Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,378 reviews)
"Great stay"

Reviewed on Apr 3, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,005 reviews)
"Comfortable and convenient"

Reviewed on Apr 3, 2025

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,215 reviews)
Drury Inn
"The free Kick Back with 3 drinks and food was enjoyable. The only thing that could have been better was for me hotel to be farther from the freeway"

Reviewed on Apr 4, 2025

Drury Inn & Suites San Antonio Northwest Medical Center
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (4,981 reviews)
"It was a nice place, great location, fun bartender."

Reviewed on Apr 4, 2025

Riverwalk Plaza
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,348 reviews)
Great stay
"Great older, historic hotel named after Davey Crockett. Tavern was great, good food and very friendly service by Melissa. Will stay again!"

Reviewed on Apr 2, 2025

Crockett Hotel
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,450 reviews)
"Great property for the price. Very good location close to the Alamo and Riverwalk."

Reviewed on Apr 2, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,519 reviews)
"Hair dryer was too far from the mirror. No tissues. My scarf disappeared. I feel it was taken by the cleaning lady."

Reviewed on Apr 4, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,261 reviews)
"The staff was very friendly and always ready to help answers any questions. The breakfast was standard and the afternoon snacks were tasty. It was so convenient being able to step out on to the Riverwalk, everything felt very safe. I would definitely stay at this location again."

Reviewed on Apr 3, 2025

Drury Plaza Hotel San Antonio Riverwalk
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
8.8/10 Excellent! (3,238 reviews)
"Great veiw and esthetic"

Reviewed on Apr 4, 2025

Menger Hotel
Grand Hyatt San Antonio River Walk
Grand Hyatt San Antonio River Walk
4 out of 5
600 E Market St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,116 reviews)
"The Grand Hyatt is amazing! Will definitely stay there again when we go back!!!"

Reviewed on Apr 3, 2025

Grand Hyatt San Antonio River Walk
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (3,020 reviews)
"Great location, nice place."

Reviewed on Apr 3, 2025

Hotel Contessa
Hyatt Regency Hill Country Resort & Spa
Hyatt Regency Hill Country Resort & Spa
4 out of 5
9800 Hyatt Resort Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,002 reviews)
"Never left the hotel"

Reviewed on Apr 3, 2025

Hyatt Regency Hill Country Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $105
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.