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5 Star Hotels in South San Francisco

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Featured 5 Star South San Francisco Hotels

Palace Hotel, a Luxury Collection Hotel, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $233 per night from May 31 to Jun 1
$233
per night
May 31 - Jun 1
Book a stay at this historic hotel in San Francisco. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
Palace Hotel, a Luxury Collection Hotel, San Francisco
Four Seasons Hotel San Francisco at Embarcadero
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $415 per night from May 23 to May 24
$415
per night
May 23 - May 24
Book a stay at this luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and ...
Four Seasons Hotel San Francisco at Embarcadero
Fairmont San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $248 per night from May 19 to May 20
$248
per night
May 19 - May 20
Book a stay at this spa hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Fairmont San Francisco
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Taj Campton Place
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $179 per night from May 19 to May 20
$179
per night
May 19 - May 20
Book a stay at this boutique hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and ...
Taj Campton Place
1 Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from South San Francisco Convention Center
The price is $319 per night from May 24 to May 25
$319
per night
May 24 - May 25
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
1 Hotel San Francisco
Claremont Club & Spa - A Fairmont Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from South San Francisco Convention Center
The price is $278 per night from May 26 to May 27
$278
per night
May 26 - May 27
Book a stay at this spa hotel in Berkeley. Enjoy 3 outdoor pools, breakfast (surcharge), and a health club. Our guests praise the helpful staff and the property ...
Claremont Club & Spa - A Fairmont Hotel
The Ritz-Carlton, San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from South San Francisco Convention Center
The price is $354 per night from May 26 to May 27
$354
per night
May 26 - May 27
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge), and room service. Our guests praise the helpful staff ...
The Ritz-Carlton, San Francisco
Four Seasons Hotel San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $415 per night from May 24 to May 25
$415
per night
May 24 - May 25
Stay at this 5-star luxury hotel in San Francisco. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Four Seasons Hotel San Francisco
Four Seasons Hotel Silicon Valley at East Palo Alto
5 out of 5
Fully refundableReserve now, pay when you stay
  • 53 min drive from South San Francisco Convention Center
The price is $316 per night from May 24 to May 25
$316
per night
May 24 - May 25
Stay at this 5-star luxury hotel in Palo Alto. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions Shoreline Amphitheatre and Palo Alto ...
Four Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from South San Francisco Convention Center
The price is $441 per night from May 18 to May 19
$441
per night
May 18 - May 19
Stay at this 5-star luxury hotel in San Francisco. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the property condition ...
The St. Regis San Francisco
Rosewood Sand Hill
5 out of 5
Fully refundableReserve now, pay when you stay
  • 49 min drive from South San Francisco Convention Center
The price is $1,030 per night from May 18 to May 19
$1,030
per night
May 18 - May 19
Stay at this 5-star luxury hotel in Menlo Park. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions SLAC National Accelerator Laboratory ...
Rosewood Sand Hill
The Ritz-Carlton, Half Moon Bay
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from South San Francisco Convention Center
The price is $769 per night from May 29 to May 30
$769
per night
May 29 - May 30
Stay at this 5-star luxury hotel in Half Moon Bay. Enjoy free WiFi, a full-service spa, and 3 restaurants. Popular attractions Half Moon Bay Golf Links and Pelican ...
The Ritz-Carlton, Half Moon Bay
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5-Star Hotel in South San Francisco

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in South San Francisco.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in South San Francisco for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $179.

  • Amenities: South San Francisco skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in South San Francisco—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on South San Francisco your way.