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Featured South Carolina Midlands Family Hotels
![Home2 Suites by Hilton Florence, SC](https://images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/971cc1b8_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd, Florence, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
![Country Inn & Suites by Radisson, Aiken, SC](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353807/8d8e8f43_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Country Inn & Suites by Radisson, Aiken, SC
3270 Whiskey Rd, Aiken, SC
Fully refundable
Book a stay at this business-friendly hotel in Aiken. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/c2bace01_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Hyatt Place Columbia/Downtown/The Vista
819 Gervais Street, Columbia, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
![Country Inn & Suites by Radisson, Columbia, SC](https://images.trvl-media.com/lodging/1000000/210000/202900/202867/bf1040e9_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Country Inn & Suites by Radisson, Columbia, SC
220 E Exchange Blvd, Columbia, SC
Fully refundable
Book a stay at this spa hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
![Baymont Inn & Suites Florence by Wyndham](https://images.trvl-media.com/lodging/1000000/10000/500/460/7cc7addd_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont Inn & Suites Florence by Wyndham
1826 W Lucas Street, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Beaver Creek Golf Club and Palmetto ...
![Hampton Inn & Suites Columbia/Southeast-Ft. Jackson](https://images.trvl-media.com/lodging/6000000/5090000/5087800/5087799/66f4a5f4_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Hampton Inn & Suites Columbia/Southeast-Ft. Jackson
201 East Exchange Boulevard, Columbia, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the breakfast ...
![SpringHill Suites by Marriott Columbia Downtown/The Vista](https://images.trvl-media.com/lodging/3000000/2570000/2564900/2564892/15a124c8_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
SpringHill Suites by Marriott Columbia Downtown/The Vista
511 Lady Street, Columbia, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
![Hyatt Place Columbia/Harbison](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/d546b726_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Hyatt Place Columbia/Harbison
1130 Kinley Road, Irmo, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Irmo. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff ...
![Homewood Suites by Hilton Columbia](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077175/e0188fb0_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Homewood Suites by Hilton Columbia
230 Greystone Blvd, Columbia, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
![Baymont by Wyndham Columbia Northwest](https://images.trvl-media.com/lodging/1000000/20000/17600/17541/59eb211f_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont by Wyndham Columbia Northwest
347 Zimalcrest Drive, Columbia, SC
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Riverbanks Botanical Garden and ...
![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/26a36f59_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont by Wyndham Columbia Fort Jackson
240 E Exchange Blvd, Columbia, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
![Country Inn & Suites by Radisson, Florence, SC](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/22516d95_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Country Inn & Suites by Radisson, Florence, SC
1739 Mandeville Rd, Florence, SC
Fully refundable
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in South Carolina Midlands
![Aloft Columbia Downtown](https://images.trvl-media.com/lodging/17000000/16710000/16706100/16706011/03879dd3_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Aloft Columbia Downtown
823 Lady St, Columbia, SC
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/26a36f59_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont by Wyndham Columbia Fort Jackson
240 E Exchange Blvd, Columbia, SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
![Baymont Inn & Suites Florence by Wyndham](https://images.trvl-media.com/lodging/1000000/10000/500/460/7cc7addd_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont Inn & Suites Florence by Wyndham
1826 W Lucas Street, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Beaver Creek Golf Club and Palmetto ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in South Carolina Midlands
- Hotels with a Pool in South Carolina Midlands
- Pet-friendly Hotels in South Carolina Midlands
- Historic Hotels in South Carolina Midlands
- Luxury Hotels in South Carolina Midlands
- Hotels with Hot Tubs in South Carolina Midlands
- Apartment Hotel in South Carolina Midlands
- Hotels with an Indoor Pool in South Carolina Midlands
- Resorts & Hotels with Spas in South Carolina Midlands
- Hotel Wedding Venues in South Carolina Midlands
South Carolina Midlands Neighborhoods
Top Points of Interests in South Carolina Midlands
- Hotels near Fort Jackson
- Hotels near Carowinds Theme Park
- Hotels near University of South Carolina
- Hotels near Williams Brice Stadium
- Hotels near Rock Hill Sports & Event Center
- Hotels near Riverbanks Zoo and Garden
- Hotels near Lake Marion
- Hotels near Colonial Life Arena
- Hotels near Florence Civic Center
- Hotels near Columbia Metropolitan Convention Center
- Hotels near Shaw Air Force Base
- Hotels near Congaree National Park
- Hotels near Darlington Raceway
- Hotels near Francis Marion University
- Hotels near Village at Sandhill Mall
- Hotels near Magnolia Mall
- Hotels near Township Auditorium
- Hotels near Rock Hill Galleria
- Hotels near South Carolina State Fairgrounds
- Hotels near Mcleod Regional Medical Center
Cities near South Carolina Midlands
- Columbia Hotels (10.91 mi)
- Augusta Hotels (75.58 mi)
- Concord Hotels (93.79 mi)
- Florence Hotels (63.1 mi)
- Rock Hill Hotels (59.76 mi)
- Summerville Hotels (82.66 mi)
- Spartanburg Hotels (86 mi)
- Anderson Hotels (106.34 mi)
- Aiken Hotels (60.64 mi)
- Georgetown Hotels (101.94 mi)
- Fort Mill Hotels (64.88 mi)
- Conway Hotels (105.13 mi)
- Ninety Six Hotels (66.84 mi)
- Santee Hotels (45.91 mi)
- Coastal South Carolina Hotels (85.41 mi)
- Huntersville Hotels (92.56 mi)
- Walterboro Hotels (81.4 mi)
- Gastonia Hotels (84.31 mi)
- Orangeburg Hotels (39.94 mi)
- Lexington Hotels (22.3 mi)
Car Rentals Near South Carolina Midlands
- Car rentals in Columbia
- Car rentals in Augusta
- Car rentals in Concord
- Car rentals in Florence
- Car rentals in Rock Hill
- Car rentals in Summerville
- Car rentals in Spartanburg
- Car rentals in Anderson
- Car rentals in Aiken
- Car rentals in Georgetown
- Car rentals in Fort Mill
- Car rentals in Conway
- Car rentals in Ninety Six
- Car rentals in Santee
- Car rentals in Coastal South Carolina
- Car rentals in Huntersville
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in South Carolina Midlands
- Hyatt Place Florence Downtown
- Quality Inn & Suites Florence Civic Center
- Hilton Garden Inn Columbia/Harbison
- Howard Johnson by Wyndham Florence
- Holiday Inn Columbia - Downtown, an IHG Hotel
- Sheraton Columbia Downtown Hotel
- Hyatt Place Columbia/Downtown/The Vista
- Baymont by Wyndham Columbia Northwest
- Hampton Inn & Suites Columbia Killian Road
- Hyatt Place Columbia/Harbison