Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,148 reviews)
"Friendly staff"

Reviewed on Dec 22, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,003 reviews)
"Everyone was nice."

Reviewed on Dec 21, 2024

Courtyard by Marriott Medical Center San Antonio
Clarion Pointe near Medical Center
Clarion Pointe near Medical Center
2.5 out of 5
4803 Manitou, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,492 reviews)
"Clean room and quiet"

Reviewed on Dec 22, 2024

Clarion Pointe near Medical Center
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,004 reviews)
"The rooms and staff were very nice. The complementary cucumber and lemon water was very good as was the coffee in the morning. We stayed for the night with our future sailor. God bless our men and women of the armed forces."

Reviewed on Dec 18, 2024

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,173 reviews)
Would stay again!
"Its a very decent hotel for the price and very close to many restaurants and H-E-B."

Reviewed on Dec 17, 2024

Drury Inn & Suites San Antonio Northwest Medical Center
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundable
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.6/10 (1,006 reviews)
Nice
"Rooms were a little small but very clean"

Reviewed on Dec 21, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8.2/10 Very Good! (4,395 reviews)
"Very central and reasonable price, except valet parking cost is too high"

Reviewed on Dec 22, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,273 reviews)
"Ok"

Reviewed on Dec 22, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
8.8/10 Excellent! (3,123 reviews)
"plaza construction underway"

Reviewed on Dec 22, 2024

Menger Hotel
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,942 reviews)
"This hotel was the best hotel by far I have stayed in. Wonderful customer service!"

Reviewed on Dec 22, 2024

Hotel Contessa
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,756 reviews)
"This place was so good"

Reviewed on Dec 21, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Omni La Mansion del Rio
Omni La Mansion del Rio
4 out of 5
112 College St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (2,391 reviews)
"had a good view of the courtyard"

Reviewed on Dec 22, 2024

Omni La Mansion del Rio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $55
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.