Search for Cheap Deals on
Spa Resort Hotels in Panama City

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured Panama City Resorts & Hotels with Spas

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 out of 5
56 y 57 East Street, Obarrio, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff in our reviews. Popular ...
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5 out of 5
Santa Maria Boulevard, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff ...
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Marriott Panama Hotel
Marriott Panama Hotel
4 out of 5
Roosevelt Ave., Allbrook Mall, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the restaurant and the helpful ...
Marriott Panama Hotel
Bristol Panama, a Registry Collection Hotel
Bristol Panama, a Registry Collection Hotel
5 out of 5
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the breakfast and the restaurant ...
Bristol Panama, a Registry Collection Hotel
W Panama
W Panama
5 out of 5
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 spa tubs, and 2 bars/lounges. Our guests praise the breakfast and the pool in our reviews. ...
W Panama
Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama City
5 out of 5
Calle Primera Oeste, San Felipe, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our ...
Sofitel Legend Casco Viejo, Panama City
Sheraton Grand Panama
Sheraton Grand Panama
4.5 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Sheraton Grand Panama
Hilton Panama
Hilton Panama
5 out of 5
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the pool and the helpful ...
Hilton Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
JW Marriott Panama
Aloft Panama
Aloft Panama
3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Popular attractions Albrook Shopping Mall and Multiplaza ...
Aloft Panama
Hotel La Compania, in the Unbound Collection by Hyatt
Hotel La Compania, in the Unbound Collection by Hyatt
4.5 out of 5
Avenida A, Esquina Calle 8, Casco Antiguo, Panama City, Panama
Fully refundable
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property ...
Hotel La Compania, in the Unbound Collection by Hyatt
The Westin Panama
The Westin Panama
4 out of 5
La Rotonda Street, Costa del Este, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Popular attractions Albrook Shopping ...
The Westin Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.