Hotels Near
Otay Mesa West

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Featured Otay Mesa West Hotels

The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (3,255 reviews)
"Absolutely gorgeous property."

Reviewed on Mar 7, 2025

The Dana on Mission Bay
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,319 reviews)
"I like how close it is to the attractions in SD. However, I didn’t like how the rooms, especially the ones close to the freeway, seem to not have any soundproofing. You can hear the cars on the freeway."

Reviewed on Mar 8, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,144 reviews)
More like 3-Star hotel
"Our first room had a lot of challenges- broken phone, television, internet. So they changed our room with a “free upgrade” by all it included was slightly more room and a bay view, that was heavily populated by strangers walking by."

Reviewed on Mar 6, 2025

San Diego Mission Bay Resort
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,713 reviews)
"Wonderful"

Reviewed on Mar 8, 2025

Comfort Inn Sea World Area
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,638 reviews)
"Definitely an older property with smallish rooms. $10 a day if you want a microwave. $50 a day self parking. Wonderful bay view. Would stay again but look for deals."

Reviewed on Mar 7, 2025

Wyndham San Diego Bayside
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9/10 Wonderful! (1,878 reviews)
"very nice -- pleasant staff"

Reviewed on Mar 8, 2025

Omni San Diego Hotel
The Little Italy Hotel Downtown San Diego
The Little Italy Hotel Downtown San Diego
4 out of 5
1646 Front St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a sauna, and parking (surcharge). Our guests praise the helpful staff in our reviews. ...
7.6/10 Good! (1,007 reviews)
"Don’t need to put a review unless I have something to complain about"

Reviewed on Mar 5, 2025

The Little Italy Hotel Downtown San Diego
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 5 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,567 reviews)
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Reviewed on Mar 7, 2025

Sheraton San Diego Resort
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9/10 Wonderful! (2,180 reviews)
"The hotel is very beautiful. You feel like you’re in a tropical oasis. The staff are very friendly. The only problem we had was the cleanliness of the room. There were stains on the sheets, blood running down the toilet, sticky stuff all over the coffee table and when we opened the pullout bed it ..."

Reviewed on Mar 8, 2025

Humphreys Half Moon Inn
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (2,610 reviews)
"Professional and friendly staff. Very comfortable bedding"

Reviewed on Mar 8, 2025

Hard Rock Hotel San Diego
Best Western Seven Seas
Best Western Seven Seas
3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.6/10 Good! (2,652 reviews)
"Great pplace"

Reviewed on Mar 7, 2025

Best Western Seven Seas
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,342 reviews)
"Victor at the front desk was accommodating and so helpful upon arrival after a day’s travel. He was a god’s send. No wall hooks for towels in the bathroom is the only complaint. I would stay again!"

Reviewed on Mar 6, 2025

Sheraton Mission Valley San Diego Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa West

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa West. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa West has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa West hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa West underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa West city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa West cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa West at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $102
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa West hotel you want, book it, and never look back. Because your great escape is ahead of you.