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Hotels in South Indianapolis

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Comfort Inn Indianapolis South

Comfort Inn Indianapolis South

2.5 out of 5
5040 S East St Indianapolis IN
  • 26 min walk from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property ...
7/10 Good! (699 reviews)
Staff was good, rooms were very clean and breakfast was just okay.

Reviewed on Jan 1, 2026

Comfort Inn Indianapolis South
Baymont by Wyndham Indianapolis South

Baymont by Wyndham Indianapolis South

2.5 out of 5
4402 E Creek View Rd Indianapolis IN
  • 8 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (590 reviews)
I booked this room at the last minute on a Saturday, however the hotel was not sold out. Quick check in and the staff was welcoming and friendly. It's right off I-65, but that is a double edged sword as my room faced the interstate so I had noise from the constant highway traffic. I was going to ...

Reviewed on Dec 29, 2025

Baymont by Wyndham Indianapolis South
La Quinta Inn & Suites by Wyndham Indianapolis South

La Quinta Inn & Suites by Wyndham Indianapolis South

3 out of 5
5120 Victory Drive Indianapolis IN
  • 4 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.4/10 Good! (1,004 reviews)
Great check in staff

Reviewed on Jan 4, 2026

La Quinta Inn & Suites by Wyndham Indianapolis South
Bottleworks Hotel

Bottleworks Hotel

4.5 out of 5
850 Massachusetts Avenue Indianapolis IN
  • 12 min drive from University of Indianapolis
Book a stay at this luxury hotel in Indianapolis. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.8/10 Exceptional! (1,794 reviews)
We love this hotel. It's always a wonderful stay.

Reviewed on Jan 4, 2026

Bottleworks Hotel
Embassy Suites by Hilton Indianapolis North

Embassy Suites by Hilton Indianapolis North

3.5 out of 5
3912 Vincennes Rd Indianapolis IN
  • 35 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
7.8/10 Good! (1,016 reviews)
Rooms were exceptionallly clean, staff very curtious. Lobby clean and tidy, breakfast was amazing.

Reviewed on Jan 3, 2026

Embassy Suites by Hilton Indianapolis North
Ironworks Hotel Indy

Ironworks Hotel Indy

4 out of 5
2721 E 86th Street Indianapolis IN
  • 34 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free WiFi, free parking, and 4 restaurants. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,767 reviews)
I loved the unique decor.

Reviewed on Jan 7, 2026

Ironworks Hotel Indy
Courtyard by Marriott Indianapolis Downtown

Courtyard by Marriott Indianapolis Downtown

3 out of 5
601 West Washington Street Indianapolis IN
  • 10 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9/10 Wonderful! (1,026 reviews)
The staff were all exceptional and friendly. The room HVAC system wasn’t working properly. The front desk provided extra blankets and maintenance was prompt and resolved the issue.

Reviewed on Jan 5, 2026

Courtyard by Marriott Indianapolis Downtown
Omni Severin Hotel

Omni Severin Hotel

4 out of 5
40 West Jackson Place Indianapolis IN
  • 9 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful ...
9.2/10 Wonderful! (797 reviews)
The room and view were gorgeous. The mattress was absolute Heaven

Reviewed on Jan 6, 2026

Omni Severin Hotel
Sheraton Indianapolis City Centre Hotel

Sheraton Indianapolis City Centre Hotel

4 out of 5
31 W Ohio St Indianapolis IN
  • 10 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.2/10 Very Good! (1,019 reviews)
Everything was clean and we were upgrade to an executive suite, which was very nice. Fia, the bartender was excellent.

Reviewed on Jan 5, 2026

Sheraton Indianapolis City Centre Hotel
Marriott Indianapolis Downtown

Marriott Indianapolis Downtown

4 out of 5
350 W Maryland St Indianapolis IN
  • 10 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy 2 bars/lounges, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful ...
9/10 Wonderful! (1,011 reviews)
Very clean

Reviewed on Jan 1, 2026

Marriott Indianapolis Downtown
InterContinental Indianapolis by IHG

InterContinental Indianapolis by IHG

4 out of 5
17 West Market Street Indianapolis IN
  • 10 min drive from University of Indianapolis
Stay at this hotel in Indianapolis. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Popular attractions Lucas Oil Stadium and Gainbridge Fieldhouse ...
9.4/10 Exceptional! (109 reviews)
The room was spotless, beautifully appointed, and thoughtfully designed, featuring modern, upscale fixtures throughout. The lobby and restaurants were stunning, creating an inviting and stylish atmosphere from the moment you arrive. The food was delicious across the board, and the rooftop bar was ...

Reviewed on Jan 6, 2026

InterContinental Indianapolis by IHG
Hilton Garden Inn Indianapolis Downtown

Hilton Garden Inn Indianapolis Downtown

3.5 out of 5
10 East Market Street Indianapolis IN
  • 10 min drive from University of Indianapolis
Book a stay at this business-friendly hotel in Indianapolis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9/10 Wonderful! (130 reviews)
The breakfast menu was very open to different options 😋. It was fresh and delicious

Reviewed on Jan 5, 2026

Hilton Garden Inn Indianapolis Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South Indianapolis

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South Indianapolis.

Choosing the right hotel in Indiana has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South Indianapolis’s 2,383 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $74. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South Indianapolis hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South Indianapolis. No matter your reason for visiting South Indianapolis, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South Indianapolis hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South Indianapolis for as low as $74.

How many hotels are there in South Indianapolis?

With over 2,383 hotels in South Indianapolis, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $74.

How to find cheap car rentals in South Indianapolis?

Finding a cheap car rental deal in South Indianapolis is as easy as scoring cheap hotels in South Indianapolis. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.