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Hotels in South San Diego

Choose from 7526 South San Diego Hotel Deals

Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center

4 out of 5
1000 H Street, Chula Vista, CA
  • 15 min drive from Las Americas Premium Outlets
Stay at this 4-star spa hotel in Chula Vista. Enjoy 3 outdoor pools, a full-service spa, and 8 restaurants. Popular attractions San Diego Bay and Hotel del Coronado ...
7.8/10 Good! (42 reviews)
"Very nice hotel"

Reviewed on Jul 14, 2025

Gaylord Pacific Resort & Convention Center
The Rambler Motel

The Rambler Motel

3 out of 5
225 Bay Blvd, Chula Vista, CA
  • 16 min drive from Las Americas Premium Outlets
Stay at this 3-star business-friendly motel in Chula Vista. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (1,876 reviews)
"This is a fun little space to just chill and find new adventures."

Reviewed on Jul 21, 2025

The Rambler Motel
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
  • 8 min drive from Las Americas Premium Outlets
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,403 reviews)
"The property was clean, quiet, and conveniently located. The staff was friendly and helpful throughout our stay. The room was well-equipped and the bed very comfortable."

Reviewed on Jul 18, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
  • 37 min drive from Las Americas Premium Outlets
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,885 reviews)
"It was a nice, quiet area. Perfect for a lowkey getaway"

Reviewed on Jul 20, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
  • 30 min drive from Las Americas Premium Outlets
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,750 reviews)
"great location"

Reviewed on Jul 21, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
  • 29 min drive from Las Americas Premium Outlets
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,775 reviews)
"Great hotel with lots going on."

Reviewed on Jul 18, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
  • 38 min drive from Las Americas Premium Outlets
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,569 reviews)
"Amazing Property and Experience"

Reviewed on Jul 18, 2025

The Dana on Mission Bay
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
  • 29 min drive from Las Americas Premium Outlets
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,770 reviews)
"Great hotel, everything nice"

Reviewed on Jul 19, 2025

Marriott Marquis San Diego Marina
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
  • 31 min drive from Las Americas Premium Outlets
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.6/10 Good! (1,024 reviews)
"In a good place downtown"

Reviewed on Jul 20, 2025

The Dextro Hotel, BW Premier Collection
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
  • 37 min drive from Las Americas Premium Outlets
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,834 reviews)
"Hotel was conveniently located clean area and great size room, hated I had to pay for parking but overall great"

Reviewed on Jul 19, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

4 out of 5
1646 Front St, San Diego, CA
  • 31 min drive from Las Americas Premium Outlets
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,014 reviews)
"Nice property but didn’t like paying for parking. I’m already paying for the room and the parking was really tight."

Reviewed on Jul 17, 2025

The Little Italy Hotel Downtown San Diego
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
  • 31 min drive from Las Americas Premium Outlets
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...
9/10 Wonderful! (2,736 reviews)
"Great place to stay"

Reviewed on Jul 19, 2025

Bay Club Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Diego

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $110. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Diego hotel deals at the last minute.

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Frequently Asked Questions About South San Diego hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in South San Diego?

With over 7,526 hotels in South San Diego, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $110.

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Finding a cheap car rental deal in South San Diego is as easy as scoring cheap hotels in South San Diego. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.