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Hotels in South Carolina Midlands

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Choose from 3275 South Carolina Midlands Hotel Deals

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr Columbia SC
  • 34 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (2,048 reviews)
This was one of the best quietest hotel stays i have had. The front deck staff was so nice and helpful. We will definitely be staying at this hotel again

Reviewed on May 12, 2026

Hilton Garden Inn Columbia/Harbison
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
1901 Rockland Rd Columbia SC
  • 25 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,072 reviews)
The rooms are clean. The staff was friendly and the parking was convenient.

Reviewed on May 12, 2026

Sleep Inn Columbia
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 3 hours drive from Fort Jackson
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,648 reviews)
Continently located right off the highway with ample safe parking. Clean rooms, towels and bathrooms. Could use some updating/ maintenance… our tub and sink took a long time to drain, the sink faucet wasn’t attached to the sink, and multiple pieces of the baseboard trim were loose or unattached ...

Reviewed on May 9, 2026

Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 3 hours drive from Fort Jackson
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (137 reviews)
The staff was very friendly and cared about my needs!

Reviewed on May 10, 2026

Quality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 3 hours drive from Fort Jackson
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,278 reviews)
Chambre très correcte pour y passer une nuit. Étages réservés pour des chambres sans animaux acceptés. Bravo ! Un peu plus d’entretien pour tenir les chambres à jour. Penser à ajouter une chaise supplémentaire dans les chambres… 2 adultes et une seule chaise c’est absolument insuffisant.

Reviewed on May 11, 2026

Park Inn by Radisson Florence, SC
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
7333 Garners Ferry Rd Columbia SC
  • 9 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Millwood Plantation Ruins and ...
8/10 Very Good! (1,019 reviews)
Nice

Reviewed on May 12, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street Columbia SC
  • 15 min drive from Fort Jackson
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Riverbanks Zoo and Garden and EdVenture ...
9.4/10 Exceptional! (645 reviews)
The property did not disappoint. Actually, I was pleasantly surprised that there was a full breakfast and bar. All of the staff were very hospitable and met all of my needs. The soap, shampoo and body lotion are a beautiful touch as I forgot my some toiletries. Highly recommended. They provided the ...

Reviewed on May 12, 2026

Tru By Hilton Columbia Downtown
Courtyard by Marriott Columbia Downtown at USC

Courtyard by Marriott Columbia Downtown at USC

3 out of 5
630 Assembly St Columbia SC
  • 13 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,021 reviews)
Dining not good. Pool really not good. Staff were fine.

Reviewed on May 12, 2026

Courtyard by Marriott Columbia Downtown at USC
Hyatt Place Columbia/Downtown/The Vista

Hyatt Place Columbia/Downtown/The Vista

3 out of 5
819 Gervais Street Columbia SC
  • 14 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,007 reviews)
Great location and comfort for my stay.

Reviewed on May 5, 2026

Hyatt Place Columbia/Downtown/The Vista
Country Inn & Suites by Radisson, Columbia, SC

Country Inn & Suites by Radisson, Columbia, SC

2.5 out of 5
220 E Exchange Blvd Columbia SC
  • 9 min drive from Fort Jackson
Book a stay at this spa hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.8/10 Good! (1,105 reviews)
Some of the fixtures in the room are dated and need repair, but the room itself was clean .

Reviewed on May 11, 2026

Country Inn & Suites by Radisson, Columbia, SC
Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

4 out of 5
1619 Pendleton Street Columbia SC
  • 12 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,015 reviews)
Great coffee and front desk service!

Reviewed on May 5, 2026

Graduate by Hilton Columbia SC
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr Columbia SC
  • 9 min drive from Fort Jackson
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,438 reviews)
Never will stay here. Terrible experience.

Reviewed on May 11, 2026

Wyndham Garden Columbia/Ft. Jackson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South Carolina Midlands

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in South Carolina Midlands.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South Carolina Midlands’s 3,275 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $75. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South Carolina Midlands hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South Carolina Midlands. No matter your reason for visiting South Carolina Midlands, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South Carolina Midlands hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South Carolina Midlands for as low as $75.

How many hotels are there in South Carolina Midlands?

With over 3,275 hotels in South Carolina Midlands, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $75.

How to find cheap car rentals in South Carolina Midlands?

Finding a cheap car rental deal in South Carolina Midlands is as easy as scoring cheap hotels in South Carolina Midlands. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.