Hotels Near
Serra Mesa

Check Last Minute Serra Mesa Hotel Deals

Tonight Jun 2 - Jun 3This weekend Jun 2 - Jun 4

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured Serra Mesa Hotels

Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA, 92110
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly aparthotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and ...
7/10 Good! (1,223 reviews)
Pleasant stay!
"We enjoyed the comfort and friendly reception & service."

Reviewed on May 29, 2023

Wyndham Garden San Diego Near SeaWorld
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA, 92101
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 6 restaurants. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (4,184 reviews)
"Beautiful, great walkability, amazing amenities. I'd stay here again!"

Reviewed on May 31, 2023

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA, 92101
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the clean rooms and the overall ...
8/10 Very Good! (6,555 reviews)
"We were there for a special occasion. When we got to our room, there was a Cheese, fruit plate waiting for us along with a card. Thought that was a very nice touch. Rooms clean and comfortable. Check in easy and very pleasant. Will stay here again on next trip to San Diego."

Reviewed on May 31, 2023

Wyndham San Diego Bayside
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (992 reviews)
"The front desk (Anna) and staff made our trip exceptionally easy. Everyone was eager to help us and make sure our stay was flawless."

Reviewed on May 29, 2023

San Diego Mission Bay Resort
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach aparthotel in San Diego. Enjoy free WiFi, 5 outdoor pools, and 3 restaurants. Our guests praise the restaurant and the helpful staff ...
8.4/10 Very Good! (2,777 reviews)
"The best resort in San Diego, very hospitable, generous, outstanding room service, 5 outdoor pools w hot tubs terrific, tennis courts, fire pets, everything u can ask for"

Reviewed on May 31, 2023

Paradise Point Resort & Spa
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA, 92109
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and a marina. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,598 reviews)
"Such an amazing place to stay… all of the staff is beyond helpful and friendly.. perfect area to get around mission beach easily… and if you do sea world they have a shuttle.. saves your drive and parking fees.."

Reviewed on May 29, 2023

The Dana on Mission Bay
Loews Coronado Bay Resort
Loews Coronado Bay Resort
4 out of 5
4000 Coronado Bay Rd, Coronado, CA, 92118
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a marina. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (1,007 reviews)
"Great place to stay and ppl there were great"

Reviewed on May 31, 2023

Loews Coronado Bay Resort
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
4 out of 5
1380 Harbor Island Dr, San Diego, CA, 92101
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 6 restaurants. Our guests praise the restaurant and the ...
7.6/10 Good! (2,395 reviews)
Nice hotel
"Great check in with Matthew late at night Room very nice and close to airport."

Reviewed on May 31, 2023

Sheraton San Diego Hotel and Marina
The Atwood
The Atwood
3 out of 5
1201 Hotel Circle South, Mission Valley, San Diego, CA, 92108
Fully refundableReserve now, pay when you stay
Stay at this 3-star golf aparthotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (2,275 reviews)
"The staff was very friendly."

Reviewed on May 28, 2023

The Atwood
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA, 92101
Fully refundableReserve now, pay when you stay
Stay at this 4-star aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the clean rooms in our ...
8.4/10 Very Good! (2,351 reviews)
"Nice room."

Reviewed on May 31, 2023

Hard Rock Hotel San Diego
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA, 92101
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa aparthotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (2,262 reviews)
"We had a very pleasant stay at the Marriot Marquis San Diego. The resort was beautiful and plenty of activities. The room we got was great. Walking distance or short Uber away from Gas Light district. we recommend this hotel. Ask for the Bay view and North tower has balconies."

Reviewed on May 31, 2023

Marriott Marquis San Diego Marina
Best Western Plus Island Palms Hotel & Marina
Best Western Plus Island Palms Hotel & Marina
3 out of 5
2051 Shelter Island Dr, San Diego, CA, 92106
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and a marina. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,491 reviews)
"Nice location, convenient, clean"

Reviewed on May 29, 2023

Best Western Plus Island Palms Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Serra Mesa

San Diego is a city that has a lot going on, but you have your sights set on Serra Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Serra Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Serra Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Serra Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Serra Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Serra Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Serra Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $119
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Serra Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.