Search for Cheap Deals on
4 Star Hotels in Mission Valley

Check Last Minute Mission Valley Hotel Deals

Tonight Jan 18 - Jan 19Next weekend Jan 24 - Jan 26

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Mission Valley Hotels

Manchester Grand Hyatt San Diego
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from Hotel Circle
The price is $266 per night from Jan 19 to Jan 20
$266
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Manchester Grand Hyatt San Diego
San Diego Marriott Gaslamp Quarter
4 out of 5
  • 9 min drive from Hotel Circle
The price is $181 per night from Jan 19 to Jan 20
$181
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly hotel in San Diego. Enjoy 2 bars/lounges, a nightclub, and breakfast (surcharge). Our guests praise the bar and the helpful ...
San Diego Marriott Gaslamp Quarter
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min walk from Hotel Circle
The price is $234 per night from Jan 19 to Jan 20
$234
includes taxes & fees
Jan 19 - Jan 20
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Hyatt Regency Mission Bay Spa and Marina
Save an average of 15% on thousands of hotels when you're signed in
Sheraton San Diego Resort
4 out of 5
  • 6 min drive from Hotel Circle
The price is $203 per night from Jan 24 to Jan 25
$203
includes taxes & fees
Jan 24 - Jan 25
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
Sheraton San Diego Resort
Omni San Diego Hotel
4 out of 5
  • 9 min drive from Hotel Circle
The price is $232 per night from Feb 7 to Feb 8
$232
includes taxes & fees
Feb 7 - Feb 8
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Omni San Diego Hotel
Loews Coronado Bay Resort
4 out of 5
  • 22 min drive from Hotel Circle
The price is $266 per night from Jan 26 to Jan 27
$266
includes taxes & fees
Jan 26 - Jan 27
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Loews Coronado Bay Resort
Hotel Indigo San Diego-Gaslamp Quarter, an IHG Hotel
4 out of 5
  • 8 min drive from Hotel Circle
The price is $249 per night from Jan 19 to Jan 20
$249
includes taxes & fees
Jan 19 - Jan 20
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hotel Indigo San Diego-Gaslamp Quarter, an IHG Hotel
Lafayette Hotel & Club
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from Hotel Circle
The price is $232 per night from Jan 20 to Jan 21
$232
includes taxes & fees
Jan 20 - Jan 21
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
Hilton San Diego Bayfront
4 out of 5
  • 9 min drive from Hotel Circle
The price is $206 per night from Feb 7 to Feb 8
$206
includes taxes & fees
Feb 7 - Feb 8
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
Hilton San Diego Bayfront
Wyndham San Diego Bayside
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from Hotel Circle
The price is $181 per night from Jan 31 to Feb 1
$181
includes taxes & fees
Jan 31 - Feb 1
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Alma San Diego Downtown, a Tribute Portfolio Hotel
4 out of 5
  • 8 min drive from Hotel Circle
The price is $197 per night from Jan 19 to Jan 20
$197
includes taxes & fees
Jan 19 - Jan 20
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Alma San Diego Downtown, a Tribute Portfolio Hotel
Marriott Marquis San Diego Marina
4 out of 5
  • 9 min drive from Hotel Circle
The price is $260 per night from Jan 19 to Jan 20
$260
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff in ...
Marriott Marquis San Diego Marina
Don't see what you're looking for?
See all available properties in Mission Valley
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-Star Hotels in Mission Valley

If you're ready to live the good life, but not break the bank, it's time to look into a 4-star hotel in Mission Valley for your next vacation. You'll get all the perks you've been dreaming of (and then some) at a rate within your means. Sprawl out on high thread-count sheets, work on your tan by the scenic pool, indulge at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your beck and call at Mission Valley 4-star hotels.

The 4 stars are aligned

So what's the star rating all about? Here's how it works: A hotel's star rating doesn't have much to do with the price of your room, and more to do with the glowing amenities. 4-star hotels in Mission Valley, San Diego, and everywhere else, often have all those fancy extras that make you go "Oh," "Wow," and "YES!" Think amenities like opulent bedding, sophisticated electronics, personalized concierge service, and cafes that make dining in a meal for the books.

Written in the stars

You know there are as many cool spots, divey lounges, and memory-making music venues as there are stars in the sky. But you'll need the funds to check them all off. That's why we give you the chance to enjoy some modest savings with the Hotwire Hot Rate. You can book Mission Valley 4-star hotels and still have enough spending money to paint the town red. We have so many awesome options for your stay that we thought we'd to make it a bit easier to find the right hotel. Filter the best 4-star hotels in Mission Valley by:

  • Hotwire Hot Rate: With so many amazing hotels to choose from, we'll grab you a sweet deal on a room by telling you your hotel name after you book. Wishing on 4 stars? Not necessary.
  • Price: With prices as low as $181, we know you'll find a cheap 4-star hotel in Mission Valley that won't break the bank.
  • Amenities: What makes up your vacation wish list? Heated pool? Full-service spa? 24-hour room service? Find a hotel that'll send you over the moon.

You deserve the finer things. Perks galore and the sweetest spot to recharge in Mission Valley without blowing all of your fun money. When you book a Hotwire Hot Rate, you score that stellar Mission Valley 4-star hotel and have cash left to do everything you want on your superstar vacay. Hotwire has 8,386 Mission Valley hotels waiting for you, but the most popular rooms aren't available long so book your room today.