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4 Star Hotels in Florida Keys

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Featured 4 Star Florida Keys Hotels

Hawks Cay Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Duval Street
The price is $314 per night from Sep 9 to Sep 10
$314
includes taxes & fees
Sep 9 - Sep 10
Book a stay at this beach hotel in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Hawks Cay Resort
Baker's Cay Resort Key Largo, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 4 hours drive from Duval Street
The price is $342 per night from Sep 16 to Sep 17
$342
includes taxes & fees
Sep 16 - Sep 17
Book a stay at this beach hotel in Key Largo. Enjoy 2 outdoor pools, 2 restaurants, and a private beach. Our guests praise the helpful staff and the clean rooms ...
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Amara Cay Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 3 hours drive from Duval Street
The price is $248 per night from Sep 15 to Sep 16
$248
includes taxes & fees
Sep 15 - Sep 16
Stay at this 4-star beach resort in Islamorada. Enjoy free parking, 2 restaurants, and a private beach. Our guests praise the pool and the bar in our reviews. ...
Amara Cay Resort
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Playa Largo Resort & Spa, Autograph Collection
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 4 hours drive from Duval Street
The price is $266 per night from Sep 12 to Sep 13
$266
includes taxes & fees
Sep 12 - Sep 13
Stay at this 4.5-star luxury resort in Key Largo. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Playa Largo Resort & Spa, Autograph Collection
Islander Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 3 hours drive from Duval Street
The price is $257 per night from Sep 15 to Sep 16
$257
includes taxes & fees
Sep 15 - Sep 16
Stay at this 4-star beach hotel in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
Islander Resort
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Duval Street
The price is $199 per night from Sep 29 to Sep 30
$199
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star beach hotel in Marathon. Enjoy free WiFi, 4 outdoor pools, and 4 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
La Siesta Resort & Villas
4 out of 5
  • 3 hours drive from Duval Street
The price is $231 per night from Sep 15 to Sep 16
$231
includes taxes & fees
Sep 15 - Sep 16
Stay at this 4-star beach resort in Islamorada. Enjoy a private beach, a marina, and breakfast (surcharge). Our guests praise the helpful staff and the spacious ...
La Siesta Resort & Villas
Tranquility Bay Beachfront Hotel and Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Duval Street
The price is $254 per night from Sep 18 to Sep 19
$254
includes taxes & fees
Sep 18 - Sep 19
Stay at this 4-star beach hotel in Marathon. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
Tranquility Bay Beachfront Hotel and Resort
Villas At Hawks Cay Resort
4 out of 5
  • 2 hours drive from Duval Street
Stay at this 4-star beach resort in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Popular attractions Little Conch Key and Walkers Island ...
Villas At Hawks Cay Resort
The Islands of Islamorada
4 out of 5
  • 3 hours drive from Duval Street
Stay at this 4-star beach villa in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Popular attractions History of Diving Museum and Islamorada ...
The Islands of Islamorada
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-Star Hotels in Florida Keys

When you want to live the good life, but not blow all your savings, book yourself a 4-star hotel in Florida Keys for your next trip. You'll score all the amenities you can think of (and then some) at a rate within your means. Sprawl out on high thread-count sheets, work on your tan by the picturesque pool, expand your palate at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your beck and call at Florida Keys 4-star hotels.

Reach for the 4 stars

So what's the star rating about anyway? Good question. Star rating doesn't have much to do with the price, and much more to do with the amenities. 4-star hotels in Florida Keys, United States of America, as well as everywhere else, usually have a bunch of amazing extras that make you say "Oh," "Wow," and "YES!" You can expect amenities like sophisticated gadgets, concierge services, ritzy bed linens, and restaurants that make eating in a foodie's dream.

Written in the stars

Yeah, Florida Keys has as many hot spots, inviting lounges, and bumping music venues as there are stars lighting up the sky. But you gotta have the money to check them all off. That's why we give you the opportunity to save up to 60% with the Hotwire Hot Rate. You can snag Florida Keys 4-star hotels and still have enough leftover cash to paint the town red. Hotwire has a ton of excellent options for your stay, so we thought we'd to make it a bit easier to pick the perfect hotel. Filter the best 4-star hotels in Florida Keys by:

  • Hotwire Hot Rate: Looking for the best deals on the net? Let us choose the hotel. We'll tell you which hotel after you book, and the savings and accommodations will be spectacular.
  • Price: Who wants to pay full price? Anybody? You can get a cheap 4-star hotel in Florida Keys starting at $199 per night.
  • Amenities: What makes up your vacation wish list? 24-hour room service? Heated pool? Full-service spa? Find the hotel of your dreams.

You deserve all the best. Perks galore and the sweetest spot to press reset in Florida Keys without spending your entire vacation budget. When you reserve a Hotwire Hot Rate, you get that stellar Florida Keys 4-star hotel and have cash left to check off everything on your to-do list on your superstar vacay. We have 8,077 Florida Keys hotels waiting for you, but the best rooms go quickly so book your stay today.