Search for Cheap Deals on
4 Star Hotels in Medical Center District

Photo by Linda Cronan

Check Last Minute Medical Center District Hotel Deals

Tonight Jan 11 - Jan 12Next weekend Jan 17 - Jan 19

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!

Featured 4 Star Medical Center District Hotels

Riverwalk Plaza
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $110 per night from Jan 12 to Jan 13
$110
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
Riverwalk Plaza
Hotel Contessa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $180 per night from Jan 20 to Jan 21
$180
includes taxes & fees
Jan 20 - Jan 21
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Contessa
Omni La Mansion del Rio
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $213 per night from Jan 12 to Jan 13
$213
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Omni La Mansion del Rio
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Hyatt Regency San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $270 per night from Jan 12 to Jan 13
$270
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...
Hyatt Regency San Antonio Riverwalk
The Westin Riverwalk, San Antonio
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $201 per night from Jan 12 to Jan 13
$201
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
The Westin Riverwalk, San Antonio
The St. Anthony, A Luxury Collection Hotel, San Antonio
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $254 per night from Jan 17 to Jan 18
$254
includes taxes & fees
Jan 17 - Jan 18
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
The St. Anthony, A Luxury Collection Hotel, San Antonio
AC Hotel by Marriott San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $135 per night from Jan 13 to Jan 14
$135
includes taxes & fees
Jan 13 - Jan 14
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
AC Hotel by Marriott San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from USAA Corporate Office Headquarters
The price is $213 per night from Jan 12 to Jan 13
$213
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
Grand Hyatt San Antonio River Walk
Hilton San Antonio Hill Country
4 out of 5
Fully refundableReserve now, pay when you stay
  • 14 min drive from USAA Corporate Office Headquarters
The price is $115 per night from Feb 9 to Feb 10
$115
includes taxes & fees
Feb 9 - Feb 10
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and breakfast (surcharge). Our guests praise the helpful staff and ...
Hilton San Antonio Hill Country
The Westin San Antonio North
4 out of 5
Fully refundableReserve now, pay when you stay
  • 10 min walk from USAA Corporate Office Headquarters
The price is $139 per night from Jan 19 to Jan 20
$139
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
The Westin San Antonio North
Canopy by Hilton San Antonio Riverwalk
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $233 per night from Jan 13 to Jan 14
$233
includes taxes & fees
Jan 13 - Jan 14
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests ...
Canopy by Hilton San Antonio Riverwalk
Hotel Valencia Riverwalk
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from USAA Corporate Office Headquarters
The price is $189 per night from Jan 15 to Jan 16
$189
includes taxes & fees
Jan 15 - Jan 16
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Hotel Valencia Riverwalk
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.