Search for Cheap Deals onLuxury Hotels in Otay Mesa
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Luxury Otay Mesa
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
Top Points of Interests in Otay Mesa
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near Mission Beach
- Hotels near San Ysidro Border Crossing
- Hotels near Petco Park
- Hotels near San Diego State University
- Hotels near Balboa Park
- Hotels near Port of San Diego
- Hotels near Marine Corps Recruit Depot
- Hotels near Hotel Circle
- Hotels near Naval Base San Diego
- Hotels near Coronado Beach
- Hotels near University of San Diego
- Hotels near USS Midway Museum
- Hotels near Seaport Village
- Hotels near Mission Beach Boardwalk
- Hotels near B Street Cruise Ship Terminal
- Hotels near Hotel del Coronado
Cities near Otay Mesa
- San Diego Hotels (15.34 mi)
- Coronado Hotels (14.99 mi)
- Chula Vista Hotels (8.51 mi)
- Rosarito Hotels (14.31 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Coronado Island Hotels (16.04 mi)
- El Cajon Hotels (16.26 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- La Mesa Hotels (14.67 mi)
- Imperial Beach Hotels (8.3 mi)
- San Ysidro Hotels (4.08 mi)
- Alpine Hotels (22.51 mi)
- Tecate Hotels (19.72 mi)
- Santee Hotels (19.26 mi)
- San Diego Coast Hotels (24.31 mi)
- Bonita Hotels (7.71 mi)
- Spring Valley Hotels (12.88 mi)
- Lakeside Hotels (20.78 mi)
- Jamul Hotels (12.26 mi)
Car Rentals Near Otay Mesa
- Car rentals in San Diego
- Car rentals in Coronado
- Car rentals in Chula Vista
- Car rentals in Rosarito
- Car rentals in Playas de Rosarito
- Car rentals in Coronado Island
- Car rentals in El Cajon
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in La Mesa
- Car rentals in Imperial Beach
- Car rentals in San Ysidro
- Car rentals in Alpine
- Car rentals in Tecate
- Car rentals in Santee
- Car rentals in San Diego Coast
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels
Top Booked Hotels in Otay Mesa
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- Wyndham San Diego Bayside
- San Diego Mission Bay Resort
- The Dana on Mission Bay
- Paradise Point Resort & Spa
- Hilton San Diego Mission Valley
- Bahia Resort Hotel
- Humphreys Half Moon Inn
- Wyndham Garden San Diego Near SeaWorld
- Best Western Seven Seas
- Kings Inn San Diego