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Featured Otay Mesa Family Hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (1,402 reviews)
"Breakfast was good. Parking was available."
Reviewed on May 5, 2025
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7/10 Good! (1,001 reviews)
"Good"
Reviewed on May 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
Top Points of Interests in Otay Mesa
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near Petco Park
- Hotels near San Ysidro Border Crossing
- Hotels near Mission Beach
- Hotels near Balboa Park
- Hotels near San Diego State University
- Hotels near Hotel Circle
- Hotels near Naval Base San Diego
- Hotels near University of San Diego
- Hotels near Coronado Beach
- Hotels near Marine Corps Recruit Depot
- Hotels near USS Midway Museum
- Hotels near Port of San Diego
- Hotels near Seaport Village
- Hotels near Mission Beach Boardwalk
- Hotels near Hotel del Coronado
- Hotels near Naval Base Coronado
Cities near Otay Mesa
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Rosarito Hotels (14.31 mi)
- El Cajon Hotels (16.26 mi)
- Coronado Island Hotels (16.04 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- La Mesa Hotels (14.67 mi)
- Imperial Beach Hotels (8.3 mi)
- San Ysidro Hotels (4.08 mi)
- Tecate Hotels (19.72 mi)
- Santee Hotels (19.26 mi)
- Alpine Hotels (22.51 mi)
- Spring Valley Hotels (12.88 mi)
- San Diego Coast Hotels (24.31 mi)
- Lakeside Hotels (20.78 mi)
- Bonita Hotels (7.71 mi)
- Lemon Grove Hotels (13.08 mi)
Car Rentals Near Otay Mesa
- Car rentals in San Diego
- Car rentals in Coronado
- Car rentals in Chula Vista
- Car rentals in Playas de Rosarito
- Car rentals in Rosarito
- Car rentals in El Cajon
- Car rentals in Coronado Island
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in La Mesa
- Car rentals in Imperial Beach
- Car rentals in San Ysidro
- Car rentals in Tecate
- Car rentals in Santee
- Car rentals in Alpine
- Car rentals in Spring Valley
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Otay Mesa
- Days Inn by Wyndham San Diego Hotel Circle
- San Diego Mission Bay Resort
- The Dana on Mission Bay
- Loews Coronado Bay Resort
- Wyndham San Diego Bayside
- Kings Inn San Diego
- Hyatt Regency Mission Bay Spa and Marina
- Manchester Grand Hyatt San Diego
- Hilton San Diego Mission Valley
- Sheraton San Diego Resort
- Wyndham Garden San Diego Near SeaWorld
- Sheraton Mission Valley San Diego Hotel
- Handlery Hotel