Hotels NearMedical Center District
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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Staff was great. Room was clean. Only negative was that they charge to park. I don't understand why they charge their own guests to park.
Reviewed on Nov 2, 2025

San Antonio Marriott Northwest Medical Center
Everything was good
Reviewed on Oct 27, 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Staff was helpful! Everything super clean and free breakfast was good
Reviewed on Nov 2, 2025

Courtyard by Marriott Medical Center San Antonio
Over all very quiet peaceful stay
Reviewed on Oct 19, 2025

Hotel Valencia Riverwalk
Hotel Valencia was one of the best hoteles we have stayed at. The staff was fantastic
Reviewed on Oct 27, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Convenient to the Convention Center and the Riverwalk while still being affordable.
Reviewed on Nov 2, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Everything was good. Excellent location
Reviewed on Nov 2, 2025

Drury Plaza Hotel San Antonio Riverwalk
We loved everything about our stay there. Loved that the buffet breakfast was included as well as the afternoon "happy hour" & all that was included with that. Staff was VERY helpful. Would definitely stay there again!
Reviewed on Oct 29, 2025

Riverwalk Plaza
While we were out two waters ended up in the trash empty, I know it sounds crazy but they are $20 a bottle and we absolutely did not drink them! Went to the manager who was the house keeping manager and was told no one went in while we were gone. Waiting to see if we get charged for them… I was told ...
Reviewed on Nov 3, 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
My kid are ten and six and always have a wonderful time here.
Reviewed on Nov 2, 2025

Hotel Contessa
Room was quiet and it was easy to connect my phone to the tv’s to watch what I wanted in the evenings.
Reviewed on Nov 2, 2025

Spark By Hilton San Antonio Northwest near Six Flags
Ac wasn’t that cold even after setting it at 60 and the hot water in the shower was never hot. Other then that the stay was great
Reviewed on Nov 2, 2025
Hotels in Medical Center District
San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $66
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.
Medical Center District Neighborhoods
Top Attractions in Medical Center District
- Hotels near USAA Corporate Office Headquarters (2.34 mi)
- Hotels near South Texas Medical Center (0.35 mi)
- Hotels near University of Texas Health and Science Center at San Antonio (0.21 mi)
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center (0.86 mi)
- Hotels near Oak Hills Country Club (0.83 mi)
- Hotels near The San Antonio Art Institute (1.96 mi)
- Hotels near River Walk (7.85 mi)
- Hotels near Lackland Air Force Base (8.68 mi)
- Hotels near Six Flags Fiesta Texas (6.74 mi)
- Hotels near Alamodome (8.61 mi)
- Hotels near Alamo (7.78 mi)
- Hotels near Henry B. González Convention Center (7.98 mi)
- Hotels near San Antonio Zoo and Aquarium (6.87 mi)
- Hotels near San Antonio River (7.6 mi)
- Hotels near Frost Bank Center (9.97 mi)
- Hotels near Market Square (7.28 mi)
Cities near Medical Center District
- New Braunfels Hotels (30.36 mi)
- Boerne Hotels (21.98 mi)
- Hill Country Hotels (68.54 mi)
- Schertz Hotels (18.72 mi)
- Helotes Hotels (8.4 mi)
- Spring Branch Hotels (25.15 mi)
- Castroville Hotels (20.91 mi)
- Universal City Hotels (17.41 mi)
- Bulverde Hotels (18.01 mi)
- Converse Hotels (15.69 mi)
- Selma Hotels (17.15 mi)
- Cibolo Hotels (21.05 mi)
- Elmendorf Hotels (22.67 mi)
- Pipe Creek Hotels (26.19 mi)
- Lytle Hotels (23.08 mi)
- South Texas Hotels (94.36 mi)
- North San Antonio - SAT Hotels (8.06 mi)
- West Texas Hotels (215.71 mi)
- Von Ormy Hotels (15.74 mi)
- Northwest San Antonio Hotels (7.2 mi)
