Search for Cheap Deals on5 Star Hotels in Otay Mesa West
Photo by Leonardo De Leon
Check Last Minute Otay Mesa West Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured 5 Star Otay Mesa West Hotels

Fully refundableReserve now, pay when you stay
The price is $338 per night from Mar 23 to Mar 24
$338
includes taxes & fees
Mar 23 - Mar 24
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...

Fully refundableReserve now, pay when you stay
The price is $315 per night from Mar 23 to Mar 24
$315
includes taxes & fees
Mar 23 - Mar 24
Stay at this 5-star luxury hotel in San Diego. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise the helpful ...

The price is $1,067 per night from Mar 12 to Mar 13
$1,067
includes taxes & fees
Mar 12 - Mar 13
Stay at this 5-star luxury resort in Coronado. Enjoy free WiFi, 3 outdoor pools, and 7 restaurants. Popular attractions Petco Park and USS Midway Museum are ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Otay Mesa West
Popular Otay Mesa West Hotels
- The Dana on Mission Bay
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- San Diego Mission Bay Resort
- Comfort Inn Sea World Area
- Wyndham San Diego Bayside
- Omni San Diego Hotel
- The Little Italy Hotel Downtown San Diego
- Sheraton San Diego Resort
- Humphreys Half Moon Inn
- Hard Rock Hotel San Diego
- Best Western Seven Seas
- Sheraton Mission Valley San Diego Hotel
Top Attractions in Otay Mesa West
- Hotels near San Diego Zoo (12.29 mi)
- Hotels near Mission Bay (17.06 mi)
- Hotels near San Ysidro Border Crossing (2.74 mi)
- Hotels near San Diego Convention Center (10.87 mi)
- Hotels near Balboa Park (11.88 mi)
- Hotels near Mission Beach (17.63 mi)
- Hotels near San Diego State University (13.58 mi)
- Hotels near Marine Corps Recruit Depot (13.97 mi)
- Hotels near Port of San Diego (11.85 mi)
- Hotels near Petco Park (10.76 mi)
- Hotels near Hotel del Coronado (10.11 mi)
- Hotels near Hotel Circle (14.43 mi)
- Hotels near B Street Cruise Ship Terminal (11.92 mi)
- Hotels near Mission Beach Boardwalk (17.18 mi)
- Hotels near Naval Base San Diego (7.94 mi)
- Hotels near Naval Base Coronado (12.2 mi)
- Hotels near USS Midway Museum (11.73 mi)
- Hotels near Coronado Beach (10.63 mi)
- Hotels near University of San Diego (15.6 mi)
- Hotels near Sycuan Casino (19.4 mi)
Nearby Cities
- San Diego Hotels (11.38 mi)
- La Jolla Hotels (21.67 mi)
- Coronado Hotels (10.58 mi)
- Chula Vista Hotels (4.65 mi)
- Playas de Rosarito Hotels (24.36 mi)
- Rosarito Hotels (14.61 mi)
- Coronado Island Hotels (11.64 mi)
- El Cajon Hotels (15.92 mi)
- Southern California Hotels (89.06 mi)
- National City Hotels (7.41 mi)
- La Mesa Hotels (13.26 mi)
- Imperial Beach Hotels (3.44 mi)
Recommended cities for you
- Las Vegas Hotels
- New York Hotels
- Orlando Hotels
- Los Angeles Hotels
- Miami Hotels
- San Francisco Hotels
- New Orleans Hotels
- Chicago Hotels
- Fort Lauderdale Hotels
- Boston Hotels
- Honolulu Hotels
- San Diego Hotels
- Washington Hotels
- Toronto Hotels
- Anaheim Hotels
- Atlanta Hotels
- Nashville Hotels
- Seattle Hotels
- Phoenix Hotels
- Myrtle Beach Hotels
Car Rentals Near Otay Mesa West
- Car rentals in San Diego
- Car rentals in La Jolla
- Car rentals in Coronado
- Car rentals in Chula Vista
- Car rentals in Playas de Rosarito
- Car rentals in Rosarito
- Car rentals in Coronado Island
- Car rentals in El Cajon
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in La Mesa
- Car rentals in Imperial Beach
- Car rentals in San Ysidro
- Car rentals in Alpine
- Car rentals in Santee
- Car rentals in Spring Valley