 4 to Aug 5
$148
includes taxes & fees
Aug 4 - Aug 5
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the overall value in ...
Club Quarters Hotel in San Francisco
Hilton San Francisco Financial District
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $148 per night from Aug 18 to Aug 19
$148
includes taxes & fees
Aug 18 - Aug 19
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
Hilton San Francisco Financial District
The Westin San Francisco Airport
4 out of 5
  • 9 min drive from South San Francisco Convention Center
The price is $136 per night from Aug 10 to Aug 11
$136
includes taxes & fees
Aug 10 - Aug 11
Book a stay at this business-friendly hotel in Millbrae. Enjoy breakfast (surcharge), a free airport shuttle, and a 24-hour fitness center. Our guests praise ...
The Westin San Francisco Airport
Hotel Zeppelin San Francisco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $187 per night from Aug 4 to Aug 5
$187
includes taxes & fees
Aug 4 - Aug 5
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Hotel Zeppelin San Francisco
Hotel Nikko San Francisco
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $220 per night from Aug 25 to Aug 26
$220
includes taxes & fees
Aug 25 - Aug 26
Stay at this hotel in San Francisco. Enjoy a nightclub, a rooftop terrace, and breakfast (surcharge). Our guests praise the comfy rooms and the overall value ...
Hotel Nikko San Francisco
Hotel Zoe Fisherman's Wharf
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min drive from South San Francisco Convention Center
The price is $198 per night from Aug 25 to Aug 26
$198
includes taxes & fees
Aug 25 - Aug 26
Book a stay at this eco-certified hotel in San Francisco. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the property condition ...
Hotel Zoe Fisherman's Wharf
San Francisco Marriott Marquis
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $221 per night from Aug 2 to Aug 3
$221
includes taxes & fees
Aug 2 - Aug 3
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
San Francisco Marriott Marquis
Hyatt Regency San Francisco
4 out of 5
Fully refundable
  • 25 min drive from South San Francisco Convention Center
The price is $250 per night from Aug 17 to Aug 18
$250
includes taxes & fees
Aug 17 - Aug 18
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the overall value and ...
Hyatt Regency San Francisco
Don't see what you're looking for?
See all available properties in South San Francisco
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in South San Francisco

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in South San Francisco for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in South San Francisco as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag South San Francisco 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in South San Francisco starting at $136 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded South San Francisco 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.