Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

Best Western Seven Seas
Best Western Seven Seas
3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 spa tubs. Our guests praise the pool and the helpful staff in our reviews. ...
7.4/10 Good! (2,431 reviews)
"Property was nice, clean, and accessible. The only thing that was difficult was the parking... it was hard to maneuver a van in the space close to the room."

Reviewed on Apr 14, 2024

Best Western Seven Seas
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (5,987 reviews)
"Surprised at the speed of the drain in the tub and in the bathroom sink, very very slow,"

Reviewed on Apr 14, 2024

Wyndham San Diego Bayside
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Diego. Enjoy free WiFi, onsite parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean ...
7/10 Good! (2,510 reviews)
"Homeless people around the property and hanging around the rooms , does not feel safe especially when we’re with family and babies"

Reviewed on Apr 14, 2024

Wyndham Garden San Diego Near SeaWorld
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this family-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 poolside bars. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (2,368 reviews)
"Right in the bay"

Reviewed on Apr 15, 2024

The Dana on Mission Bay
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
Stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,319 reviews)
"The room was lovely and we had a fantastic view of the bay. Only wish was that there would have been a place for a drink open later than 11:00."

Reviewed on Apr 14, 2024

Manchester Grand Hyatt San Diego
Legacy Resort Hotel & Spa
Legacy Resort Hotel & Spa
4 out of 5
875 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (2,757 reviews)
Awesome room&location and a great Hotels.com deal!
"I came across this hotel at the last minute looking for a local hotel to stay after a concert at Petco Park. The hotels surrounding the stadium were all either sold out or rates were hiked for the event. I found the Legacy on Hotels.com and was able to book three days prior for a great rate (other ..."

Reviewed on Apr 14, 2024

Legacy Resort Hotel & Spa
Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this beach resort in San Diego. Enjoy free parking, a marina, and a beach locale. Our guests praise the pool and the restaurant in our reviews. Popular ...
8.4/10 Very Good! (1,251 reviews)
"Everything about it was perfect and relaxing Will be back soon again"

Reviewed on Apr 12, 2024

Bahia Resort Hotel
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,868 reviews)
"Came here to celebrate my husband's birthday. We had such a an amazing,fun and relaxing time. Can't wait to come back!"

Reviewed on Apr 15, 2024

Paradise Point Resort & Spa
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the restaurant and the helpful staff in our reviews. ...
8.6/10 Excellent! (2,038 reviews)
"Great location. Very expensive. Had fun"

Reviewed on Apr 14, 2024

Hard Rock Hotel San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 2 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular ...
8.4/10 Very Good! (1,443 reviews)
"My family had a two day experience there and it was great, I will book this hotel again next time"

Reviewed on Apr 11, 2024

Hyatt Regency Mission Bay Spa and Marina
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this beach hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a beach locale. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,017 reviews)
"Was very pleased with hotel property and staff. Only issue is with the location, have to drive to get to mission beach or pacific beach, etc. Unless you're willing to walk several miles."

Reviewed on Apr 11, 2024

San Diego Mission Bay Resort
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4 out of 5
1 Park Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy 2 bars/lounges, a full-service spa, and breakfast. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,514 reviews)
"It’s nice that it’s next to shore…"

Reviewed on Apr 13, 2024

Hilton San Diego Bayfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $94
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.