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4 Star Hotels in South San Francisco

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Tonight Sep 8 - Sep 9Next weekend Sep 13 - Sep 15

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Featured 4 Star South San Francisco Hotels

Hyatt Regency San Francisco
4 out of 5
  • 25 min drive from South San Francisco Convention Center
The price is $273 per night from Sep 13 to Sep 14
$273
includes taxes & fees
Sep 13 - Sep 14
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Hyatt Regency San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
  • 25 min drive from South San Francisco Convention Center
The price is $168 per night from Sep 20 to Sep 21
$168
includes taxes & fees
Sep 20 - Sep 21
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Club Quarters Hotel in San Francisco
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
  • 27 min drive from South San Francisco Convention Center
The price is $254 per night from Sep 20 to Sep 21
$254
includes taxes & fees
Sep 20 - Sep 21
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Hotel Riu Plaza Fisherman's Wharf
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The Westin St. Francis San Francisco on Union Square
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $235 per night from Sep 21 to Sep 22
$235
includes taxes & fees
Sep 21 - Sep 22
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the ...
The Westin St. Francis San Francisco on Union Square
DoubleTree by Hilton Hotel Berkeley Marina
4 out of 5
  • 40 min drive from South San Francisco Convention Center
The price is $181 per night from Sep 9 to Sep 10
$181
includes taxes & fees
Sep 9 - Sep 10
Stay at this 4-star business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
DoubleTree by Hilton Hotel Berkeley Marina
Kimpton Alton Fisherman's Wharf, an IHG Hotel
4.5 out of 5
  • 27 min drive from South San Francisco Convention Center
The price is $217 per night from Oct 7 to Oct 8
$217
includes taxes & fees
Oct 7 - Oct 8
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Kimpton Alton Fisherman's Wharf, an IHG Hotel
Hilton San Francisco Financial District
4 out of 5
  • 25 min drive from South San Francisco Convention Center
The price is $168 per night from Sep 29 to Sep 30
$168
includes taxes & fees
Sep 29 - Sep 30
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
Hilton San Francisco Financial District
Hotel Zeppelin San Francisco
4 out of 5
  • 24 min drive from South San Francisco Convention Center
The price is $145 per night from Oct 6 to Oct 7
$145
includes taxes & fees
Oct 6 - Oct 7
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Hotel Zeppelin San Francisco
The Westin San Francisco Airport
4 out of 5
  • 9 min drive from South San Francisco Convention Center
The price is $155 per night from Sep 21 to Sep 22
$155
includes taxes & fees
Sep 21 - Sep 22
Book a stay at this business-friendly hotel in Millbrae. Enjoy breakfast (surcharge), a free airport shuttle, and a 24-hour fitness center. Our guests praise ...
The Westin San Francisco Airport
Hyatt Regency San Francisco Airport
4 out of 5
Fully refundable
  • 11 min drive from South San Francisco Convention Center
The price is $173 per night from Sep 21 to Sep 22
$173
includes taxes & fees
Sep 21 - Sep 22
Book a stay at this family-friendly hotel in Burlingame. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
Hyatt Regency San Francisco Airport
Grand Hyatt San Francisco
4 out of 5
  • 24 min drive from South San Francisco Convention Center
The price is $218 per night from Oct 4 to Oct 5
$218
includes taxes & fees
Oct 4 - Oct 5
Book a stay at this eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Grand Hyatt San Francisco
Hotel Caza Fisherman's Wharf
4 out of 5
  • 27 min drive from South San Francisco Convention Center
The price is $252 per night from Sep 9 to Sep 10
$252
includes taxes & fees
Sep 9 - Sep 10
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
Hotel Caza Fisherman's Wharf
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in South San Francisco

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in South San Francisco for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in South San Francisco as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag South San Francisco 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in South San Francisco starting at $145 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded South San Francisco 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.