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Featured 4 Star Otay Mesa Hotels
Fully refundableReserve now, pay when you stay
The price is $238 per night from Dec 24 to Dec 25
$238
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Fully refundableReserve now, pay when you stay
The price is $251 per night from Dec 30 to Dec 31
$251
includes taxes & fees
Dec 30 - Dec 31
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Fully refundableReserve now, pay when you stay
The price is $141 per night from Dec 29 to Dec 30
$141
includes taxes & fees
Dec 29 - Dec 30
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
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Fully refundable
The price is $184 per night from Dec 24 to Dec 25
$184
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Fully refundableReserve now, pay when you stay
The price is $163 per night from Dec 29 to Dec 30
$163
includes taxes & fees
Dec 29 - Dec 30
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
Fully refundableReserve now, pay when you stay
The price is $171 per night from Jan 1 to Jan 2
$171
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Fully refundableReserve now, pay when you stay
The price is $266 per night from Dec 24 to Dec 25
$266
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Fully refundableReserve now, pay when you stay
The price is $232 per night from Dec 24 to Dec 25
$232
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Fully refundableReserve now, pay when you stay
The price is $174 per night from Jan 5 to Jan 6
$174
includes taxes & fees
Jan 5 - Jan 6, 2025
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
Fully refundableReserve now, pay when you stay
The price is $206 per night from Dec 24 to Dec 25
$206
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Fully refundableReserve now, pay when you stay
The price is $230 per night from Jan 5 to Jan 6
$230
includes taxes & fees
Jan 5 - Jan 6, 2025
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff in ...
Fully refundableReserve now, pay when you stay
The price is $141 per night from Dec 30 to Dec 31
$141
includes taxes & fees
Dec 30 - Dec 31
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
Popular Otay Mesa Hotels
Top Attractions in Otay Mesa
- Hotels near San Diego Zoo (15.96 mi)
- Hotels near San Diego Convention Center (14.93 mi)
- Hotels near San Ysidro Border Crossing (3.44 mi)
- Hotels near Mission Bay (21.06 mi)
- Hotels near Balboa Park (15.52 mi)
- Hotels near Mission Beach (21.83 mi)
- Hotels near Naval Base San Diego (11.88 mi)
- Hotels near Petco Park (14.77 mi)
- Hotels near Port of San Diego (15.92 mi)
- Hotels near Marine Corps Recruit Depot (18.04 mi)
- Hotels near Hotel Circle (18.15 mi)
- Hotels near USS Midway Museum (15.84 mi)
- Hotels near Las Americas Premium Outlets (4.1 mi)
- Hotels near San Diego State University (15.83 mi)
- Hotels near Mission Beach Boardwalk (21.43 mi)
- Hotels near Hotel del Coronado (14.54 mi)
- Hotels near B Street Cruise Ship Terminal (15.99 mi)
- Hotels near University of San Diego (19.36 mi)
- Hotels near Naval Base Coronado (16.63 mi)
- Hotels near Coronado Beach (15.09 mi)
Nearby Cities
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Rosarito Hotels (14.31 mi)
- Playas de Rosarito Hotels (21.71 mi)
- El Cajon Hotels (16.26 mi)
- Coronado Island Hotels (16.04 mi)
- National City Hotels (10.98 mi)
- Southern California Hotels (91.04 mi)
- San Ysidro Hotels (4.08 mi)
- La Mesa Hotels (14.67 mi)
- Alpine Hotels (22.51 mi)
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