Search for Cheap Deals on
4 Star Hotels in Mission Valley

Check Last Minute Mission Valley Hotel Deals

Tonight May 2 - May 3This weekend May 2 - May 4

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Mission Valley Hotels

San Diego Marriott La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 19 min drive from Hotel Circle
The price is $192 per night from May 26 to May 27
$192
includes taxes & fees
May 26 - May 27
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
San Diego Marriott La Jolla
Wyndham San Diego Bayside
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from Hotel Circle
The price is $176 per night from May 11 to May 12
$176
includes taxes & fees
May 11 - May 12
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Loews Coronado Bay Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 22 min drive from Hotel Circle
The price is $266 per night from May 26 to May 27
$266
includes taxes & fees
May 26 - May 27
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Loews Coronado Bay Resort
Save an average of 15% on thousands of hotels when you're signed in
San Diego Mission Bay Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min walk from Hotel Circle
The price is $285 per night from May 11 to May 12
$285
includes taxes & fees
May 11 - May 12
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
San Diego Mission Bay Resort
Legacy Resort Hotel & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 min walk from Hotel Circle
The price is $194 per night from May 11 to May 12
$194
includes taxes & fees
May 11 - May 12
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Legacy Resort Hotel & Spa
Sheraton San Diego Resort
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from Hotel Circle
The price is $236 per night from May 12 to May 13
$236
includes taxes & fees
May 12 - May 13
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 5 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
Sheraton San Diego Resort
Hard Rock Hotel San Diego
4 out of 5
  • 9 min drive from Hotel Circle
The price is $291 per night from May 7 to May 8
$291
includes taxes & fees
May 7 - May 8
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
Hard Rock Hotel San Diego
Hilton San Diego Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min walk from Hotel Circle
The price is $144 per night from May 11 to May 12
$144
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
Manchester Grand Hyatt San Diego
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from Hotel Circle
The price is $234 per night from May 23 to May 24
$234
includes taxes & fees
May 23 - May 24
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Manchester Grand Hyatt San Diego
Lafayette Hotel & Club
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from Hotel Circle
The price is $259 per night from May 6 to May 7
$259
includes taxes & fees
May 6 - May 7
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
The Little Italy Hotel Downtown San Diego
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from Hotel Circle
The price is $109 per night from May 11 to May 12
$109
includes taxes & fees
May 11 - May 12
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
The Little Italy Hotel Downtown San Diego
Omni San Diego Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from Hotel Circle
The price is $369 per night from May 23 to May 24
$369
includes taxes & fees
May 23 - May 24
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Omni San Diego Hotel
Don't see what you're looking for?
See all available properties in Mission Valley
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-Star Hotels in Mission Valley

If you're ready to live the good life, but not break the bank, it's time to look into a 4-star hotel in Mission Valley for your next vacation. You'll get all the perks you've been dreaming of (and then some) at a rate within your means. Sprawl out on high thread-count sheets, work on your tan by the scenic pool, indulge at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your beck and call at Mission Valley 4-star hotels.

The 4 stars are aligned

So what's the star rating all about? Here's how it works: A hotel's star rating doesn't have much to do with the price of your room, and more to do with the glowing amenities. 4-star hotels in Mission Valley, San Diego, and everywhere else, often have all those fancy extras that make you go "Oh," "Wow," and "YES!" Think amenities like opulent bedding, sophisticated electronics, personalized concierge service, and cafes that make dining in a meal for the books.

Written in the stars

You know there are as many cool spots, divey lounges, and memory-making music venues as there are stars in the sky. But you'll need the funds to check them all off. That's why we give you the chance to enjoy some modest savings with the Hotwire Hot Rate. You can book Mission Valley 4-star hotels and still have enough spending money to paint the town red. We have so many awesome options for your stay that we thought we'd to make it a bit easier to find the right hotel. Filter the best 4-star hotels in Mission Valley by:

  • Hotwire Hot Rate: With so many amazing hotels to choose from, we'll grab you a sweet deal on a room by telling you your hotel name after you book. Wishing on 4 stars? Not necessary.
  • Price: With prices as low as $109, we know you'll find a cheap 4-star hotel in Mission Valley that won't break the bank.
  • Amenities: What makes up your vacation wish list? Heated pool? Full-service spa? 24-hour room service? Find a hotel that'll send you over the moon.

You deserve the finer things. Perks galore and the sweetest spot to recharge in Mission Valley without blowing all of your fun money. When you book a Hotwire Hot Rate, you score that stellar Mission Valley 4-star hotel and have cash left to do everything you want on your superstar vacay. Hotwire has 8,627 Mission Valley hotels waiting for you, but the most popular rooms aren't available long so book your room today.