Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,092 reviews)
"Have stayed here iften. Comfortable rooms decent hot breakfast. Great rates, paid average of 75 a nighg for a weekend stay. Almost unheard of in San Antonio."

Reviewed on Nov 22, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,003 reviews)
"Very clean"

Reviewed on Nov 20, 2024

Courtyard by Marriott Medical Center San Antonio
Clarion Pointe near Medical Center
Clarion Pointe near Medical Center
2.5 out of 5
4803 Manitou, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,462 reviews)
Dissatisfied
"I was charged and extra 60 dlls for room deposit that is not stated on the site . It's already 3 days and waiting for a refund of those 60 dlls I had stayed there before and it was not like that in the first place . Their breakfast is not as it used to be ... They have a set breakfast and it's not ..."

Reviewed on Nov 20, 2024

Clarion Pointe near Medical Center
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,000 reviews)
"Love this location . Staff is always so professional and pleasant . Rooms r clean and decorated nicely. We never stay anywhere else."

Reviewed on Nov 14, 2024

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,178 reviews)
"Easy reservation, clean, & tidy"

Reviewed on Nov 18, 2024

Drury Inn & Suites San Antonio Northwest Medical Center
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundable
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our ...
6.6/10 (1,001 reviews)
"Great service"

Reviewed on Nov 6, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (4,283 reviews)
"Loved how nice and clean the room was! Will forsure stay here again!:)"

Reviewed on Nov 21, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,201 reviews)
Registration process and good support
"Good registration service."

Reviewed on Nov 22, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (2,136 reviews)
"The staff members are extremely nice. We dined at the Crockett Tavern and we loved the atmosphere."

Reviewed on Nov 22, 2024

Crockett Hotel
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,084 reviews)
Menger King Suite
"Awesome room. We stayed an extra night. 👍"

Reviewed on Nov 22, 2024

Menger Hotel
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,746 reviews)
"I was greeted in a not-so-friendly manner by the desk person. I asked a question for clarity and she was condescending to me. I’ve been at the location before and received great service. The person who was there the morning I checked in was subpar."

Reviewed on Nov 22, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,906 reviews)
"Friendly staff. Clean and beautiful hotel. My wife and I will be coming back in Jan."

Reviewed on Nov 21, 2024

Hotel Contessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $56
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.