Hotels Near
Otay Mesa West

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Featured Otay Mesa West Hotels

Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.4/10 Very Good! (1,963 reviews)
"Awesome spot for price 🙏"

Reviewed on Dec 19, 2024

Paradise Point Resort & Spa
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,529 reviews)
"Great location. Rooms on the smaller side. But would stay again."

Reviewed on Dec 19, 2024

Wyndham San Diego Bayside
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
7.2/10 Good! (3,640 reviews)
"Overall pretty good but has its defects inside the hotel but definitely worth the price"

Reviewed on Dec 19, 2024

Wyndham Garden San Diego Near SeaWorld
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (2,944 reviews)
"Excellent place for a great price."

Reviewed on Dec 18, 2024

The Dana on Mission Bay
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,265 reviews)
"The room was very comfortable. The free breakfast was a really nice bonus."

Reviewed on Dec 17, 2024

Comfort Inn Sea World Area
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (2,836 reviews)
"Good in general"

Reviewed on Dec 17, 2024

Manchester Grand Hyatt San Diego
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,107 reviews)
"Great"

Reviewed on Dec 16, 2024

San Diego Mission Bay Resort
Bay Club Hotel & Marina
Bay Club Hotel & Marina
3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
9/10 Wonderful! (2,336 reviews)
A Special Trip
"My husband and I came here to celebrate our one year of marriage—but little did I know, the room I booked had a tiny patio and an entire tree blocking our view. I spoke to the front desk about it and they showed me kindness and empathy, going above and beyond to help remedy the situation. Our room ..."

Reviewed on Dec 20, 2024

Bay Club Hotel & Marina
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,260 reviews)
Well done!👏
"Amazing stay with excellent cleanliness. Staff was very friendly and accomodating."

Reviewed on Dec 17, 2024

Sheraton Mission Valley San Diego Hotel
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4 out of 5
1 Park Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (1,503 reviews)
"Great hotel"

Reviewed on Dec 15, 2024

Hilton San Diego Bayfront
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,483 reviews)
"Staff not friendly. Construction going on Not up to Sheraton standards"

Reviewed on Dec 17, 2024

Sheraton San Diego Hotel and Marina
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (500 reviews)
"This place is super pretty, but the check-in area is not that great. The staff was super friendly and kind, but I think it is somewhat stressful. You have the poor staff doing check-in and lattes at the same time. Additionally, you had everyone that was checking in and wanting a latte in the same ..."

Reviewed on Dec 16, 2024

Lafayette Hotel & Club
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa West

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa West. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa West has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa West hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa West underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa West city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa West cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa West at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $100
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa West hotel you want, book it, and never look back. Because your great escape is ahead of you.