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Depew

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Depew Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 27 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$56 Roundtrip, found 1 day ago
$56
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, May 27 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Sat, May 30, priced at $56 found 1 day ago
Frontier Airlines
Wed, Jun 10 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$58 Roundtrip, found 1 day ago
$58
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jun 10 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Tue, Jun 16, priced at $58 found 1 day ago
Frontier Airlines
Sat, May 2 - Sat, May 9
MCO
Orlando Intl.
BUF
Buffalo Niagara Intl.
$126 Roundtrip, found 6 days ago
$126
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sat, May 2 from Orlando Intl. to Buffalo Niagara Intl., returning Sat, May 9, priced at $126 found 6 days ago
Delta
Tue, Jun 30 - Fri, Jul 10
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$139 Roundtrip, found 1 hour ago
$139
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Jun 30 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Fri, Jul 10, priced at $139 found 1 hour ago
JetBlue Airways
Thu, May 28 - Thu, May 28
JFK
John F. Kennedy Intl.
BUF
Buffalo Niagara Intl.
$152 Roundtrip, found 1 day ago
$152
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, May 28 from John F. Kennedy Intl. to Buffalo Niagara Intl., returning Thu, May 28, priced at $152 found 1 day ago
Frontier Airlines
Sat, May 16 - Tue, Jun 2
FLL
Fort Lauderdale - Hollywood Intl.
BUF
Buffalo Niagara Intl.
$164 Roundtrip, found 2 days ago
$164
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sat, May 16 from Fort Lauderdale - Hollywood Intl. to Buffalo Niagara Intl., returning Tue, Jun 2, priced at $164 found 2 days ago
Frontier Airlines
Sat, May 30 - Mon, Jun 1
EWR
Newark Liberty Intl. Airport
BUF
Buffalo Niagara Intl.
$180 Roundtrip, found 18 hours ago
$180
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sat, May 30 from Newark Liberty Intl. Airport to Buffalo Niagara Intl., returning Mon, Jun 1, priced at $180 found 18 hours ago
American Airlines
Tue, May 19 - Wed, May 27
JFK
John F. Kennedy Intl.
BUF
Buffalo Niagara Intl.
$181 Roundtrip, found 19 hours ago
$181
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, May 19 from John F. Kennedy Intl. to Buffalo Niagara Intl., returning Wed, May 27, priced at $181 found 19 hours ago
Frontier Airlines
Wed, May 13 - Sun, May 17
IAH
George Bush Intercontinental
BUF
Buffalo Niagara Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, May 13 from George Bush Intercontinental to Buffalo Niagara Intl., returning Sun, May 17, priced at $195 found 1 day ago
Frontier Airlines
Sun, May 10 - Tue, May 26
DFW
Dallas-Fort Worth Intl.
BUF
Buffalo Niagara Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, May 10 from Dallas-Fort Worth Intl. to Buffalo Niagara Intl., returning Tue, May 26, priced at $195 found 1 day ago
Frontier Airlines
Thu, Apr 30 - Sat, May 16
ORD
O'Hare Intl.
BUF
Buffalo Niagara Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Apr 30 from O'Hare Intl. to Buffalo Niagara Intl., returning Sat, May 16, priced at $195 found 1 day ago
Frontier Airlines
Wed, May 13 - Tue, May 19
LAS
Harry Reid Intl.
BUF
Buffalo Niagara Intl.
$216 Roundtrip, found 2 hours ago
$216
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, May 13 from Harry Reid Intl. to Buffalo Niagara Intl., returning Tue, May 19, priced at $216 found 2 hours ago
United
Thu, May 28 - Tue, Jun 2
EWR
Newark Liberty Intl. Airport
BUF
Buffalo Niagara Intl.
$227 Roundtrip, found 1 day ago
$227
Roundtrip
found 1 day ago
Select United flight, departing Thu, May 28 from Newark Liberty Intl. Airport to Buffalo Niagara Intl., returning Tue, Jun 2, priced at $227 found 1 day ago
Delta
Tue, Aug 25 - Mon, Sep 7
PVD
T.F. Green
BUF
Buffalo Niagara Intl.
$248 Roundtrip, found 18 hours ago
$248
Roundtrip
found 18 hours ago
Select Delta flight, departing Tue, Aug 25 from T.F. Green to Buffalo Niagara Intl., returning Mon, Sep 7, priced at $248 found 18 hours ago
Delta
Fri, May 29 - Tue, Jun 2
DAL
Love Field
BUF
Buffalo Niagara Intl.
$405 Roundtrip, found 2 days ago
$405
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, May 29 from Love Field to Buffalo Niagara Intl., returning Tue, Jun 2, priced at $405 found 2 days ago
Alaska Airlines
Tue, May 12 - Fri, May 15
LAS
Harry Reid Intl.
BUF
Buffalo Niagara Intl.
$695 Roundtrip, found 22 hours ago
$695
Roundtrip
found 22 hours ago
Select Alaska Airlines flight, departing Tue, May 12 from Harry Reid Intl. to Buffalo Niagara Intl., returning Fri, May 15, priced at $695 found 22 hours ago

Cheap Flights to Depew

Fall in love at first flight with your vacation to Depew by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Depew on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Depew, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Depew

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Depew with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the BUF airport.

What is the cheapest month to fly to Depew?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Depew are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Depew?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Depew.

What airport is best to fly into Depew?

When you’re planning your trip to Depew, convenience is the name of the game. Luckily, Depew Buffalo Niagara Intl. Airport is nearby so you can deplane and get going on checking off everything on your Depew must-do list.

How much are flights to Depew?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Depew on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Depew?

The trick to saving a stack of cash on your flight to Depew? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Depew Flight Information
Destination airport
Buffalo Niagara Intl.
Destination airport IATA code
BUF
Roundtrip price
$56

Last Minute Hotel Deals in Depew

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
7.4/10 Good! (2,730 reviews)
The sound of water in the courtyard makes it very peaceful with all the plants and trees surrounding. Kids in the pool playing and having fun made it seem like a beach vacation. The staff greats you warmly and the restaurant on site has a decent menu for quick food and drinks. Nice place to stay ...

Reviewed on Apr 21, 2026

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M Hotel Buffalo
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (2,964 reviews)
Good

Reviewed on Apr 24, 2026

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Buffalo Airport Hotel
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Book a stay at this business-friendly hotel in Grand Island. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,771 reviews)
There was never anyone at the front desk. Disappointed that there was no hot tub. The first laundry had only one set of machines. And the laundry room was dirty.

Reviewed on Apr 24, 2026

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Holiday Inn Express Grand Island - Niagara Falls by IHG
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (2,060 reviews)
The staff were not very helpful. The front desk person didn't let us know that we had to put a parking pass in our car when he gave us our keys. We found out about the parking pass after we got to our room. So we had to go out to our car again! He was also not helpful when we told him the wifi was ...

Reviewed on Apr 25, 2026

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Sleep Inn & Suites Buffalo Airport
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (2,359 reviews)
The staff was great. Very helpful and friendly. I have stayed here in the past, but on this visit I could see the need for some major cleaning (staircase carpet}, refurbishment of aged furniture in the room, and replacement of water damaged ceiling tile throughout the facility. If my room is indicative ...

Reviewed on Apr 23, 2026

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Garden Place Hotel
Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown

3 out of 5
125 High St Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,789 reviews)
Everything was amazing. Staff helped alot

Reviewed on Apr 24, 2026

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Wyndham Garden Buffalo Downtown
La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

3 out of 5
6619 Transit Rd Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,506 reviews)
Room assigned at check-in had not been cleaned and bed was unmade. Desk staff apologized for inconvenience and immediately assigned substitute room after first inspecting it.

Reviewed on Apr 24, 2026

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La Quinta Inn by Wyndham Buffalo Airport
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,753 reviews)
I was assigned a handcap room and the shower head would not lock in the high position so had to use the wand to shower. Hard after a ling day of travel. The outlet for the coffee maker and the phone did not work. The remote control menu button did not work. The gym was nice and onsite amenities were ...

Reviewed on Apr 24, 2026

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Hyatt Regency Buffalo / Hotel and Conference Center
See all 882 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.