Hotels Near
Medical Center District

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Featured Medical Center District Hotels

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundable
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
6.8/10 (1,414 reviews)
So so …
"Stay was good. Just upon arrival. We were told that they weren’t issuing rooms yes(arrived 15 minutes early) so we proceeded to wait in the diner where most people were waiting. Around 3 we were not told they were ready to issue rooms instead people who were just arriving were being attended ..."

Reviewed on May 21, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (3,005 reviews)
No safe car parking
"There was no parking in the front of the hotel. I had to park in the back. When I checked out in the morning the cars that were parked on the back on the other side of mine were broken into!! Several broken car windows!!! Beware"

Reviewed on May 21, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (1,000 reviews)
"Nice location"

Reviewed on May 20, 2024

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (3,573 reviews)
"Loved the room - it was clean & comfy."

Reviewed on May 21, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
7.4/10 Good! (2,661 reviews)
"Buen hotel solo poco mas de mantenimiento"

Reviewed on May 21, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,577 reviews)
"Nothing special. Just a typical hotel room."

Reviewed on May 20, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the pool in ...
8.8/10 Excellent! (2,828 reviews)
"Beautiful property. Close to everything."

Reviewed on May 22, 2024

Menger Hotel
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (2,845 reviews)
Will not go to this hotel again.
"Its been a while since I last stayed in a hotel. Things have changed. I was very surprised that there was a $42 valet parking charge for a one night stay. The room was so small I could not get the luggage cart into the room....seriously. I had to unload the cart by straddling it in the doorway."

Reviewed on May 22, 2024

Hotel Gibbs Downtown Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,705 reviews)
nice hotel but High parking rates.
"nice and convenient hotel, but watch out for those parking rates. 40.00 per night !"

Reviewed on May 21, 2024

Crockett Hotel
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,728 reviews)
"We went for fiesta week and the opportunities for entertainment were wonderful and services available. We utilize them all. my daughter were on a mother-daughter trip. I would definitely stay at the Hotel Contessa again"

Reviewed on May 22, 2024

Hotel Contessa
Hyatt Regency San Antonio Riverwalk
Hyatt Regency San Antonio Riverwalk
4 out of 5
123 Losoya St, San Antonio, TX
Fully refundable
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,594 reviews)
"Location"

Reviewed on May 21, 2024

Hyatt Regency San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,599 reviews)
"Everything was great no loudness which was great for resting"

Reviewed on May 21, 2024

Drury Plaza Hotel San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $67
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.