Hotels Near
Santa Clara

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Featured Santa Clara Hotels

Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (3,787 reviews)
"City Center"

Reviewed on Mar 27, 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG
4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (2,076 reviews)
"This was a fine place to stay before our early morning flight out of PTY. Keep in mind that the airport shuttle operates every hour on the hour only. So we took an Uber which took 15 mins and cost $11 USD. So it's close to the airport, but not that close."

Reviewed on Mar 23, 2025

Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.4/10 Good! (1,005 reviews)
"Very good"

Reviewed on Mar 28, 2025

Dreams Playa Bonita Panama - All Inclusive
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,115 reviews)
Just as described
"Fantastic stay. Clean and front desk person was great with providing details about places to visit."

Reviewed on Mar 25, 2025

Decapolis Hotel Panama City
Marriott Panama Hotel
Marriott Panama Hotel
4 out of 5
Roosevelt Ave., Allbrook Mall, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,006 reviews)
"-No way to fill sink; tremendous water waste! -Reusable glass water carafes, and drinking glasses in the rooms. Got to be more sanitary ways. -No plastic bag for the ice bucket."

Reviewed on Mar 26, 2025

Marriott Panama Hotel
Principe Hotel and Suites
Principe Hotel and Suites
3 out of 5
Via Argentina, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,281 reviews)
"Great place to stay , close to subway and via Argentina"

Reviewed on Mar 23, 2025

Principe Hotel and Suites
Riande Urban Hotel
Riande Urban Hotel
3.5 out of 5
El Cangrejo; Calle Eusebio A, Morales, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and 2 restaurants. Our guests praise the bar and the helpful staff ...
8.6/10 Excellent! (1,004 reviews)
"Nice clean property. The staff was pleasant although my Spanish is limited I had no problem communicating. Supermarkets and restaurants in walking distance. Highly recommended."

Reviewed on Mar 23, 2025

Riande Urban Hotel
W Panama
W Panama
5 out of 5
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,001 reviews)
"Amazinggg place ! Def would book again"

Reviewed on Mar 21, 2025

W Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,001 reviews)
"Love the staff"

Reviewed on Mar 24, 2025

JW Marriott Panama
The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,001 reviews)
"Noise coming from room next door through the ajoining doors."

Reviewed on Mar 19, 2025

The Westin Playa Bonita Panama
Riande Aeropuerto Hotel & Casino
Riande Aeropuerto Hotel & Casino
4 out of 5
Vía Tocumen, Entrance to Corredor Sur, Tocumen, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.4/10 Very Good! (1,802 reviews)
"Convenient to airport"

Reviewed on Mar 26, 2025

Riande Aeropuerto Hotel & Casino
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,004 reviews)
"I had a lovely stay despite a little mishap at check in, that got resolved. I loved the variety of foods they had for breakfast. Staff was lovely and friendly. Hotel was very clean. I had the city view room which was beautiful. My only thing was they didn't have a laundry, which was listed apart ..."

Reviewed on Mar 27, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Clara

Panama City is a city that has a lot going on, but you have your sights set on Santa Clara. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Clara has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Clara hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Clara underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Clara city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Clara cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Clara at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $64
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Clara hotel you want, book it, and never look back. Because your great escape is ahead of you.