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4 Star Hotels in St. Charles

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Featured 4 Star St. Charles Hotels

Hyatt Regency St. Louis at The Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from Ameristar Casino St. Charles
The price is $117 per night from Dec 30 to Dec 31
$117
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min drive from Ameristar Casino St. Charles
The price is $133 per night from Jan 24 to Jan 25
$133
includes taxes & fees
Jan 24 - Jan 25, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Renaissance St. Louis Airport Hotel
21C Museum Hotel St Louis
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $170 per night from Dec 30 to Dec 31
$170
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
21C Museum Hotel St Louis
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Moonrise Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from Ameristar Casino St. Charles
The price is $189 per night from Dec 30 to Dec 31
$189
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Moonrise Hotel
Ameristar Casino Resort and Spa
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 min walk from Ameristar Casino St. Charles
The price is $214 per night from Jan 2 to Jan 3
$214
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
Ameristar Casino Resort and Spa
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 35 min drive from Ameristar Casino St. Charles
The price is $117 per night from Jan 20 to Jan 21
$117
includes taxes & fees
Jan 20 - Jan 21, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
The Last Hotel
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $135 per night from Jan 3 to Jan 4
$135
includes taxes & fees
Jan 3 - Jan 4, 2025
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
The Last Hotel
River City Casino & Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from Ameristar Casino St. Charles
The price is $139 per night from Jan 2 to Jan 3
$139
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
River City Casino & Hotel
Live by Loews - St.Louis
4 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from Ameristar Casino St. Charles
The price is $189 per night from Jan 1 to Jan 2
$189
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Live by Loews - St.Louis
Le Méridien St. Louis Clayton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from Ameristar Casino St. Charles
The price is $187 per night from Dec 31 to Jan 1
$187
includes taxes & fees
Dec 31 - Jan 1, 2025
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Le Méridien St. Louis Clayton
St. Louis Union Station Hotel, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $171 per night from Jan 5 to Jan 6
$171
includes taxes & fees
Jan 5 - Jan 6, 2025
Book a stay at this historic hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 7 restaurants. Our guests praise the helpful staff and the clean rooms ...
St. Louis Union Station Hotel, Curio Collection by Hilton
Hilton Pennywell St. Louis at the Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from Ameristar Casino St. Charles
The price is $122 per night from Jan 4 to Jan 5
$122
includes taxes & fees
Jan 4 - Jan 5, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a fitness center, and valet parking (surcharge). Our guests praise the ...
Hilton Pennywell St. Louis at the Arch
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in St. Charles

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in St. Charles for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in St. Charles as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag St. Charles 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in St. Charles starting at $117 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded St. Charles 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.