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Depew

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Depew Flights as Low as $88

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Oct 22 - Fri, Nov 6
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$88 Roundtrip, found 2 days ago
$88
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Oct 22 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Fri, Nov 6, priced at $88 found 2 days ago
Frontier Airlines
Mon, Oct 19 - Tue, Nov 3
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$98 Roundtrip, found 3 days ago
$98
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Oct 19 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Tue, Nov 3, priced at $98 found 3 days ago
Delta
Thu, Oct 22 - Fri, Nov 6
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$139 Roundtrip, found 2 days ago
$139
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Oct 22 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Fri, Nov 6, priced at $139 found 2 days ago
Frontier Airlines
Tue, Oct 20 - Tue, Nov 3
MCO
Orlando Intl.
BUF
Buffalo Niagara Intl.
$153 Roundtrip, found 1 day ago
$153
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Oct 20 from Orlando Intl. to Buffalo Niagara Intl., returning Tue, Nov 3, priced at $153 found 1 day ago
Southwest Airlines
Wed, Sep 2 - Sun, Sep 6
ATL
Hartsfield-Jackson Atlanta Intl.
BUF
Buffalo Niagara Intl.
$161 Roundtrip, found 1 day ago
$161
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Wed, Sep 2 from Hartsfield-Jackson Atlanta Intl. to Buffalo Niagara Intl., returning Sun, Sep 6, priced at $161 found 1 day ago
Frontier Airlines
Tue, Nov 10 - Sat, Nov 14
EWR
Newark Liberty Intl. Airport
BUF
Buffalo Niagara Intl.
$170 Roundtrip, found 10 hours ago
$170
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Tue, Nov 10 from Newark Liberty Intl. Airport to Buffalo Niagara Intl., returning Sat, Nov 14, priced at $170 found 10 hours ago
Frontier Airlines
Mon, Aug 31 - Tue, Sep 8
BWI
Baltimore Washington Intl. Thurgood Marshall
BUF
Buffalo Niagara Intl.
$179 Roundtrip, found 2 days ago
$179
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Aug 31 from Baltimore Washington Intl. Thurgood Marshall to Buffalo Niagara Intl., returning Tue, Sep 8, priced at $179 found 2 days ago
Frontier Airlines
Tue, Oct 6 - Tue, Oct 13
IAD
Washington Dulles Intl.
BUF
Buffalo Niagara Intl.
$180 Roundtrip, found 2 days ago
$180
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, Oct 6 from Washington Dulles Intl. to Buffalo Niagara Intl., returning Tue, Oct 13, priced at $180 found 2 days ago
Frontier Airlines
Wed, Sep 16 - Sat, Oct 3
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$182 Roundtrip, found 1 day ago
$182
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Sep 16 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 3, priced at $182 found 1 day ago
Bargain Flight
Wed, Aug 26 - Tue, Sep 1
CLT
Charlotte-Douglas Intl.
BUF
Buffalo Niagara Intl.
$202 Roundtrip, found 2 days ago
$202
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Aug 26 from Charlotte-Douglas Intl. to Buffalo Niagara Intl., returning Tue, Sep 1, priced at $202 found 2 days ago
American Airlines
Wed, Aug 26 - Wed, Sep 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$210 Roundtrip, found 2 days ago
$210
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 26 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 2, priced at $210 found 2 days ago
JetBlue Airways
Sat, Oct 17 - Sat, Oct 31
MCO
Orlando Intl.
BUF
Buffalo Niagara Intl.
$227 Roundtrip, found 2 days ago
$227
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Sat, Oct 17 from Orlando Intl. to Buffalo Niagara Intl., returning Sat, Oct 31, priced at $227 found 2 days ago
Frontier Airlines
Thu, Oct 29 - Tue, Nov 3
BNA
Nashville Intl.
BUF
Buffalo Niagara Intl.
$230 Roundtrip, found 12 hours ago
$230
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, Oct 29 from Nashville Intl. to Buffalo Niagara Intl., returning Tue, Nov 3, priced at $230 found 12 hours ago
American Airlines
Fri, Sep 11 - Mon, Sep 14
DCA
Ronald Reagan Washington National
BUF
Buffalo Niagara Intl.
$236 Roundtrip, found 5 days ago
$236
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 11 from Ronald Reagan Washington National to Buffalo Niagara Intl., returning Mon, Sep 14, priced at $236 found 5 days ago
Bargain Flight
Sat, Aug 29 - Tue, Sep 1
DFW
Dallas-Fort Worth Intl.
BUF
Buffalo Niagara Intl.
$260 Roundtrip, found 1 day ago
$260
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Aug 29 from Dallas-Fort Worth Intl. to Buffalo Niagara Intl., returning Tue, Sep 1, priced at $260 found 1 day ago
Delta
Tue, Sep 1 - Fri, Sep 11
DAL
Love Field
BUF
Buffalo Niagara Intl.
$390 Roundtrip, found 3 days ago
$390
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Sep 1 from Love Field to Buffalo Niagara Intl., returning Fri, Sep 11, priced at $390 found 3 days ago

Cheap Flights to Depew

Fall in love at first flight with your vacation to Depew by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Depew on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Depew, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Depew

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Depew with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the BUF airport.

What is the cheapest month to fly to Depew?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Depew are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Depew?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Depew.

What airport is best to fly into Depew?

When you’re planning your trip to Depew, convenience is the name of the game. Luckily, Depew Buffalo Niagara Intl. Airport is nearby so you can deplane and get going on checking off everything on your Depew must-do list.

How much are flights to Depew?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Depew on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $88, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Depew?

The trick to saving a stack of cash on your flight to Depew? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $88 right now, why wait?

Depew Flight Information
Destination airport
Buffalo Niagara Intl.
Destination airport IATA code
BUF
Roundtrip price
$88

Last Minute Hotel Deals in Depew

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the restaurant and the helpful ...
Get rates
Buffalo Airport Hotel
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the helpful staff and ...
7.6/10 Good! (2,510 reviews)
"Clean room. Staff good"

Reviewed on Aug 6, 2026

Get rates
Garden Place Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
7.4/10 Good! (2,916 reviews)
"The hotel is aging and weathered. The rooms are in dark and dingy and in need of repair and renovation. The enamel in the sink and bathroom were cracked and peeling and there were "obvious", white stains on the boxspring of one of our beds. It was very uncomfortable to sleep in. The air conditioning ..."

Reviewed on Aug 6, 2026

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M Hotel Buffalo
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Book a stay at this business-friendly hotel in Grand Island. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (2,001 reviews)
"I was booked for room with king bed got 2 queens instead"

Reviewed on Aug 6, 2026

Get rates
Holiday Inn Express Grand Island - Niagara Falls by IHG
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
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Hyatt Regency Buffalo / Hotel and Conference Center
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (2,271 reviews)
"It is fine for one night before an early flight. One of the beds in our room had hair and crumbs on the sheets. Everything else was pretty clean. I didn’t say anything to the front desk, as it took about 45 minutes to get my car parked for the “stay and park” option; I was not aware I would be waiting ..."

Reviewed on Aug 5, 2026

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Sleep Inn & Suites Buffalo Airport
Comfort Inn University

Comfort Inn University

2.5 out of 5
1 Flint Rd Buffalo NY
Book a stay at this business-friendly hotel in Buffalo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,433 reviews)
"Very very old outdated property."

Reviewed on Aug 6, 2026

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Comfort Inn University
Fairbridge Inn Express Buffalo Airport Williamsville

Fairbridge Inn Express Buffalo Airport Williamsville

2 out of 5
7200 Transit Road Buffalo NY
Stay at this hotel in Buffalo. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Walden Galleria Mall and Patriots and Heroes Park ...
4.8/10 (1,108 reviews)
"Parking was good, air conditioning worked and the room was clean"

Reviewed on Aug 5, 2026

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Fairbridge Inn Express Buffalo Airport Williamsville
See all 894 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.