Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,509 reviews)
"Nice facility but could improve on gym equipment maintenance."

Reviewed on May 13, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,014 reviews)
"No shuttle service available on weekends. Main reason I stayed here."

Reviewed on May 17, 2025

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,230 reviews)
"Excellent. Service is extremely good"

Reviewed on May 13, 2025

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,002 reviews)
Amazing Stay!!!
"The staff were very helpful, welcoming and friendly!! I truly enjoyed our stay both times. The rooms were clean, and comfortable beds!! Had a very enjoyable stay!! Thank you Marriott staff!!"

Reviewed on May 14, 2025

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (5,216 reviews)
"Excellent location"

Reviewed on May 14, 2025

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,580 reviews)
"Elevator not working, kitchen breakfast staff in a hurry to clean and not nice or helpful at all"

Reviewed on May 16, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,363 reviews)
"This is a very old hotel and it shows. The hotel is immaculate and the staff is wonderful. The room though, while clean, is very small and when I opened the blinds to look and see my view I saw a naked man across the courtyard with his window open. A great hotel if you are there just to sleep in ..."

Reviewed on May 15, 2025

Crockett Hotel
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,520 reviews)
"Staff was great super quiet and rooms were so nice"

Reviewed on May 14, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,374 reviews)
"As many have already stated this location is close to almost everything that we wanted to see in San Antonio. We went there when the weather was reasonable and with the exception of the food offered by the hotel (which was free so no complaints at all), everything else about our stay there was just ..."

Reviewed on May 15, 2025

Drury Plaza Hotel San Antonio Riverwalk
Spark By Hilton San Antonio Northwest near Six Flags
Spark By Hilton San Antonio Northwest near Six Flags
3 out of 5
6755 North Loop 1604 West, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. Popular attractions ...
8/10 Very Good! (1,112 reviews)
After six (6) trips
"It is a Spartan experience meaning that you must pick up a cup in the kitchen area because NONE are available in the room. Breakfast is not classical eggs and sausage. It is dry cereal, bagels, muffin, yogurt, and coffee. Still, the beds are comfortable, the rooms are clean, and most importantly ..."

Reviewed on May 16, 2025

Spark By Hilton San Antonio Northwest near Six Flags
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
8.8/10 Excellent! (3,284 reviews)
"All food"

Reviewed on May 17, 2025

Menger Hotel
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (3,058 reviews)
"Love this property"

Reviewed on May 14, 2025

Hotel Contessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.