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Featured 5 Star Otay Mesa Hotels
Fully refundableReserve now, pay when you stay
The price is $382 per night from Nov 24 to Nov 25
$382
includes taxes & fees
Nov 24 - Nov 25
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Fully refundableReserve now, pay when you stay
The price is $299 per night from Dec 10 to Dec 11
$299
includes taxes & fees
Dec 10 - Dec 11
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
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- Hotels with Free Parking in Otay Mesa
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- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
Popular Otay Mesa Hotels
- Wyndham Garden San Diego Near SeaWorld
- Manchester Grand Hyatt San Diego
- Wyndham San Diego Bayside
- Best Western Seven Seas
- The Dana on Mission Bay
- San Diego Mission Bay Resort
- Paradise Point Resort & Spa
- Days Inn by Wyndham San Diego Hotel Circle
- Comfort Inn Sea World Area
- Hyatt Regency Mission Bay Spa and Marina
- Hilton San Diego Mission Valley
- Best Western Plus Marina Gateway Hotel
Top Attractions in Otay Mesa
- Hotels near San Diego Zoo (15.96 mi)
- Hotels near San Diego Convention Center (14.93 mi)
- Hotels near San Ysidro Border Crossing (3.44 mi)
- Hotels near Mission Bay (21.06 mi)
- Hotels near Petco Park (14.77 mi)
- Hotels near Mission Beach (21.83 mi)
- Hotels near Naval Base San Diego (11.88 mi)
- Hotels near Balboa Park (15.52 mi)
- Hotels near Marine Corps Recruit Depot (18.04 mi)
- Hotels near Hotel Circle (18.15 mi)
- Hotels near San Diego State University (15.83 mi)
- Hotels near Port of San Diego (15.92 mi)
- Hotels near Hotel del Coronado (14.54 mi)
- Hotels near University of San Diego (19.36 mi)
- Hotels near B Street Cruise Ship Terminal (15.99 mi)
- Hotels near Las Americas Premium Outlets (4.1 mi)
- Hotels near USS Midway Museum (15.84 mi)
- Hotels near Coronado Beach (15.09 mi)
- Hotels near Seaport Village (15.41 mi)
- Hotels near Naval Base Coronado (16.63 mi)
Nearby Cities
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Rosarito Hotels (14.31 mi)
- El Cajon Hotels (16.26 mi)
- Coronado Island Hotels (16.04 mi)
- National City Hotels (10.98 mi)
- Southern California Hotels (91.04 mi)
- San Ysidro Hotels (4.08 mi)
- La Mesa Hotels (14.67 mi)
- Alpine Hotels (22.51 mi)
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