Hotels Near
Otay Mesa

Check Last Minute Otay Mesa Hotel Deals

Tonight May 19 - May 20Next weekend May 24 - May 26

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured Otay Mesa Hotels

Best Western Seven Seas
Best Western Seven Seas
3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 spa tubs. Our guests praise the pool and the helpful staff in ...
7.4/10 Good! (2,475 reviews)
Would definitely book again
"I showed up a tad bit early and reception said no rooms showed up as available in her computer, however, she took the extra step to call one of the housekeepers and they told her a room was available. I was able to check in early with no problem! That was very kind of front desk to do. The room was ..."

Reviewed on May 18, 2024

Best Western Seven Seas
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
7/10 Good! (2,638 reviews)
"It was clean and quiet! A little over priced for the area!"

Reviewed on May 17, 2024

Wyndham Garden San Diego Near SeaWorld
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the restaurant and the ...
8/10 Very Good! (5,903 reviews)
Close to so many activities
"I like the fact that the hotel is close to harbor and so many activities!"

Reviewed on May 16, 2024

Wyndham San Diego Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the breakfast and the pool in our ...
8.6/10 Excellent! (2,443 reviews)
Frequent SD vsitor
"It was nice to stay at the Dana where I can always know what I’m getting. A friendly check in process , easy parking and clean room. I visit often because my son and several of my girlfriends live in SD. Using the hotel.com app I was able to use my points and received a fantastic rate even on Mother’s ..."

Reviewed on May 16, 2024

The Dana on Mission Bay
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.4/10 Very Good! (1,819 reviews)
"Great property"

Reviewed on May 16, 2024

Paradise Point Resort & Spa
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (2,234 reviews)
"love the clean white linens!"

Reviewed on May 15, 2024

Sheraton San Diego Hotel and Marina
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,232 reviews)
"The staff were amazing, really nice and helpful!"

Reviewed on May 16, 2024

Manchester Grand Hyatt San Diego
Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA