Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,470 reviews)
"This was a great property for location to the beach. A short 10 minute drive. There was also a shopping area just 5 minutes away with a ton of restaurants and a mall. The pool and hot tub were great, and pool was heated. The property was a little run down, but the staff did a great job keeping it ..."

Reviewed on Apr 13, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,668 reviews)
"Easy access to Dinning and Shopping within walking distance."

Reviewed on Apr 13, 2025

Wyndham San Diego Bayside
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,175 reviews)
"Outstanding service and amenities! Our stay here on our last day of our vacation was amazing. Will stay here again!"

Reviewed on Apr 12, 2025

San Diego Mission Bay Resort
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,304 reviews)
Close to SeaWorld & nice pool
"Hotel was nice but a few things were annoying like the car parking charge of $29 a night felt excessive. Food was average. No black out blinds and road and plane noise could be quite noisy at times. My kids loved the pool and our room was right next to it that also had its plus and minus points as ..."

Reviewed on Apr 12, 2025

The Dana on Mission Bay
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (2,131 reviews)
"Beautiful environment."

Reviewed on Apr 12, 2025

Paradise Point Resort & Spa
Hilton San Diego Mission Valley
Hilton San Diego Mission Valley
4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
7.8/10 Good! (1,594 reviews)
Good hotel but parking should be free
"Clean and comfortable modern rooms. Loved the spacious bathroom counters. It would be nice if parking was free."

Reviewed on Apr 13, 2025

Hilton San Diego Mission Valley
Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free parking, a beach locale, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (1,512 reviews)
"Beachfront, close to belmont amusement park. Great place for kids. Rollercoaster and lots of rides and games and arcades"

Reviewed on Apr 13, 2025

Bahia Resort Hotel
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9.2/10 Wonderful! (2,247 reviews)
"Overall a great 2 nights at the hotel. We’ve stayed before & really enjoyed it. Unfortunately we had construction going on above us & work started at 8am, that was the only downfall."

Reviewed on Apr 10, 2025

Humphreys Half Moon Inn
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (740 reviews)
"Beautiful"

Reviewed on Apr 12, 2025

Lafayette Hotel & Club
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
7.2/10 Good! (3,848 reviews)
"The property is perfectly located within minutes of all the big attractions, amazing food, and great beaches. The property was very quiet ( some guests you can't keep quiet so I don't knock the hotel for that). The room was massive giving our two year old plenty of room to run around in the room. ..."

Reviewed on Apr 9, 2025

Wyndham Garden San Diego Near SeaWorld
Best Western Seven Seas
Best Western Seven Seas
3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.6/10 Good! (2,698 reviews)
"Very clean in a nice area easily accessible"

Reviewed on Apr 12, 2025

Best Western Seven Seas
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,219 reviews)
"Great staff, clean rooms I.will stay again!"

Reviewed on Apr 12, 2025

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $114
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.