Search for Cheap Deals on
4 Star Hotels in Medical Center District

Photo by Linda Cronan

Check Last Minute Medical Center District Hotel Deals

Tonight Feb 20 - Feb 21This weekend Feb 21 - Feb 23Next weekend Feb 28 - Mar 2

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Medical Center District Hotels

The Westin Riverwalk, San Antonio
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $202 per night from Feb 21 to Feb 22
$202
includes taxes & fees
Feb 21 - Feb 22
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
The Westin Riverwalk, San Antonio
Riverwalk Plaza
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $152 per night from Feb 23 to Feb 24
$152
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
Riverwalk Plaza
Hotel Contessa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $195 per night from Feb 23 to Feb 24
$195
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Contessa
Save an average of 15% on thousands of hotels when you're signed in
Omni La Mansion del Rio
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $247 per night from Feb 27 to Feb 28
$247
includes taxes & fees
Feb 27 - Feb 28
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Omni La Mansion del Rio
Hyatt Regency Hill Country Resort & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 14 min drive from USAA Corporate Office Headquarters
The price is $362 per night from Mar 5 to Mar 6
$362
includes taxes & fees
Mar 5 - Mar 6
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean ...
Hyatt Regency Hill Country Resort & Spa
Hyatt Regency San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $289 per night from Mar 9 to Mar 10
$289
includes taxes & fees
Mar 9 - Mar 10
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...
Hyatt Regency San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $160 per night from Feb 23 to Feb 24
$160
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
AC Hotel by Marriott San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from USAA Corporate Office Headquarters
The price is $222 per night from Mar 9 to Mar 10
$222
includes taxes & fees
Mar 9 - Mar 10
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
Grand Hyatt San Antonio River Walk
Element San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $179 per night from Feb 21 to Feb 22
$179
includes taxes & fees
Feb 21 - Feb 22
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Element San Antonio Riverwalk
The Westin San Antonio North
4 out of 5
Fully refundableReserve now, pay when you stay
  • 10 min walk from USAA Corporate Office Headquarters
The price is $99 per night from Feb 23 to Feb 24
$99
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
The Westin San Antonio North
Hotel Valencia Riverwalk
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $209 per night from Feb 23 to Feb 24
$209
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Hotel Valencia Riverwalk
Canopy by Hilton San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $234 per night from Feb 27 to Feb 28
$234
includes taxes & fees
Feb 27 - Feb 28
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests ...
Canopy by Hilton San Antonio Riverwalk
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.