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Hotels in Big Talbot Island State Park

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Choose from 4305 Big Talbot Island State Park Hotel Deals

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free WiFi, a beach locale, and breakfast (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,557 reviews)
Wish it had indoor pool and later bar hours

Reviewed on Jan 26, 2026

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr Jacksonville FL
  • 19 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,446 reviews)
Mr. Yancy at the front desk. He was excellent. Very nice and polite. I will be back to stay again.

Reviewed on Jan 25, 2026

Hyatt Regency Jacksonville
The Villas of Amelia Island

The Villas of Amelia Island

4 out of 5
8 Amelia Village Circle, Amelia Island Fernandina Beach FL
  • 46 min drive from Mayo Clinic Florida
Book a stay at this beach vacation home in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in ...
8.4/10 Very Good! (1,148 reviews)
Beautiful grounds, very helpful staff, great amenities. Cedric the tram driver was the highlight of our trip! Great stories, helpful suggestions about where to eat and such a pleasant perspective! The shops are wonderful with unique clothing and accessories.

Reviewed on Jan 14, 2026

The Villas of Amelia Island
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

3.5 out of 5
1515 Prudential Dr Jacksonville FL
  • 18 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,641 reviews)
The friendly staff! The best bar staff ever! AWESOME!

Reviewed on Jan 25, 2026

Southbank Hotel by Marriott Jacksonville Riverwalk
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

3 out of 5
14565 Duval Rd Jacksonville FL
  • 40 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,359 reviews)
Yes

Reviewed on Jan 22, 2026

Hyatt Place Jacksonville Airport
Amelia Hotel at the Beach

Amelia Hotel at the Beach

2.5 out of 5
1997 S Fletcher Ave Fernandina Beach FL
  • 1 hour drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Fernandina Beach. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and ...
8.4/10 Very Good! (2,139 reviews)
El hotel esta enfrente de la playa La habitacion estaba limpia y super comoda Ofrecian 4

Reviewed on Jan 24, 2026

Amelia Hotel at the Beach
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,798 reviews)
Was clean room. Staff was friendly

Reviewed on Jan 26, 2026

Wyndham Garden Jacksonville
San Marco Inn East

San Marco Inn East

3 out of 5
3558 Phillips Hwy Jacksonville FL
  • 14 min drive from Mayo Clinic Florida
Stay at this motel in Jacksonville. Enjoy free WiFi, free parking, and 24-hour room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (1,360 reviews)
Clean and polite

Reviewed on Jan 21, 2026

San Marco Inn East
Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport

2.5 out of 5
15678 Max Leggett Parkway Jacksonville FL
  • 41 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jacksonville Zoo and Gardens ...
8.6/10 Excellent! (201 reviews)
Room was spotless, Great staff.

Reviewed on Jan 23, 2026

Extended Stay America Premier Suites - Jacksonville - Airport
Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
39 Beach Lagoon Road Fernandina Beach FL
  • 49 min drive from Mayo Clinic Florida
Book a stay at this beach resort in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (1,003 reviews)
Clean, remodeled, friendly staff!

Reviewed on Jan 22, 2026

Omni Amelia Island Resort & Spa
Best Western Oceanfront

Best Western Oceanfront

3 out of 5
305 1st St N Jacksonville Beach FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free breakfast, free WiFi, and a beach locale. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,002 reviews)
A

Reviewed on Jan 21, 2026

Best Western Oceanfront
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
1201 Riverplace Boulevard Jacksonville FL
  • 18 min drive from Mayo Clinic Florida
Stay at this hotel in Jacksonville. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. Popular ...
6.6/10 (1,559 reviews)
Our room attendant ( house keeping) Was vert attentive and took care to ensure we had all we needed. The valet provided exceptional service delivering my oackages

Reviewed on Jan 23, 2026

DoubleTree by Hilton Hotel Jacksonville Riverfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Big Talbot Island State Park

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $70. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Big Talbot Island State Park hotel deals at the last minute.

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Frequently Asked Questions About Big Talbot Island State Park hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Big Talbot Island State Park?

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Finding a cheap car rental deal in Big Talbot Island State Park is as easy as scoring cheap hotels in Big Talbot Island State Park. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.