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4 Star Hotels in Mission Valley

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Featured 4 Star Mission Valley Hotels

Manchester Grand Hyatt San Diego
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from Hotel Circle
The price is $232 per night from Dec 19 to Dec 20
$232
includes taxes & fees
Dec 19 - Dec 20
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Manchester Grand Hyatt San Diego
San Diego Marriott La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 19 min drive from Hotel Circle
The price is $162 per night from Jan 10 to Jan 11
$162
includes taxes & fees
Jan 10 - Jan 11, 2025
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
San Diego Marriott La Jolla
Paradise Point Resort & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 28 min walk from Hotel Circle
The price is $251 per night from Dec 19 to Dec 20
$251
includes taxes & fees
Dec 19 - Dec 20
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
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Sheraton San Diego Hotel and Marina
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from Hotel Circle
The price is $163 per night from Dec 24 to Dec 25
$163
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
Sheraton San Diego Hotel and Marina
Wyndham San Diego Bayside
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from Hotel Circle
The price is $152 per night from Dec 24 to Dec 25
$152
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Hotel Indigo San Diego-Gaslamp Quarter, an IHG Hotel
4 out of 5
Fully refundable
  • 8 min drive from Hotel Circle
The price is $172 per night from Dec 22 to Dec 23
$172
includes taxes & fees
Dec 22 - Dec 23
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hotel Indigo San Diego-Gaslamp Quarter, an IHG Hotel
Lafayette Hotel & Club
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from Hotel Circle
The price is $226 per night from Dec 19 to Dec 20
$226
includes taxes & fees
Dec 19 - Dec 20
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
Hilton San Diego Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min walk from Hotel Circle
The price is $141 per night from Dec 24 to Dec 25
$141
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
Sheraton Mission Valley San Diego Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 10 min walk from Hotel Circle
The price is $141 per night from Dec 23 to Dec 24
$141
includes taxes & fees
Dec 23 - Dec 24
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Sheraton Mission Valley San Diego Hotel
Omni San Diego Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from Hotel Circle
The price is $206 per night from Dec 19 to Dec 20
$206
includes taxes & fees
Dec 19 - Dec 20
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Omni San Diego Hotel
Marriott Marquis San Diego Marina
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from Hotel Circle
The price is $217 per night from Dec 24 to Dec 25
$217
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff in ...
Marriott Marquis San Diego Marina
Embassy Suites by Hilton San Diego Bay Downtown
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from Hotel Circle
The price is $241 per night from Jan 2 to Jan 3
$241
includes taxes & fees
Jan 2 - Jan 3, 2025
Book a stay at this family-friendly hotel in San Diego. Enjoy room service, a fitness center, and WiFi (surcharge). Our guests praise the breakfast and the helpful ...
Embassy Suites by Hilton San Diego Bay Downtown
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4-Star Hotels in Mission Valley

If you're ready to live the good life, but not break the bank, it's time to look into a 4-star hotel in Mission Valley for your next vacation. You'll get all the perks you've been dreaming of (and then some) at a rate within your means. Sprawl out on high thread-count sheets, work on your tan by the scenic pool, indulge at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your beck and call at Mission Valley 4-star hotels.

The 4 stars are aligned

So what's the star rating all about? Here's how it works: A hotel's star rating doesn't have much to do with the price of your room, and more to do with the glowing amenities. 4-star hotels in Mission Valley, San Diego, and everywhere else, often have all those fancy extras that make you go "Oh," "Wow," and "YES!" Think amenities like opulent bedding, sophisticated electronics, personalized concierge service, and cafes that make dining in a meal for the books.

Written in the stars

You know there are as many cool spots, divey lounges, and memory-making music venues as there are stars in the sky. But you'll need the funds to check them all off. That's why we give you the chance to enjoy some modest savings with the Hotwire Hot Rate. You can book Mission Valley 4-star hotels and still have enough spending money to paint the town red. We have so many awesome options for your stay that we thought we'd to make it a bit easier to find the right hotel. Filter the best 4-star hotels in Mission Valley by:

  • Hotwire Hot Rate: With so many amazing hotels to choose from, we'll grab you a sweet deal on a room by telling you your hotel name after you book. Wishing on 4 stars? Not necessary.
  • Price: With prices as low as $141, we know you'll find a cheap 4-star hotel in Mission Valley that won't break the bank.
  • Amenities: What makes up your vacation wish list? Heated pool? Full-service spa? 24-hour room service? Find a hotel that'll send you over the moon.

You deserve the finer things. Perks galore and the sweetest spot to recharge in Mission Valley without blowing all of your fun money. When you book a Hotwire Hot Rate, you score that stellar Mission Valley 4-star hotel and have cash left to do everything you want on your superstar vacay. Hotwire has 8,296 Mission Valley hotels waiting for you, but the most popular rooms aren't available long so book your room today.