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Featured 4 Star Otay Mesa Hotels
![San Diego Marriott Gaslamp Quarter](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/04fbf5a2_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
The price is $191 per night from Feb 21 to Feb 22
$191
includes taxes & fees
Feb 21 - Feb 22
Book a stay at this business-friendly hotel in San Diego. Enjoy 2 bars/lounges, a nightclub, and breakfast (surcharge). Our guests praise the bar and the helpful ...
![Hyatt Regency Mission Bay Spa and Marina](https://images.trvl-media.com/lodging/1000000/10000/900/858/88182041_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $234 per night from Feb 23 to Feb 24
$234
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/c125cfc7_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $232 per night from Mar 16 to Mar 17
$232
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
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![Omni San Diego Hotel](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/7ce05f44_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
The price is $241 per night from Mar 14 to Mar 15
$241
includes taxes & fees
Mar 14 - Mar 15
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/7d206d74_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
The price is $261 per night from Mar 9 to Mar 10
$261
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
![Hotel Indigo San Diego-Gaslamp Quarter, an IHG Hotel](https://images.trvl-media.com/lodging/3000000/2480000/2471900/2471812/2606f950_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundable
The price is $272 per night from Feb 22 to Feb 23
$272
includes taxes & fees
Feb 22 - Feb 23
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
![Loews Coronado Bay Resort](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/cb266766_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $278 per night from Mar 2 to Mar 3
$278
includes taxes & fees
Mar 2 - Mar 3
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/09e8af14_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $181 per night from Mar 6 to Mar 7
$181
includes taxes & fees
Mar 6 - Mar 7
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
![Marriott Marquis San Diego Marina](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/29c5ca01_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $245 per night from Mar 7 to Mar 8
$245
includes taxes & fees
Mar 7 - Mar 8
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff in ...
![Alma San Diego Downtown, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/3000000/2140000/2133600/2133509/a326df8d_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $196 per night from Feb 22 to Feb 23
$196
includes taxes & fees
Feb 22 - Feb 23
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
![Hilton San Diego Bayfront](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/c1f423a4_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
The price is $230 per night from Mar 14 to Mar 15
$230
includes taxes & fees
Mar 14 - Mar 15
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
![Lafayette Hotel & Club](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd4336c7_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Fully refundableReserve now, pay when you stay
The price is $232 per night from Feb 19 to Feb 20
$232
includes taxes & fees
Feb 19 - Feb 20
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
Popular Otay Mesa Hotels
Top Attractions in Otay Mesa
- Hotels near San Diego Zoo (15.96 mi)
- Hotels near San Diego Convention Center (14.93 mi)
- Hotels near Mission Bay (21.06 mi)
- Hotels near San Ysidro Border Crossing (3.44 mi)
- Hotels near Balboa Park (15.52 mi)
- Hotels near Mission Beach (21.83 mi)
- Hotels near Petco Park (14.77 mi)
- Hotels near San Diego State University (15.83 mi)
- Hotels near Hotel Circle (18.15 mi)
- Hotels near Naval Base San Diego (11.88 mi)
- Hotels near USS Midway Museum (15.84 mi)
- Hotels near Marine Corps Recruit Depot (18.04 mi)
- Hotels near Port of San Diego (15.92 mi)
- Hotels near Coronado Beach (15.09 mi)
- Hotels near Hotel del Coronado (14.54 mi)
- Hotels near University of San Diego (19.36 mi)
- Hotels near B Street Cruise Ship Terminal (15.99 mi)
- Hotels near Mission Beach Boardwalk (21.43 mi)
- Hotels near Seaport Village (15.41 mi)
- Hotels near Naval Base Coronado (16.63 mi)
Nearby Cities
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Rosarito Hotels (14.31 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Coronado Island Hotels (16.04 mi)
- El Cajon Hotels (16.26 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- La Mesa Hotels (14.67 mi)
- Imperial Beach Hotels (8.3 mi)
- San Ysidro Hotels (4.08 mi)
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