Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (3,180 reviews)
"Was okay"

Reviewed on Feb 20, 2025

The Dana on Mission Bay
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,615 reviews)
"Convention location, clean room and friendly staff!"

Reviewed on Feb 20, 2025

Wyndham San Diego Bayside
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9/10 Wonderful! (1,844 reviews)
"Nice location and hotel"

Reviewed on Feb 20, 2025

Omni San Diego Hotel
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (2,585 reviews)
"It was a great stay staff super professional"

Reviewed on Feb 21, 2025

Hard Rock Hotel San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,454 reviews)
"Great experience. Pool and waterslides were perfect for my 6 and 3 year old boys. Hotel room was beautiful. We will come again. Breakfast was mediocre. Service was ok. Waiter was passive aggressive. Could have done without."

Reviewed on Feb 18, 2025

Hyatt Regency Mission Bay Spa and Marina
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,639 reviews)
"Courteous and welcoming reception! Superb rooms, cleanroom, equipped with everything I needed. The third stay and will be back"

Reviewed on Feb 21, 2025

Comfort Inn Sea World Area
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,321 reviews)
"Super nice hotel and workers"

Reviewed on Feb 18, 2025

Sheraton Mission Valley San Diego Hotel
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
7.8/10 Good! (1,589 reviews)
"Overall, a nice property in a convenient and central part of town. Was a bit disappointed with the check-in experience, I requested a room with a balcony and paid a premium for this option. When I got to my room, my balcony "view" was of the parking lot and busy freeway! Not worth the $50 up charge. ..."

Reviewed on Feb 17, 2025

Handlery Hotel
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,560 reviews)
"I really liked the calmness."

Reviewed on Feb 21, 2025

Sheraton San Diego Resort
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9/10 Wonderful! (2,139 reviews)
Nice place to stay near the marina
"We enjoyed our stay. Room was clean, quiet, and comfortable. Grounds are very pretty and tropical. Was a little disappointed that fresh coffee wasn’t served in the lobby during the morning. Had to pay for coffee at the restaurant next door or use the tiny coffee maker in the room."

Reviewed on Feb 22, 2025

Humphreys Half Moon Inn
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (622 reviews)
"This is the most beautiful and amazing hotel!"

Reviewed on Feb 17, 2025

Lafayette Hotel & Club
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,144 reviews)
"The hotel is great! Gym, pool, rooms, restaurants and clean. Beds comfortable! Parking is only $15 per night. The service desk people are niceish but strangely not very helpful. You will have to call the front desk way more then you need too. Finding your room the first time is not easy because they ..."

Reviewed on Feb 21, 2025

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $94
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.