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5 Star Hotels in South San Francisco

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Featured 5 Star South San Francisco Hotels

Fairmont San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $247 per night from Jan 19 to Jan 20
$247
includes taxes & fees
Jan 19 - Jan 20, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the property ...
Fairmont San Francisco
Taj Campton Place
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $246 per night from Dec 29 to Dec 30
$246
includes taxes & fees
Dec 29 - Dec 30
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Taj Campton Place
Palace Hotel, a Luxury Collection Hotel, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $310 per night from Jan 1 to Jan 2
$310
includes taxes & fees
Jan 1 - Jan 2, 2025
Book a stay at this historic hotel in San Francisco. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
Palace Hotel, a Luxury Collection Hotel, San Francisco
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1 Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $393 per night from Jan 2 to Jan 3
$393
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
1 Hotel San Francisco
Four Seasons Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $488 per night from Jan 10 to Jan 11
$488
includes taxes & fees
Jan 10 - Jan 11, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Four Seasons Hotel San Francisco
The Ritz-Carlton, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $451 per night from Jan 3 to Jan 4
$451
includes taxes & fees
Jan 3 - Jan 4, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
The Ritz-Carlton, San Francisco
Four Seasons Hotel San Francisco at Embarcadero
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $488 per night from Jan 17 to Jan 18
$488
includes taxes & fees
Jan 17 - Jan 18, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Four Seasons Hotel San Francisco at Embarcadero
Claremont Club & Spa - A Fairmont Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from South San Francisco Convention Center
The price is $338 per night from Dec 31 to Jan 1
$338
includes taxes & fees
Dec 31 - Jan 1, 2025
Stay at this 5-star luxury hotel in Berkeley. Enjoy 3 outdoor pools, breakfast (surcharge), and a health club. Our guests praise the helpful staff and the property ...
Claremont Club & Spa - A Fairmont Hotel
Four Seasons Hotel Silicon Valley at East Palo Alto
5 out of 5
Fully refundableReserve now, pay when you stay
  • 53 min drive from South San Francisco Convention Center
The price is $341 per night from Jan 4 to Jan 5
$341
includes taxes & fees
Jan 4 - Jan 5, 2025
Stay at this 5-star luxury hotel in Palo Alto. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Four Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $508 per night from Jan 19 to Jan 20
$508
includes taxes & fees
Jan 19 - Jan 20, 2025
Stay at this 5-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff ...
The St. Regis San Francisco
The Ritz-Carlton, Half Moon Bay
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from South San Francisco Convention Center
The price is $910 per night from Jan 20 to Jan 21
$910
includes taxes & fees
Jan 20 - Jan 21, 2025
Stay at this 5-star luxury hotel in Half Moon Bay. Enjoy free WiFi, a full-service spa, and 3 restaurants. Popular attractions Half Moon Bay Golf Links and Pelican ...
The Ritz-Carlton, Half Moon Bay
Rosewood Sand Hill
5 out of 5
Fully refundableReserve now, pay when you stay
  • 49 min drive from South San Francisco Convention Center
The price is $902 per night from Jan 26 to Jan 27
$902
includes taxes & fees
Jan 26 - Jan 27, 2025
Stay at this 5-star luxury hotel in Menlo Park. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions SLAC National Accelerator Laboratory ...
Rosewood Sand Hill
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5-Star Hotel in South San Francisco

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in South San Francisco.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in South San Francisco for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $246.

  • Amenities: South San Francisco skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in South San Francisco—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on South San Francisco your way.