Search for Cheap Deals on4 Star Hotels in Otay Mesa
Check Last Minute Otay Mesa Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured 4 Star Otay Mesa Hotels
Fully refundableReserve now, pay when you stay
The price is $133 per night from Mar 31 to Apr 1
$133
includes taxes & fees
Mar 31 - Apr 1
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Fully refundableReserve now, pay when you stay
The price is $234 per night from Mar 26 to Mar 27
$234
includes taxes & fees
Mar 26 - Mar 27
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Fully refundableReserve now, pay when you stay
The price is $268 per night from Apr 18 to Apr 19
$268
includes taxes & fees
Apr 18 - Apr 19
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Save an average of 15% on thousands of hotels when you're signed in
Fully refundableReserve now, pay when you stay
The price is $242 per night from Apr 20 to Apr 21
$242
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
Fully refundableReserve now, pay when you stay
The price is $171 per night from Mar 30 to Mar 31
$171
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Fully refundableReserve now, pay when you stay
The price is $212 per night from Apr 20 to Apr 21
$212
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 5 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
Fully refundableReserve now, pay when you stay
The price is $264 per night from Mar 30 to Mar 31
$264
includes taxes & fees
Mar 30 - Mar 31
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
Fully refundableReserve now, pay when you stay
The price is $278 per night from Mar 27 to Mar 28
$278
includes taxes & fees
Mar 27 - Mar 28
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Fully refundableReserve now, pay when you stay
The price is $157 per night from Mar 30 to Mar 31
$157
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
Fully refundableReserve now, pay when you stay
The price is $261 per night from Apr 17 to Apr 18
$261
includes taxes & fees
Apr 17 - Apr 18
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Fully refundableReserve now, pay when you stay
The price is $232 per night from Mar 25 to Mar 26
$232
includes taxes & fees
Mar 25 - Mar 26
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Fully refundableReserve now, pay when you stay
The price is $224 per night from Mar 30 to Mar 31
$224
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
Popular Otay Mesa Hotels
- The Dana on Mission Bay
- Wyndham San Diego Bayside
- San Diego Mission Bay Resort
- Best Western Seven Seas
- Comfort Inn Sea World Area
- Loews Coronado Bay Resort
- Paradise Point Resort & Spa
- Humphreys Half Moon Inn
- Handlery Hotel
- Sheraton San Diego Resort
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Top Attractions in Otay Mesa
- Hotels near Cross Border Xpress (0.76 mi)
- Hotels near San Diego Zoo (15.96 mi)
- Hotels near San Diego Convention Center (14.93 mi)
- Hotels near Mission Bay (21.06 mi)
- Hotels near San Ysidro Border Crossing (3.44 mi)
- Hotels near Balboa Park (15.52 mi)
- Hotels near Petco Park (14.77 mi)
- Hotels near Mission Beach (21.83 mi)
- Hotels near San Diego State University (15.83 mi)
- Hotels near Hotel Circle (18.15 mi)
- Hotels near Marine Corps Recruit Depot (18.04 mi)
- Hotels near Port of San Diego (15.92 mi)
- Hotels near Naval Base San Diego (11.88 mi)
- Hotels near Coronado Beach (15.09 mi)
- Hotels near USS Midway Museum (15.84 mi)
- Hotels near University of San Diego (19.36 mi)
- Hotels near Mission Beach Boardwalk (21.43 mi)
- Hotels near B Street Cruise Ship Terminal (15.99 mi)
- Hotels near Hotel del Coronado (14.54 mi)
- Hotels near Seaport Village (15.41 mi)
Nearby Cities
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Rosarito Hotels (14.31 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Coronado Island Hotels (16.04 mi)
- El Cajon Hotels (16.26 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- La Mesa Hotels (14.67 mi)
- Imperial Beach Hotels (8.3 mi)
- San Ysidro Hotels (4.08 mi)
Recommended cities for you
- Las Vegas Hotels
- New York Hotels
- Orlando Hotels
- Los Angeles Hotels
- Miami Hotels
- San Francisco Hotels
- New Orleans Hotels
- Chicago Hotels
- Fort Lauderdale Hotels
- Boston Hotels
- Honolulu Hotels
- San Diego Hotels
- Washington Hotels
- Toronto Hotels
- Anaheim Hotels
- Atlanta Hotels
- Nashville Hotels
- Seattle Hotels
- Phoenix Hotels
- Myrtle Beach Hotels
Car Rentals Near Otay Mesa
- Car rentals in San Diego
- Car rentals in Coronado
- Car rentals in Chula Vista
- Car rentals in Rosarito
- Car rentals in Playas de Rosarito
- Car rentals in Coronado Island
- Car rentals in El Cajon
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in La Mesa
- Car rentals in Imperial Beach
- Car rentals in San Ysidro
- Car rentals in Alpine
- Car rentals in Santee
- Car rentals in Tecate
- Car rentals in Bonita