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5 Star Hotels in South San Francisco

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Featured 5 Star South San Francisco Hotels

Fairmont San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $281 per night from Nov 27 to Nov 28
$281
includes taxes & fees
Nov 27 - Nov 28
Book a stay at this spa hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the property ...
Fairmont San Francisco
Claremont Club & Spa - A Fairmont Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from South San Francisco Convention Center
The price is $349 per night from Dec 13 to Dec 14
$349
includes taxes & fees
Dec 13 - Dec 14
Book a stay at this spa hotel in Berkeley. Enjoy 3 outdoor pools, breakfast (surcharge), and a health club. Our guests praise the helpful staff and the property ...
Claremont Club & Spa - A Fairmont Hotel
Taj Campton Place
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $246 per night from Nov 26 to Nov 27
$246
includes taxes & fees
Nov 26 - Nov 27
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Taj Campton Place
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Palace Hotel, a Luxury Collection Hotel, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $296 per night from Nov 26 to Nov 27
$296
includes taxes & fees
Nov 26 - Nov 27
Book a stay at this historic hotel in San Francisco. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
Palace Hotel, a Luxury Collection Hotel, San Francisco
The Ritz-Carlton, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $507 per night from Dec 23 to Dec 24
$507
includes taxes & fees
Dec 23 - Dec 24
Stay at this 5-star luxury hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
The Ritz-Carlton, San Francisco
1 Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $416 per night from Dec 1 to Dec 2
$416
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
1 Hotel San Francisco
Four Seasons Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $488 per night from Dec 6 to Dec 7
$488
includes taxes & fees
Dec 6 - Dec 7
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Four Seasons Hotel San Francisco
Four Seasons Hotel San Francisco at Embarcadero
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $488 per night from Dec 1 to Dec 2
$488
includes taxes & fees
Dec 1 - Dec 2
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Four Seasons Hotel San Francisco at Embarcadero
Four Seasons Hotel Silicon Valley at East Palo Alto
5 out of 5
Fully refundableReserve now, pay when you stay
  • 53 min drive from South San Francisco Convention Center
The price is $359 per night from Dec 6 to Dec 7
$359
includes taxes & fees
Dec 6 - Dec 7
Stay at this 5-star luxury hotel in Palo Alto. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Four Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $460 per night from Dec 22 to Dec 23
$460
includes taxes & fees
Dec 22 - Dec 23
Stay at this 5-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff ...
The St. Regis San Francisco
The Ritz-Carlton, Half Moon Bay
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from South San Francisco Convention Center
The price is $814 per night from Dec 15 to Dec 16
$814
includes taxes & fees
Dec 15 - Dec 16
Stay at this 5-star luxury hotel in Half Moon Bay. Enjoy free WiFi, a full-service spa, and 3 restaurants. Popular attractions Half Moon Bay Golf Links and Pelican ...
The Ritz-Carlton, Half Moon Bay
Rosewood Sand Hill
5 out of 5
Fully refundableReserve now, pay when you stay
  • 49 min drive from South San Francisco Convention Center
The price is $903 per night from Dec 1 to Dec 2
$903
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury hotel in Menlo Park. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions SLAC National Accelerator Laboratory ...
Rosewood Sand Hill
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5-Star Hotel in South San Francisco

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in South San Francisco.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in South San Francisco for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $246.

  • Amenities: South San Francisco skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in South San Francisco—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on South San Francisco your way.