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5 Star Hotels in South San Francisco

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Featured 5 Star South San Francisco Hotels

Claremont Resort & Club
5 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in Berkeley. Enjoy 3 outdoor pools, 3 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the property ...
Opens in a new windowClaremont Resort & Club
Fairmont San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the property ...
Opens in a new windowFairmont San Francisco
Taj Campton Place
5 out of 5
  • 24 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Opens in a new windowTaj Campton Place
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Palace Hotel, a Luxury Collection Hotel, San Francisco
5 out of 5
  • 24 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Opens in a new windowPalace Hotel, a Luxury Collection Hotel, San Francisco
The Ritz-Carlton, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Opens in a new windowThe Ritz-Carlton, San Francisco
Four Seasons Hotel San Francisco
5 out of 5
  • 23 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Opens in a new windowFour Seasons Hotel San Francisco
1 Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Opens in a new window1 Hotel San Francisco
Four Seasons Hotel San Francisco at Embarcadero
5 out of 5
  • 24 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Opens in a new windowFour Seasons Hotel San Francisco at Embarcadero
Four Seasons Hotel Silicon Valley at East Palo Alto
5 out of 5
  • 53 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in Palo Alto. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Opens in a new windowFour Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
5 out of 5
  • 23 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful staff ...
Opens in a new windowThe St. Regis San Francisco
Rosewood Sand Hill
5 out of 5
Fully refundableReserve now, pay when you stay
  • 49 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in Menlo Park. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions Horse Park at Woodside and Allied ...
Opens in a new windowRosewood Sand Hill
The Ritz-Carlton, Half Moon Bay
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from South San Francisco Convention Center
Stay at this 5-star luxury hotel in Half Moon Bay. Enjoy free WiFi, a full-service spa, and 3 restaurants. Popular attractions Half Moon Bay Golf Links and Pelican ...
Opens in a new windowThe Ritz-Carlton, Half Moon Bay
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in South San Francisco

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in South San Francisco.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in South San Francisco for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $244.

  • Amenities: South San Francisco skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in South San Francisco—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on South San Francisco your way.