Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,391 reviews)
"We stayed 4 nights in a King Bed suite. Everything was clean. Breakfast was delicious. Staff were friendly."

Reviewed on Apr 8, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,003 reviews)
"Great ambiance with all amenities"

Reviewed on Apr 10, 2025

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,211 reviews)
"Happy hour food! Breakfast was excellant!"

Reviewed on Apr 8, 2025

Drury Inn & Suites San Antonio Northwest Medical Center
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (5,016 reviews)
"A/C in our room was very noisy. I am a HVAC contractor so I know something is wrong with the fan blade or the fan motor. Tried to run a bit of heat when we got up in the morning but all that blew out was cold air. Otherwise, everything was clean and worked fine."

Reviewed on Apr 9, 2025

Riverwalk Plaza
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,352 reviews)
"Very nice hotel and staff was great, the only issue was our room was located near the street so construction started around 7:00 AM-if you do not need to sleep in this place was excellent."

Reviewed on Apr 9, 2025

Crockett Hotel
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
8.8/10 Excellent! (3,228 reviews)
"Great location and staff was very accomodating!"

Reviewed on Apr 7, 2025

Menger Hotel
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,513 reviews)
"Hair dryer was too far from the mirror. No tissues. My scarf disappeared. I feel it was taken by the cleaning lady."

Reviewed on Apr 4, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,286 reviews)
"This hotel is fabulous! The valet parking service was great, the restaurant open till midnight is wonderful and we walked right out the lower level onto the Riverwalk! Rooms are huge, clean and quiet. We totally enjoyed ourselves and the ambience of staying in an old fashioned art deco Bank!"

Reviewed on Apr 9, 2025

Drury Plaza Hotel San Antonio Riverwalk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,460 reviews)
Great stay!
"The stay was perfect. The room was clean and spacious. The location was great for walking to the Alamo, the riverwalk, and the alamodome."

Reviewed on Apr 8, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Grand Hyatt San Antonio River Walk
Grand Hyatt San Antonio River Walk
4 out of 5
600 E Market St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,123 reviews)
"I loved the property! It’s was beautiful. The beds were comfortable . We got two free margaritas when we checked in. I just wish I got to experience more of what the property had to offer. I came down there for a basketball game so time kinda flew by. I just didn’t like that after hours we ran into ..."

Reviewed on Apr 5, 2025

Grand Hyatt San Antonio River Walk
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (3,030 reviews)
"This was a beautiful hotel and right in the Riverwalk area San Antonio. I would definitely go back."

Reviewed on Apr 10, 2025

Hotel Contessa
Hyatt Regency Hill Country Resort & Spa
Hyatt Regency Hill Country Resort & Spa
4 out of 5
9800 Hyatt Resort Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,001 reviews)
"Never left the hotel"

Reviewed on Apr 3, 2025

Hyatt Regency Hill Country Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $102
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.