Search for Cheap Deals on
4 Star Hotels in Medical Center District

Photo by Linda Cronan

Check Last Minute Medical Center District Hotel Deals

Tonight Nov 23 - Nov 24Next weekend Nov 29 - Dec 1

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!

Featured 4 Star Medical Center District Hotels

Riverwalk Plaza
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $129 per night from Nov 24 to Nov 25
$129
includes taxes & fees
Nov 24 - Nov 25
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
Riverwalk Plaza
Omni La Mansion del Rio
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $223 per night from Nov 25 to Nov 26
$223
includes taxes & fees
Nov 25 - Nov 26
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Omni La Mansion del Rio
Hotel Contessa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $196 per night from Dec 15 to Dec 16
$196
includes taxes & fees
Dec 15 - Dec 16
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Contessa
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Hotel Gibbs Downtown Riverwalk
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $136 per night from Nov 28 to Nov 29
$136
includes taxes & fees
Nov 28 - Nov 29
Stay at this 4.5-star luxury aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hotel Gibbs Downtown Riverwalk
Canopy by Hilton San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $223 per night from Dec 15 to Dec 16
$223
includes taxes & fees
Dec 15 - Dec 16
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests ...
Canopy by Hilton San Antonio Riverwalk
Hyatt Regency Hill Country Resort & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 14 min drive from USAA Corporate Office Headquarters
The price is $227 per night from Nov 24 to Nov 25
$227
includes taxes & fees
Nov 24 - Nov 25
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
Hyatt Regency Hill Country Resort & Spa
Hotel Valencia Riverwalk
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $225 per night from Dec 1 to Dec 2
$225
includes taxes & fees
Dec 1 - Dec 2
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Hotel Valencia Riverwalk
InterContinental San Antonio Riverwalk, an IHG Hotel
4.5 out of 5
Fully refundable
  • 19 min drive from USAA Corporate Office Headquarters
The price is $201 per night from Dec 18 to Dec 19
$201
includes taxes & fees
Dec 18 - Dec 19
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Popular attractions Alamo and River Walk are located ...
InterContinental San Antonio Riverwalk, an IHG Hotel
Hyatt Regency San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $233 per night from Nov 26 to Nov 27
$233
includes taxes & fees
Nov 26 - Nov 27
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...
Hyatt Regency San Antonio Riverwalk
The Maverick, powered by Placemakr - River Walk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $127 per night from Dec 2 to Dec 3
$127
includes taxes & fees
Dec 2 - Dec 3
Stay at this 4-star hotel in San Antonio. Enjoy free breakfast, free WiFi, and valet parking (surcharge). Our guests praise the helpful staff in our reviews. ...
The Maverick, powered by Placemakr - River Walk
AC Hotel by Marriott San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $139 per night from Nov 25 to Nov 26
$139
includes taxes & fees
Nov 25 - Nov 26
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
AC Hotel by Marriott San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from USAA Corporate Office Headquarters
The price is $220 per night from Nov 26 to Nov 27
$220
includes taxes & fees
Nov 26 - Nov 27
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
Grand Hyatt San Antonio River Walk
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.