Hotels Near
Otay Mesa West

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Featured Otay Mesa West Hotels

San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,183 reviews)
"Perfect location on the quiet part of the bay. Loved the walking path along the bay. Staff was very friendly, pool was great and heated and the room with the fire pit was excellent, used the fire pit both nights. Definitely will be back and worth it."

Reviewed on Apr 24, 2025

San Diego Mission Bay Resort
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,532 reviews)
Best place to stay
"The check in was fast directions to our room was easy to follow rooms are quiet. Breakfast room was clean and plenty to eat i would stay there again right near the freeway but i never heard the traffic."

Reviewed on Apr 24, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,671 reviews)
"I loved the view from the balcony. Beautiful city lights."

Reviewed on Apr 24, 2025

Wyndham San Diego Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,340 reviews)
"Movies at the pool every night for kids"

Reviewed on Apr 24, 2025

The Dana on Mission Bay
Hilton San Diego Mission Valley
Hilton San Diego Mission Valley
4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
7.8/10 Good! (1,617 reviews)
"very good"

Reviewed on Apr 25, 2025

Hilton San Diego Mission Valley
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8/10 Very Good! (1,691 reviews)
"It’s ok. Pool area great including the restaurant that serves poolside. A bit old and only provided caffeine free coffee (huh??? Checked housekeeping cart and all caffeine free) Don’t love high parking fee. You won’t be upset.. you won’t be wowed either. But it’s a good safe and nice place to ..."

Reviewed on Apr 24, 2025

Handlery Hotel
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (2,147 reviews)
"Love this resort with all the wildlife and pools and friendly staff. We did have a ton of ants in room 602 when we moved rooms. They were all over the bathroom. Other than that everything was wonderful."

Reviewed on Apr 24, 2025

Paradise Point Resort & Spa
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (773 reviews)

Reviewed on Apr 24, 2025

Lafayette Hotel & Club
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9.2/10 Wonderful! (2,271 reviews)
"I love staying at Humphreys as well as my family. Staff is amazing here even remembering us from a year ago when we had last booked to stay there. Pool and jacuzzi is wonderful. The food at the bar is pretty good as well as the drinks. I will continue to book stays here as much as I can."

Reviewed on Apr 23, 2025

Humphreys Half Moon Inn
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,214 reviews)
":)"

Reviewed on Apr 24, 2025

Kings Inn San Diego
Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free parking, a beach locale, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (1,519 reviews)
"Nice place, good location. Easy parking"

Reviewed on Apr 20, 2025

Bahia Resort Hotel
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
7.2/10 Good! (3,845 reviews)
"Nice stay"

Reviewed on Apr 24, 2025

Wyndham Garden San Diego Near SeaWorld
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa West

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa West. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa West has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa West hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa West underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa West city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa West cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa West at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $112
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa West hotel you want, book it, and never look back. Because your great escape is ahead of you.