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Featured Otay Mesa Family Hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (1,406 reviews)
"Close to the airport"
Reviewed on Apr 21, 2025
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7/10 Good! (1,000 reviews)
"location was ok. location is close to cbx"
Reviewed on Apr 4, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
Top Points of Interests in Otay Mesa
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near Petco Park
- Hotels near Mission Beach
- Hotels near San Ysidro Border Crossing
- Hotels near San Diego State University
- Hotels near Balboa Park
- Hotels near Hotel Circle
- Hotels near Naval Base San Diego
- Hotels near Marine Corps Recruit Depot
- Hotels near Coronado Beach
- Hotels near Port of San Diego
- Hotels near University of San Diego
- Hotels near USS Midway Museum
- Hotels near Seaport Village
- Hotels near Mission Beach Boardwalk
- Hotels near Hotel del Coronado
- Hotels near Naval Base Coronado
Cities near Otay Mesa
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Rosarito Hotels (14.31 mi)
- Coronado Island Hotels (16.04 mi)
- El Cajon Hotels (16.26 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- La Mesa Hotels (14.67 mi)
- Imperial Beach Hotels (8.3 mi)
- San Ysidro Hotels (4.08 mi)
- Tecate Hotels (19.72 mi)
- Alpine Hotels (22.51 mi)
- Santee Hotels (19.26 mi)
- San Diego Coast Hotels (24.31 mi)
- Bonita Hotels (7.71 mi)
- Spring Valley Hotels (12.88 mi)
- Lakeside Hotels (20.78 mi)
- Jamul Hotels (12.26 mi)
Car Rentals Near Otay Mesa
- Car rentals in San Diego
- Car rentals in Coronado
- Car rentals in Chula Vista
- Car rentals in Playas de Rosarito
- Car rentals in Rosarito
- Car rentals in Coronado Island
- Car rentals in El Cajon
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in La Mesa
- Car rentals in Imperial Beach
- Car rentals in San Ysidro
- Car rentals in Tecate
- Car rentals in Alpine
- Car rentals in Santee
- Car rentals in San Diego Coast
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Otay Mesa
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- San Diego Mission Bay Resort
- Wyndham San Diego Bayside
- The Dana on Mission Bay
- Hyatt Regency Mission Bay Spa and Marina
- Paradise Point Resort & Spa
- Hilton San Diego Mission Valley
- Handlery Hotel
- Bahia Resort Hotel
- Humphreys Half Moon Inn
- Best Western Seven Seas
- Kings Inn San Diego
- Wyndham Garden San Diego Near SeaWorld
- DoubleTree by Hilton Hotel San Diego - Mission Valley