Search for Cheap Deals onLuxury Hotels in Ohio River Valley
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Luxury Ohio River Valley
Conrad Indianapolis
50 W Washington St., Indianapolis, IN
Stay at this 5-star luxury hotel in Indianapolis. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
21c Museum Hotel Louisville
700 W Main Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Louisville. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the restaurant and the helpful ...
West Baden Springs Hotel
8538 W Baden Ave, West Baden Springs, IN
Stay at this 4.5-star luxury resort in West Baden Springs. Enjoy free WiFi, a full-service spa, and 15 restaurants. Popular attractions French Lick Winery and ...
21c Museum Hotel Cincinnati
609 Walnut St, Cincinnati, OH
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Cincinnati. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
The Cincinnatian Hotel Curio Collection by Hilton
601 Vine Street, Cincinnati, OH
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in Cincinnati. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff and the clean ...
The Brown Hotel
335 W Broadway, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Louisville. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the bar and the helpful ...
Galt House Hotel Trademark Collection by Wyndham
140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Louisville. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the restaurant and the helpful staff in ...
Hotel Covington Cincinnati Riverfront
638 Madison Ave, Covington, KY
Stay at this 4-star business-friendly hotel in Covington. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Embassy Suites Louisville Downtown
501 South Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Louisville. Enjoy free breakfast, room service, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff ...
Olentangy Motor Inn
1445 Olentangy River Rd, Columbus, OH
Fully refundableReserve now, pay when you stay
Stay at this hotel in Columbus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Microtel Inn by Wyndham Louisville East
1221 Kentucky Mills Drive, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Quality Inn Mason Near Kings Island
5589 Kings Mills Rd, Mason, OH
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in Mason. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Ohio River Valley
- Hotels with Free Parking in Ohio River Valley
- Family Hotels in Ohio River Valley
- Hotels with a Pool in Ohio River Valley
- Pet-friendly Hotels in Ohio River Valley
- Hotels with an Indoor Pool in Ohio River Valley
- Historic Hotels in Ohio River Valley
- Hotels with Hot Tubs in Ohio River Valley
- Hotel Wedding Venues in Ohio River Valley
- Resorts & Hotels with Spas in Ohio River Valley
- Winery Hotels in Ohio River Valley
Ohio River Valley Neighborhoods
- Downtown Indianapolis Hotels (65.08 mi)
- Downtown Louisville Hotels (115.06 mi)
- Downtown Cincinnati Hotels (52.99 mi)
- Downtown Columbus Hotels (103.14 mi)
- Polaris Hotels (106.37 mi)
- Downtown Lexington Hotels (122.98 mi)
- Short North Hotels (103.23 mi)
- Near Eastside Hotels (62.21 mi)
- Over-the-Rhine Hotels (52.28 mi)
- Worthington Hotels (103.68 mi)
- Speedway Hotels (69.68 mi)
- Jeffersontown Hotels (115.5 mi)
- University District Hotels (103.18 mi)
- Norwood Hotels (50.55 mi)
- Castleton Hotels (59.54 mi)
- German Village Hotels (103.64 mi)
- St. Matthews Hotels (113.09 mi)
- Gahanna Hotels (110.11 mi)
- West Main Historic District Hotels (115.16 mi)
- Old Louisville Hotels (116.42 mi)
Top Points of Interests in Ohio River Valley
- Hotels near Kings Island
- Hotels near Ark Encounter
- Hotels near Indianapolis Motor Speedway
- Hotels near Lucas Oil Stadium
- Hotels near Ohio State University
- Hotels near Gainbridge Fieldhouse
- Hotels near Great American Ball Park
- Hotels near University of Illinois at Urbana-Champaign
- Hotels near Hocking Hills State Park
- Hotels near Purdue University
- Hotels near Indiana University Bloomington
- Hotels near Greater Columbus Convention Center
- Hotels near Columbus Zoo and Aquarium
- Hotels near Kentucky Exposition Center
- Hotels near Indiana Convention Center
- Hotels near Easton Town Center
- Hotels near Newport Aquarium
- Hotels near University of Cincinnati
- Hotels near Paycor Stadium
- Hotels near Kentucky Horse Park
Cities near Ohio River Valley
- Sandusky Hotels (163.51 mi)
- Logan Hotels (135.63 mi)
- Erie Hotels (299.93 mi)
- South Bend Hotels (147.02 mi)
- Dayton Hotels (39.61 mi)
- Bloomington Hotels (95.49 mi)
- Michigan City Hotels (167.12 mi)
- Champaign Hotels (176.38 mi)
- Rockbridge Hotels (129.18 mi)
- Akron Hotels (200.4 mi)
- Evansville Hotels (188.81 mi)
- Nashville Hotels (80.7 mi)
- North East Hotels (314.01 mi)
- Florence Hotels (57.17 mi)
- Mason Hotels (44.89 mi)
- Geneva-on-the-Lake Hotels (252.24 mi)
- Millersburg Hotels (167.72 mi)
Car Rentals Near Ohio River Valley
- Car rentals in Sandusky
- Car rentals in Logan
- Car rentals in Erie
- Car rentals in South Bend
- Car rentals in Dayton
- Car rentals in Bloomington
- Car rentals in Michigan City
- Car rentals in Champaign
- Car rentals in Rockbridge
- Car rentals in Akron
- Car rentals in Evansville
- Car rentals in Nashville
- Car rentals in North East
- Car rentals in Florence
- Car rentals in Mason
- Car rentals in Geneva-on-the-Lake
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels
Top Booked Hotels in Ohio River Valley
- Hilton Cincinnati Netherland Plaza
- Radisson Hotel Cincinnati Riverfront
- Galt House Hotel Trademark Collection by Wyndham
- Omni Louisville Hotel
- Hyatt Regency Cincinnati
- Ironworks Hotel Indy
- Radisson Hotel Louisville North
- Wyndham Columbus
- Omni Severin Hotel
- The Westin Cincinnati
- Embassy Suites by Hilton Cincinnati RiverCenter