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Featured 4 Star Medical Center District Hotels

Fully refundableReserve now, pay when you stay
The price is $141 per night from Apr 13 to Apr 14
$141
includes taxes & fees
Apr 13 - Apr 14
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...

Fully refundableReserve now, pay when you stay
The price is $226 per night from Apr 20 to Apr 21
$226
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...

Fully refundableReserve now, pay when you stay
The price is $216 per night from May 4 to May 5
$216
includes taxes & fees
May 4 - May 5
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
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Fully refundableReserve now, pay when you stay
The price is $257 per night from Apr 20 to Apr 21
$257
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...

Fully refundableReserve now, pay when you stay
The price is $189 per night from Apr 17 to Apr 18
$189
includes taxes & fees
Apr 17 - Apr 18
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...

Fully refundableReserve now, pay when you stay
The price is $233 per night from Apr 20 to Apr 21
$233
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...

Fully refundableReserve now, pay when you stay
The price is $227 per night from May 4 to May 5
$227
includes taxes & fees
May 4 - May 5
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests ...

Fully refundableReserve now, pay when you stay
The price is $241 per night from Apr 20 to Apr 21
$241
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff in our ...

Fully refundableReserve now, pay when you stay
The price is $215 per night from May 5 to May 6
$215
includes taxes & fees
May 5 - May 6
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...

Fully refundable
The price is $269 per night from Apr 20 to Apr 21
$269
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Popular attractions San Antonio River and Alamo ...

Fully refundableReserve now, pay when you stay
The price is $141 per night from May 4 to May 5
$141
includes taxes & fees
May 4 - May 5
Stay at this 4-star hotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff ...

Fully refundableReserve now, pay when you stay
The price is $133 per night from Apr 20 to Apr 21
$133
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
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See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular Medical Center District Hotels
- La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
- San Antonio Marriott Northwest Medical Center
- Riverwalk Plaza
- Crockett Hotel
- Menger Hotel
- La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
- Sonesta ES Suites San Antonio Downtown Alamo Plaza
- Grand Hyatt San Antonio River Walk
- Hotel Contessa
- Hyatt Regency Hill Country Resort & Spa
Top Attractions in Medical Center District
- Hotels near USAA Corporate Office Headquarters (2.34 mi)
- Hotels near South Texas Medical Center (0.35 mi)
- Hotels near University of Texas Health and Science Center at San Antonio (0.21 mi)
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center (0.86 mi)
- Hotels near Oak Hills Country Club (0.83 mi)
- Hotels near The San Antonio Art Institute (1.96 mi)
- Hotels near River Walk (7.85 mi)
- Hotels near Lackland Air Force Base (8.68 mi)
- Hotels near Six Flags Fiesta Texas (6.74 mi)
- Hotels near Alamo (7.78 mi)
- Hotels near Henry B. González Convention Center (7.98 mi)
- Hotels near San Antonio River (7.6 mi)
- Hotels near San Antonio Zoo and Aquarium (6.87 mi)
- Hotels near Frost Bank Center (9.97 mi)
- Hotels near The Shops of La Cantera (6.41 mi)
- Hotels near Alamodome (8.61 mi)
Nearby Cities
- New Braunfels Hotels (30.36 mi)
- Boerne Hotels (21.98 mi)
- Hill Country Hotels (68.54 mi)
- Schertz Hotels (18.72 mi)
- Gulf Coast Hotels (306.58 mi)
- Helotes Hotels (8.4 mi)
- Bulverde Hotels (18.01 mi)
- Spring Branch Hotels (25.15 mi)
- Universal City Hotels (17.41 mi)
- Converse Hotels (15.69 mi)
- Selma Hotels (17.15 mi)
- Castroville Hotels (20.91 mi)
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