Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,293 reviews)
"Great Location great room"

Reviewed on Mar 5, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,008 reviews)
"Great place to stay will definitely stay again"

Reviewed on Mar 2, 2025

San Antonio Marriott Northwest Medical Center
Clarion Pointe near Medical Center
Clarion Pointe near Medical Center
2.5 out of 5
4803 Manitou, San Antonio, TX
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,572 reviews)
"Great stay thank you"

Reviewed on Mar 3, 2025

Clarion Pointe near Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,221 reviews)
"The location was conveniet"

Reviewed on Mar 3, 2025

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,001 reviews)
"I liked that my friend and I were given rooms next to each other. I liked the opportunity to be able to park right next to our rooms. But my friend was very upset that there was NO complementary coffee or breakfast pastries. For the price of each nightly stay, you would think that fresh brewed coffee ..."

Reviewed on Mar 2, 2025

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (4,788 reviews)
"Beautiful hotel"

Reviewed on Mar 5, 2025

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,449 reviews)
Live the hotel
"We had a great experience at the hotel. We will be back again."

Reviewed on Feb 27, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
Grand Hyatt San Antonio River Walk
4 out of 5
600 E Market St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,100 reviews)
"We had a great time!! My son loved the workout room and heated pool!"

Reviewed on Feb 28, 2025

Grand Hyatt San Antonio River Walk
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,999 reviews)
"We enjoyed our 2-day stay. Situated right on thr riverwalk, and close to everything, we enjoyed walking to the things we needed to see. The food at Ambler restaurant was very good."

Reviewed on Mar 4, 2025

Hotel Contessa
Hotel Valencia Riverwalk
Hotel Valencia Riverwalk
4.5 out of 5
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9.2/10 Wonderful! (1,859 reviews)
"What amazing hotel. Incredible rooms and great hospitality."

Reviewed on Mar 3, 2025

Hotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,161 reviews)
"Excellent accommodation and staff. Very pleasant staff who work very well with the amount of guests they attend to. Definitely a stay again."

Reviewed on Mar 4, 2025

Drury Plaza Hotel San Antonio Riverwalk
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
8.8/10 Excellent! (3,213 reviews)
Good old style hotel
"All good , receptionist ok if a little indifferent"

Reviewed on Mar 2, 2025

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $105
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.