Search for Cheap Deals onHistoric Hotels in Otay Mesa
Check Last Minute Otay Mesa Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Otay Mesa Historic Hotels
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
Top Points of Interests in Otay Mesa
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Petco Park
- Hotels near Port of San Diego
- Hotels near Balboa Park
- Hotels near Hotel Circle
- Hotels near Mission Beach
- Hotels near Marine Corps Recruit Depot
- Hotels near Naval Base San Diego
- Hotels near USS Midway Museum
- Hotels near Hotel del Coronado
- Hotels near Las Americas Premium Outlets
- Hotels near Coronado Beach
- Hotels near University of San Diego
- Hotels near B Street Cruise Ship Terminal
- Hotels near Seaport Village
- Hotels near San Diego State University
Cities near Otay Mesa
- San Diego Hotels (15.34 mi)
- Chula Vista Hotels (8.51 mi)
- Coronado Hotels (14.99 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Rosarito Hotels (14.31 mi)
- El Cajon Hotels (16.26 mi)
- Coronado Island Hotels (16.04 mi)
- National City Hotels (10.98 mi)
- Southern California Hotels (91.04 mi)
- La Mesa Hotels (14.67 mi)
- San Ysidro Hotels (4.08 mi)
- Imperial Beach Hotels (8.3 mi)
- Alpine Hotels (22.51 mi)
- Tecate Hotels (19.72 mi)
- Santee Hotels (19.26 mi)
- Spring Valley Hotels (12.88 mi)