Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

Days Inn by Wyndham San Diego Hotel Circle
Days Inn by Wyndham San Diego Hotel Circle
3 out of 5
543 Hotel Circle S, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
7.6/10 Good! (2,166 reviews)
"It was a quiet and comfortable hotel . Lots of restaurants and stores . Pool was nice . Bed was firm but nice ."

Reviewed on May 10, 2025

Days Inn by Wyndham San Diego Hotel Circle
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,210 reviews)
"I loved it ! Great place to stay"

Reviewed on May 8, 2025

San Diego Mission Bay Resort
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,373 reviews)
"Great property; loved the pools and the hot tubs; wonderful staff; wish they had 2 restaurants on site; loved the daily drink specials"

Reviewed on May 10, 2025

The Dana on Mission Bay
Loews Coronado Bay Resort
Loews Coronado Bay Resort
4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (1,003 reviews)
"Location"

Reviewed on May 2, 2025

Loews Coronado Bay Resort
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,718 reviews)
"The Bar was excellent the rooms ok"

Reviewed on May 13, 2025

Wyndham San Diego Bayside
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,238 reviews)
"Was not happy about the $15. Parking Fee. We were also put right next to the pool area, and the screaming and shouting went on all night long until 10pm. It was horrible !"

Reviewed on May 12, 2025

Kings Inn San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,469 reviews)
"Beautiful hotel friendly staff very helpful and fun time at pool"

Reviewed on May 12, 2025

Hyatt Regency Mission Bay Spa and Marina
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,749 reviews)
"Great location and food!"

Reviewed on May 13, 2025

Manchester Grand Hyatt San Diego
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (814 reviews)
"The room door lead to a beautiful sitting area that led to the gorgeous pool area! So convenient for me and my family. I loved it here!"

Reviewed on May 13, 2025

Lafayette Hotel & Club
Legacy Resort Hotel & Spa
Legacy Resort Hotel & Spa
4 out of 5
875 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
9/10 Wonderful! (2,892 reviews)
"Very clean and welcoming, location was perfect"

Reviewed on May 11, 2025

Legacy Resort Hotel & Spa
Hilton San Diego Mission Valley
Hilton San Diego Mission Valley
4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
7.8/10 Good! (1,643 reviews)
Thanks
"Thanks"

Reviewed on May 11, 2025

Hilton San Diego Mission Valley
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 5 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,637 reviews)
"The shower leaked into the sleeping area. This resulted in mold in the rug in the sleeping area"

Reviewed on May 13, 2025

Sheraton San Diego Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.